Vol 16, No 1 (2013)

Articles

15-y yubiley nashego zhurnala

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Russian Journal of Skin and Venereal Diseases. 2013;16(1):4-5
pages 4-5 views

TUBEROUS SCLEROSIS

Vazhbin L.B., Belova N.I., Ltezvinskaya E.M., Stribuk P.V.

Abstract

A case with a rare hereditary disease — tuberous sclerosis - is described. In addition to skin involvement, the disease is characterized by congenital epidermal dysplasia involvement of the nervous system, organ of vision, cardiovascular system, kidneys, and other organs and systems. The authors emphasize the importance of complete examinations of these patients with consideration for the probable visceral involvement.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):6-9
pages 6-9 views

EXPRESSION OF T-CADHERIN IN KERATINOCYTES AND VESSELS OF EPITHELIAL TUMORS OF THE SKIN

Rubina K.A., Sysoeva V.Y., Semina E.V., Yurlova E.I., Molochkov V.A., Khlebnikova A.N., Sedova T.G.

Abstract

The expression of T-cadherin was studied in normal skin, in psoriasis, epithelial benign and malignant tumors of the skin. In normal skin T-cadherin was expressed by epidermal basal cells. Basal expression was also detected in psoriasis, actinic keratosis, keratoacanthoma, and surface basiloma. The expression of T-cadherin was significantly lower in malignant tumor cells (infiltrative basiloma, metatypical and squamous cell cancer). Normal skin vascular endotheliocytes and benign tumor cells expressed von Willebrand ’s factor (vWF) and T-cadherin. Loss of expression of the classical markers of endothelial cells (vWF), expression of -actin in vessel-like structures, and heterogeneity of T-cadherin expression in tumor vessels correlated with histological signs and invasive phenotypes of more aggressive tumors, such as metatypical cancer, invasive basiloma, and squamous cell carcinoma.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):9-15
pages 9-15 views

TRANSLATION CELLULAR IMMUNOTHERAPY IN THE TREATMENT OF IDIOPATHIC AND IMMUNOSUPPRESSIVE KAPOSI’S SARCOMA

Kartashova M.G., Kildyushevsky A.V., Molochkov A.V.

Abstract

Translation cellular immunotherapy was carried out in 20 patients with Kaposi ’s sarcoma, The immune status of patients was evaluated before and after therapy. The clinical picture and periods of remission indicated the efficiency of therapy.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):15-17
pages 15-17 views

ON THE DIAGNOSIS AND TREATMENT OF PEMPHIGUS SEBORRHEICUS

Zavadsky V.N.

Abstract

Errors in the early diagnosis of pemphigus seborrheicus at are described. Delayed beginning of adequate treatment aggravates the subsequent disease course and can promote transformation of pemphigus seborrheicus into pemphigus vulgaris. Dexamethasone is recommended as a total systems corticosteroid for the treatment of pemphigus seborrheicus.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):18-21
pages 18-21 views

X-LINKED ICHTHYOSIS

Tereshchenko V.N., Karpylaeva N.E., Ryabkova M.V., Shevelyova O.Y.

Abstract

A rare clinical case, interesting for a practicing dermatologist. is described: X-linked ichthyosis.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):21-23
pages 21-23 views

INTRAFOCAL INTERFERON THERAPY FOR RELAPSING WARTS

Bagramova G.E., Sedova T.G., Khlebnikova A.N.

Abstract

Warts are benign formations of the skin, caused by human papillomaviruses. The efficiency of various treatments are discussed. Experience gained with intrafocal interferon therapy of relapsing warts is presented. This treatment is recommended as a method of choice for relapsing warts of the palms and soles, multiple vulgar warts, particularly located by the nails.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):23-26
pages 23-26 views

EXPRESSION OF MATRIX METALLOPROTEASES IN PSORIASIS AND ATHEROSCLEROSIS

Sautin M.E., Soboleva A.G., Zolotarenko A.D., Piruzyan E.S., Korsunskaya I.M., Orekhov P.Y., Chupin A.V., Bruskin S.A., Sobolev V.V.

Abstract

Psoriatic and atherosclerotic plaques were analyzed by the real time polymerase chain reaction. The expression of matrix metalloprotease genes (MMP-2 and MMP-9) was changed in psoriatic skin and in atherosclerotic vessels in comparison with intact specimens. Individual analysis for each patient showed that the level of MMP-2 gene expression in psoriatic skin was lower in comparison with the control in the majority of patients, while its level in atherosclerotic plaques was higher than normally. The probable key role of MMP-9 gene in the pathogenesis of psoriasis and atherosclerosis is hypothesized.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):27-30
pages 27-30 views

ANTICYTOKINE THERAPY FOR SEVERE PSORIASIS FORMS

Tarasenko G.N., Belyakin S.A., Ryzhman N.N., Kuzmina Y.V.

Abstract

Anticytokine therapy for severe psoriasis forms was carried out in an inpatient setting. Infliximab and ustekinumad were used in 8 and 2 patients, respectively. One patient developed an anaphylactic reaction in response to infliximab. Ustekinumab opens new vistas in therapy for severe psoriasis forms and is a first-line drug in anticytokine therapy, including cases with infliximab intolerance or inefficiency.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):30-33
pages 30-33 views

COMBINED THERAPY FOR SEVERE PSORIASIS FORMS

Kruglova L.S., Sharapova E.N., Babushkin A.M., Babushkin A.M.

Abstract

Low-dose cytostatic in combination with UVB 311 nm phototherapy was used for the treatment of patients with severe forms of psoriasis vulgaris. Combined drug and physiotherapy proved to be highly effective and safe.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):34-36
pages 34-36 views

CHANGES IN THE LEVELS OF MOLECULES MEDIATING LYMPHOCYTE MIGRATION TO THE SKIN IN PSORIASIS PATIENTS

Belonogov R.N., Ruksha T.G.

Abstract

The mechanisms of lymphocyte migration into the skin in psoriasis were studied in 22 patients. The study was carried out on biopsy specimens from patients with disease progress and regression stages. The sections were stained by immunohistochemical methods with monoclonal antibodies to CD45, CD99, CD162, and matrix metalloprotease-9. The derma was profusely infiltrated by lymphocytes expressing these markers during the progressive stage of psoriasis. Positively stained cells were found by the vessels and as groups of cells and individual cells in the papillary and reticular layers and near the epidermis. The number of positively stained cells reduced during the disease regression.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):37-39
pages 37-39 views

GENE METHYLATION IN CD3+ CELLS IN PSORIASIS

Sobolev V.V., Denisova E.V., Soboleva A.G., Korsunskaya I.M., Chekalin E.V., Zolotarenko A.D., Bruskin S.A.

Abstract

Gene methylation level in CD3+ cells of psoriasis patients in comparison with that in normal subjects was analyzed using Illumina microchips. Differentially methylated locuses were detected in CD3+ cells of psoriasis patients and normal subjects. FRK, JAK1, AKAP7, DYRK1A, PRKCA, RPS6KA2 kinase genes were detected in the most methylated locuses in CD3+ cells of psoriasis patients. The clear-cut separation of the samples into two groups suggested that the level of the studied genes methylation in CD3+ cells can serve for predicting liability to psoriasis and presumably for diagnosis of its early stages.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):40-43
pages 40-43 views

EXFOLIAC THERAPEUTIC CARE IN COMBINED THERAPY FOR ACNE VULGARIS IN ADOLESCENTS

Snarskaya E.S., Kuznetsova E.V.

Abstract

Care of the skin with acne vulgaris in adolescent age is described. The mechanism of action of Exfoliac topical means is described in detail and algorithm of care of the skin in patients with acne vulgaris and problematic fatty skin is suggested.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):44-48
pages 44-48 views

COMPARATIVE ANALYSIS OF METHODS FOR TREATMENT OF ANDROGENIC ALOPECIA BY A COMBINATION OF ZINC HYALURONATE AND PHYSICAL FACTORS

Korolkova T.N., Kharitonova E.E., Bezuglyi A.P., Belkov P.A.

Abstract

The effects of zinc hyaluronate electroporation (ZHE) and ZHE in combination with pulsed photostimulatory therapy on hair growth were studied. Hair growth was evaluated in androgen-dependent zones over the course of treatment (1 and 4 months after it). In group 1 (n=54) ZHE was carried out, in group 2 (n=37) wide-band pulsed photostimulatory therapy was combined with ZHE gel electropolation. Trichological examinations of patients included evaluation of morphometric values: hair compactness, percentage of hairs in the anagen and telogen phases, mean diameter of all hairs in the examined zone, and the percentage of velus and terminal (thin, medium, thick) hairs. Zink hyaluronate administered by electroporation caused anagen hair growth, stimulated the compactness and thickness of hairs in patients with androgenic alopecia. Addition of wide-band pulsed phototherapy improved significantly the results of treatment. Combination of ZHE and wide-band pulsed photostimulatory therapy can be used in the treatment of patients with androgenic alopecia.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):49-52
pages 49-52 views

MORBIGAN’S DISEASE

Pisklakova T.P., Ermak E.M., Lepikhina E.M.

Abstract

Morbigan ’s disease is a rare chronic disease with a progressive course, manifesting by edema of the middle third of the face and stubborn erythema. A 20-year-old patient suffering from the disease is described. The diagnosis was confirmed by ultrasonic examination of the skin, which detected thickening of the subcutaneous fat, dilatation of the lymph vessels, and moderate arterial hypervascularization. Roaccutane therapy in a course dose of 120 mg/kg led to clinical cure.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):52-54
pages 52-54 views

POTENTIALITIES OF ESTHETIC CORRECTION OF THE FACE BY BOTULOTOXIN A IN COMPLEX WITH HEMAGGLUTININ

Plotnikova E.V., Elkin V.D., Demchuk N.D., Mironov A.N.

Abstract

Comparative clinical trials of a Russian botulotoxin A (relatox and botox) for correction of the mimic muscles and blepharospasm were carried out on 120 volunteers (94 with mimic wrinkles and 26 with blepharospasm). The safety and therapeutic efficiency of the drugs were compared. Both drugs exhibited comparable high efficiency and safety and low reactogenic activity. The effect of relatox was somewhat more pronounced and its relaxing effect more lasting than that of botox.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):54-57
pages 54-57 views

BULLOUS DACTYLITIS IN A PATIENT WITH LEPROSY

Degtyarev O.V., Bezrukavnikova O.A., Korneyeva M.A., Ibadulaev Z.Y.

Abstract

A clinical case with bullous dactylitis is described and relevant publications are reviewed
Russian Journal of Skin and Venereal Diseases. 2013;16(1):58-59
pages 58-59 views

MODERN DIAGNOSIS OF GONOCOCCAL INFECTION AND INCIDENCE OF GONORRHEA IN THE KRASNOYARSK REGION

Anisimova E.N., Vinnik Y.Y., Prokhorenkov V.I., Katsyna G.I.

Abstract

The incidence of gonococcal infection in the Krasnoyarsk region is discussed. A total of 1642 patients with gonorrhea were recorded over 2011. The incidence was 56.7 per 100 000 in the adult population and 1.2 per 100 000 in adolescents. The disease was the most incident in subjects aged 20-29 years. A comparative analysis of methods for laboratory diagnosis of gonococcal infection, used at the Krasnoyarsk Territorial Center for Skin and Sexually Transmitted Diseases, was carried out.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):59-61
pages 59-61 views

EVALUATION OF PATHOGENETIC FACTORS OF CHRONIC PROSTATITIS DEVELOPMENT

Vnnik Y.Y., Prokhorenkov V.I.

Abstract

The main theories of chronic prostatitis development are discussed. Each factor is characterized in brief. Sexually transmitted infections play the key role. Detection of microorganisms in prostatic tissue and secretions in numerous studies supports the infectious theory. However, the pathological process in the organ is maintained for a long time under certain conditions: special anatomical structure of the prostate, congestion in the pelvic vessels and prostatic lobules, hormonal shifts in the males, immune and autonomic disorders.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):61-65
pages 61-65 views

OPTIMIZATION OF ALGORITHM OF DIAGNOSIS AND TREATMENT OF CHRONIC RELAPSING CERVICITIS

Molochkov A.V., Konstantinova Z.E., Bagramova G.E., Murakov S.V., Veredchenko A.V., Obraztsov I.G., Prozorov A.S., Popkov S.A.

Abstract

A total of 138 young nulliparous women planning pregnancy were examined. Analysis of their case histories showed frequent relapses of chlamydial and mycoplasmic infections of the urogenital tract. Such a colposcopic sign as “opacity” of the contents of closed glands of the cervix uteri (Nabote ’s cysts) indicated infection of the gland. Chlamydial and mycoplasmic infections could persist asymptomatically for a long time in Nabote ’s cysts. An approach to choice of diagnostic and therapeutic methods has been developed.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):65-67
pages 65-67 views

UVAZhAEMYE AVTORY!

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Russian Journal of Skin and Venereal Diseases. 2013;16(1):68-68
pages 68-68 views

THE PROBLEM OF FLAGELLANTS

Monakhov S.A.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):69-69
pages 69-69 views

ANNULAR ELEMENTS ON THE SKIN OF THE TRUNK AND LIMBS

Snarskaya E.S.
Russian Journal of Skin and Venereal Diseases. 2013;16(1):69-70
pages 69-70 views

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