Vol 16, No 1 (2013)

A case with a rare hereditary disease — tuberous sclerosis - is described. In addition to skin involvement, the disease is characterized by congenital epidermal dysplasia involvement of the nervous system, organ of vision, cardiovascular system, kidneys, and other organs and systems. The authors emphasize the importance of complete examinations of these patients with consideration for the probable visceral involvement.

Translation cellular immunotherapy was carried out in 20 patients with Kaposi ’s sarcoma, The immune status of patients was evaluated before and after therapy. The clinical picture and periods of remission indicated the efficiency of therapy.

A rare clinical case, interesting for a practicing dermatologist. is described: X-linked ichthyosis.

Psoriatic and atherosclerotic plaques were analyzed by the real time polymerase chain reaction. The expression of matrix metalloprotease genes (MMP-2 and MMP-9) was changed in psoriatic skin and in atherosclerotic vessels in comparison with intact specimens. Individual analysis for each patient showed that the level of MMP-2 gene expression in psoriatic skin was lower in comparison with the control in the majority of patients, while its level in atherosclerotic plaques was higher than normally. The probable key role of MMP-9 gene in the pathogenesis of psoriasis and atherosclerosis is hypothesized.

Low-dose cytostatic in combination with UVB 311 nm phototherapy was used for the treatment of patients with severe forms of psoriasis vulgaris. Combined drug and physiotherapy proved to be highly effective and safe.

Gene methylation level in CD3+ cells of psoriasis patients in comparison with that in normal subjects was analyzed using Illumina microchips. Differentially methylated locuses were detected in CD3+ cells of psoriasis patients and normal subjects. FRK, JAK1, AKAP7, DYRK1A, PRKCA, RPS6KA2 kinase genes were detected in the most methylated locuses in CD3+ cells of psoriasis patients. The clear-cut separation of the samples into two groups suggested that the level of the studied genes methylation in CD3+ cells can serve for predicting liability to psoriasis and presumably for diagnosis of its early stages.

The effects of zinc hyaluronate electroporation (ZHE) and ZHE in combination with pulsed photostimulatory therapy on hair growth were studied. Hair growth was evaluated in androgen-dependent zones over the course of treatment (1 and 4 months after it). In group 1 (n=54) ZHE was carried out, in group 2 (n=37) wide-band pulsed photostimulatory therapy was combined with ZHE gel electropolation. Trichological examinations of patients included evaluation of morphometric values: hair compactness, percentage of hairs in the anagen and telogen phases, mean diameter of all hairs in the examined zone, and the percentage of velus and terminal (thin, medium, thick) hairs. Zink hyaluronate administered by electroporation caused anagen hair growth, stimulated the compactness and thickness of hairs in patients with androgenic alopecia. Addition of wide-band pulsed phototherapy improved significantly the results of treatment. Combination of ZHE and wide-band pulsed photostimulatory therapy can be used in the treatment of patients with androgenic alopecia.

Comparative clinical trials of a Russian botulotoxin A (relatox and botox) for correction of the mimic muscles and blepharospasm were carried out on 120 volunteers (94 with mimic wrinkles and 26 with blepharospasm). The safety and therapeutic efficiency of the drugs were compared. Both drugs exhibited comparable high efficiency and safety and low reactogenic activity. The effect of relatox was somewhat more pronounced and its relaxing effect more lasting than that of botox.

The incidence of gonococcal infection in the Krasnoyarsk region is discussed. A total of 1642 patients with gonorrhea were recorded over 2011. The incidence was 56.7 per 100 000 in the adult population and 1.2 per 100 000 in adolescents. The disease was the most incident in subjects aged 20-29 years. A comparative analysis of methods for laboratory diagnosis of gonococcal infection, used at the Krasnoyarsk Territorial Center for Skin and Sexually Transmitted Diseases, was carried out.

A total of 138 young nulliparous women planning pregnancy were examined. Analysis of their case histories showed frequent relapses of chlamydial and mycoplasmic infections of the urogenital tract. Such a colposcopic sign as “opacity” of the contents of closed glands of the cervix uteri (Nabote ’s cysts) indicated infection of the gland. Chlamydial and mycoplasmic infections could persist asymptomatically for a long time in Nabote ’s cysts. An approach to choice of diagnostic and therapeutic methods has been developed.