Vol 19, No 4 (2016)


Acanthosis nigricans in patient with breast cancer and hepatocellular carcinoma: case report and review of the literature

Saribekyan E.K., Zubovskaya A.G.


Acanthosis nigricans (AN) is characterized by hyperpigmented, thickened skin plaques with a velvety texture. The histology of these lesions shows hyperkeratosis and dermal papillomatosis. According to the clinical data the key role in the development of acanthosis nigricans belongs to an excessive concentration of growth factors. Such condition is ofparticular interest because of its association with internal malignancies. Its malignant form is often associated with gastric adenocarcinoma (55-61%), though coexistence with a variety of other malignancies (ovarian cancer, endometrial carcinoma, bladder cancer, etc.) has been reported. Clinical case of patient with AN and coexisting breast cancer and hepatocellular carcinoma is presented. The severity of skin manifestations improved after chemotherapy, mastectomy and radiation therapy. However, skin hyperpigmentation relapsed after development of the hepatocellular carcinoma and the progression of the primary tumor. An underlying malignancy should be suspected in each case of AN.
Russian Journal of Skin and Venereal Diseases. 2016;19(4):196-199
pages 196-199 views

Microarray comparative analysis of melanoma microRNA depending on the tissue fixation method

Komina A.V., Palkina N.V., Aksenenko M.B., Ruksha T.G.


Cutaneous melanoma is the most aggressive form of skin cancer characterized by rapid progression, invasiveness and low survival rates. This explains the importance of optimization of early detection of this tumor. At the present time molecular and genetic methods of cancer investigation are broadly used. One of such methods is microarray that allows to analyze the expression of thousands genes in the single cell. However, this method makes high demands on the quality of samples and research procedure. Today the most common approach for tumor tissue preservation is formalin fixation followed paraffin embedding. This procedure is broadly used in clinical medicine but may affect the structure and availability of nucleic acids of the study sample. The present investigation was done to evaluate the effect of melanoma tissue fixation on the result of microRNA expression analysis by microarray. In this regard, we made comparative study of microRNA expression in melanoma samples fixed in formaldehyde and RNase inhibitor reagent based on ammonium sulfate solution. It has been shown that fixation by formalin as compared to ammonium salts based RNase inhibiting fixator alters the level of 454 microRNAs. Some miRNAs among them are playing an important role in the melanoma progression. Thus, molecular studies of skin tissues by microarray requires more thorough standardization of sample fixation methods or using of special RNA stabilizing solutions. The application of the formalin fixation method to preserve tissue for miRNA expression analysis requires further study.
Russian Journal of Skin and Venereal Diseases. 2016;19(4):200-205
pages 200-205 views

Erythema Infectiosum: clinical case

Pashinyan A.G., Runikhina N.K., Mokeeva E.Y.


Human Parvovirus B19 has been recognized as the causative agent of a wide range of diseases. The cellular receptorfor parvovirus B19 is P antigen located on the trophoblast cells, bone marrow, liver, kidney, synovium, etc. has been associated with many clinical situations, erythema infectiosum and erythroblastopenia crisis. In the absence of P-antigen, revealed no susceptibility to parvovirus infection. Infection in pregnant women under 20 weeks gestation can lead to miscarriage or non-immune hydrops, fetal death. 1-5% of women are susceptible to parvovirus infection during pregnancy. Viral infection may be responsible for aplastic anaemia in immuno-compromised patients. Diagnosis ofparvovirus infection B19 is based on the results of general blood analysis; biochemical analysis of blood; serological methods, PCR detection of IgM, immunoblot IgM/IgG. The most common clinicalform of parvovirus B19 infection in children is erythema infectiosum. It is also called “fifth disease”. Erythema infectiosum is characterized by a viral prodrome followed by the “slapped cheek’ facial rash and macula papular lace or mesh rash on the skin of the trunk and extensor surfaces.
Russian Journal of Skin and Venereal Diseases. 2016;19(4):206-209
pages 206-209 views

Prospects of correction of endotoxemia and metabolic syndrome comorbid with allergic dermatitis

Snarskaya E.S., Arsentiev N.S.


Endotoxin of Gram-negative bacteria of the digestive tract, which has a high degree of toxicity to humans, is considered today as a factor in inducing allergic development and formation of combinedforms of atopic dermatitis (AD), is capable of a more severe disease. Increasing the level of endotoxin leads to the development of endogenous intoxication syndrome (EIS) that accompanies the disease, providing a damaging effect on the tissue and determining the prognosis of AD. At SEI complex metabolic disorders is forming that leads not only to a decrease in the volume of organs of the immune system, increase the permeability of natural barriers, but also to a defect interaction of its individual effector units. Excretion of endogenous and exogenous stimuli from the body at allergic dermatosis prevents the formation of secondary immune deficiency and the further development of the pathological process of the skin, contributing to its stabilization and sustainable long-term remission. Application of detoxifying drug “Eubikor” and general aerocryotherapy at atopic dermatitis leads to more intense reduction of SCORAD, reduces the frequency of exacerbations and increase duration of remission. Method of aerocryotherapy was used to stimulate the mechanisms of activation of metabolism and regeneration of damaged tissues. Clinical experience of “Eubikor” and aerocryotherapy rate in patients with atopic dermatitis is presented.
Russian Journal of Skin and Venereal Diseases. 2016;19(4):210-216
pages 210-216 views

Stevens-Johnson syndrome

Olisova O.Y., Grabovskaya O.V., Teplyuk N.P., Lepekhova A.A., Ignatiev D.V., Ignatieva K.V.


The literature review of the epidemiology, etiology and pathogenesis, clinical presentation and diagnosis of the syndrome of Stevens-Johnson severe life-threatening disease characterized by extensive lesions of the skin and mucous membranes, fever and bone and muscle aches, often induced by medication is presented. A review on the methods of treatment and prevention of this disease is presented. The clinical case of patient with the syndrome of Stevens-Johnson is described. The successful treatment of Syndrome Stevens-Johnson with high-dose systemic glucocorticoids was performed.
Russian Journal of Skin and Venereal Diseases. 2016;19(4):216-220
pages 216-220 views

Assessment of dermatoheliosis with reflectance confocal microscopy

Snarskaya E.S., Tkachenko S.B., Kuznetsova E.V.


Dermatoheliosis increases the risk of developing malignant epithelial skin tumors and locates on aesthetically critical areas. Therefore there is a need for noninvasive objective technique capable of in vivo assessing the cumulative effect of UV-radiation, the severity ofphotoaging and the risk of epithelial skin cancer. In our study we aimed to determine the morphological changes occurring on photoaged skin and early signs of keratinocyte dysplasia by means of reflectance confocal microscopy (RCM). Material and method. The samples of facial skin of 40 volunteers from distinct groups, determined by Glogau scale (grades I-IV), have been examined with RCM. Results. The presence of irregular honeycomb pattern is increasing with progressing of dermatoheliosis. Mottled pigmentation and polycyclic papillary contours were determined in grade II-IV Glogau individuals, in the number of cases there were not demonstrated any pathological skin changes in analyzing area. Dermal structures are significantly transforming: reticulated collagen fibers are replacing with coarse collagen structures, huddled collagen and curled bright structures. RCM is capable of identifying early signs of sun damage and keratinocyte dysplasia in skin in the absence of any clinically visible symptoms.
Russian Journal of Skin and Venereal Diseases. 2016;19(4):220-226
pages 220-226 views

Exceptional case of disseminated necrobiosis lipoidica similar to a sarcoidosis form at the child affected by diabetes type I

Bazaev V.T., Tseboeva M.B., Tsarueva M.S.


The article describes the infrequent disseminated necrobiosis lipoidica similar to a sarcoidosis form which developed at the five-year-old child affected by type 1 diabetes mellitus. The short review concerns the questions of an etiology, pathogenesis, clinical forms, diagnostics and the modern methods of treatment of the described pathology. In the review 26 sources of literature are used. The case is of interest to dermatovenereologists, endocrinologists, pediatricians.
Russian Journal of Skin and Venereal Diseases. 2016;19(4):227-230
pages 227-230 views

Grover's disease

Karaseva Y.V., Smykova A.N., Voloshin V.V.


A review of the etiology, pathogenesis, clinical manifestations and histological characteristics of a rare dermatosis - Grover’s disease is presented. The difficulty of histopathology differential diagnosis of this disease with Darier’s disease andfamilial benign pemphigus Guzhero-Hailey-Hailey is described. The clinical case of Grover’s disease in 87 year old man is presented.
Russian Journal of Skin and Venereal Diseases. 2016;19(4):231-233
pages 231-233 views

Hidradenitis suppurativa: treatment (part 3)

Masyukova S.A., Mordovtseva V.V., Zemlyakova S.S., Gubanova E.I., Ilina I.V., Sanakoeva E.G., Alieva Z.A., Grebenyuk D.V.


Local and systemic methods are used for the treatment of hidradenitis suppurativa, the choice of which depends on the stage of the disease. For local treatment adapalene, clindamycin, azelaic acid, silver preparations in combination with surgical excision, laser therapy and cryo are used. For systemic treatment antibiotics (clindamycin, rifampicin, erythromycin, amoxicillin with clavulanic acid, minocycline), prednisolone, cytostatics (methotrexate, azathioprine, cyclosporine), retinoids, biologicals (etanercept, efalizumab, adalimumab, infliximab), a non-steroidal anti-inflammatory drugs are used. The aim of therapy is to get anti-inflammatory effect, the removal offollicular occlusion and pain, correction of immune and hormonal status, stimulation of healing of skin defects, improving the quality of life of patients.
Russian Journal of Skin and Venereal Diseases. 2016;19(4):233-237
pages 233-237 views

Differential diagnosis between acrokeratosis verruciformis of Hopf and hypertrophic lichen planus

Molochkov V.A., Molochkova Y.V., Bobrov M.A.


The article is devoted to the differential diagnosis of hypertrophic form of lichen planus (CPL) with acrokeratosis verruciformis of Hopf (AVH). It is very rare hyperkeratotic genodermatosis usually inherited in an autosomal dominant manner. Due to the marked clinical similarity of these two dermatoses crucial for the correct diagnosis is histological study of the lesion with the identification of histological feature unique for AVH - papillomatosis as a “church steeples”. Two clinical cases diagnosed last year in the department of dermatology and dermatooncology in Moscow regional research and clinical institute are described in the article. The effectiveness of the treatment AVH with acitretin was described.
Russian Journal of Skin and Venereal Diseases. 2016;19(4):238-241
pages 238-241 views

Vitiligo: etiology, pathogenesis and therapy

Kruglova L.S.


Vitiligo is an autoimmune disease. The prevalence of the disease is 0.5% of the population. The main etiological factor is genetic defect of melanogenesis enzymatic system. The article is a review. The current data on the pathogenesis, classification and treatment of vitiligo are presented. Existing therapies mainly have moderate efficacy. The principal methods of treatment are ultraviolet therapy, laser therapy, topical corticosteroids and calcineurin inhibitors.
Russian Journal of Skin and Venereal Diseases. 2016;19(4):241-244
pages 241-244 views

High-frequency therapy of primary axillary hyperhidrosis

Pinson I.Y., Olisova O.Y., Verkhoglyad I.V.


The article is devoted to a new method of treatment ofprimary axillary hyperhidrosis UHF technology. Anatomy, topography and function of the sweat glands, as well as the mechanism of action of ultrahigh-frequency therapy electromagnetic field frequency from 30 to 300 MHz (wavelength of 10 m to 1 m) in continuous or pulsed mode are described. The aim of the study was to investigate the efficacy and safety of UHF-therapy apparatus SweatX at axillary hyperhidrosis. Inclusion criteria was hyperhidrosis corresponding to the scale of gravity HDSS (Hyperhidrosis Disease Severity Scale) 3 rd and 4 th degree: before treatment in 8 patients HDSS level was equal to 4, in 12 patients - 3. Each patient received a series 4 treatments with an interval of 1 week. Underarm pictures with iodine-starch test subjects was performed at baseline and after 1, 3 and 6 months after the last treatment. Each procedure SweatX exposure consisted of two stages. The total processing time of each axilla was 8-10 minutes (about 20 minutes on both armpits). In the study, as well as between the procedures and follow-up visits were observed no undesirable side effects. After 6 months of follow up indicators HDSS sweating on a scale from 11 (55%) patients dropped to 2, and 9 (45%) patients -1. Thus, on the basis of SweatX use of UHF technology provides a safe, effective and lasting solution to the problems encountered in patients with primary hyperhidrosis underarm.
Russian Journal of Skin and Venereal Diseases. 2016;19(4):245-248
pages 245-248 views

Syphilitic a multiple giant aortic aneurysm

Novoselov V.S., Kvizhinadze G.N., Tumanova E.L., Belousov S.R., Smirnova L.M.


In recent years there has been growth in the number of clinical manifestations of late forms of syphilis with damage to the cardiovascular system. This fact makes it necessary to conduct a careful examination of patients with aortic aneurysms and similar lesions of the cardiovascular system. The article gives an overview of modern literature of giant syphilitic aortic aneurysms. The clinical case of multiple syphilitic aneurysm with compression of nearby organs, revealed in vivo is described. The data of instrumental, histopathology, immunohistochemical methods of investigation and the operation are presented.
Russian Journal of Skin and Venereal Diseases. 2016;19(4):249-253
pages 249-253 views

Podvisotskaya O.N. the first academician dermatologist since the moment of establishment of the AMS USSR

Stochik A.A., Kryazheva S.S.


Olga Nikolaevna Podvisotskaya (1884-1958) made her way up from the laboratory assistant at the Clinic of Dermal and Venereal Diseases at the St. Petersburg Women’s Medical Institute to the first dermatologist academician at the Academy of Medical Sciences of the USSR. She is one of the leaders of the domestic dermatology of the mid 20th century and the creator of a new school of dermatology, based on pathophysiological researches. O.N. Podvisotskaya is the author of fascinating researches on blastomycosis, chromoblastomycosis, epidermophytia (acute trichophytia of Podvisotskaya), onychomycosis, tuberculosis. She is known as the founder of the Leningrad Lupus Sanatorium. At this time the process of formation of the Academy of Medical Sciences as a standalone structure, designed to put together the practical and theoretical sciences in the country has been evolving. One of the complex phases in this process was the foundation of All Union Institute of Experimental Medicine (AUIEM) and its further reorganisational changes. O.N. Podvisotskaya was taking most active part in the activities of the AUIEM and later - at the AMS after becoming the academician, since the moment of foundation of the Academy of Medical Sciences in 1944.
Russian Journal of Skin and Venereal Diseases. 2016;19(4):253-254
pages 253-254 views

XVI Russian national congress of dermatovenerologists and cosmetologists

Makhneva N.V.
Russian Journal of Skin and Venereal Diseases. 2016;19(4):255-255
pages 255-255 views

From the collection of the dermatologist Tsareva E.D. A variety of severe hair loss

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Russian Journal of Skin and Venereal Diseases. 2016;19(4):256-256
pages 256-256 views

Multiple nodules on the skin of the back

Kuklin I.A., Kokhan M.M., Safonova G.D., Sorokina N.D.
Russian Journal of Skin and Venereal Diseases. 2016;19(4):257-258
pages 257-258 views

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