Vol 16, No 4 (2013)

The expression of CD45 (hemopoietic cell marker) in cutaneous melanoma cells was studied in 96 patients (40 men and 56 women). The expression was detected in 17.5% patients, mainly with Clark’s tumor invasion levels IV and V and Breslow’s thickness of the tumor 3.7±1.09 mm. Data on the relationship between this marker’s expression and clinical morphological characteristics of the disease are presented. The differential diagnosis of cutaneous melanoma is discussed.

Two cases of Lever’s paraneoplastic bullous pemphigoid in patients with ovarian cancer and left mammary carcinoma stage IIa are presented. Combined treatment (antitumor chemotherapy and diprospane) resulted to clinical remission in one patient.

A clinical case with a rare vascular disease of skin is presented: unilateral nevoid progressive telangiectasia in a female patient aged 30. The dermatoscopic picture of skin changes was characterized by extension of the capillary network without signs of follicular hyperkeratosis and atrophy, which allowed ruling out discoid lupus erythematosis, previously suspected in the patient. A brief review of the relevant publications is presented and problems in the differential diagnosis of this disease are discussed.

Modern data on the etiology and mechanisms of localized scleroderma development are presented. The therapeutic methods used in different clinical forms and stages of the pathological process localized scleroderma are described in detail.