Psoriatic and atherosclerotic plaques were analyzed by the real time polymerase chain reaction. The expression of matrix metalloprotease genes (MMP-2 and MMP-9) was changed in psoriatic skin and in atherosclerotic vessels in comparison with intact specimens. Individual analysis for each patient showed that the level of MMP-2 gene expression in psoriatic skin was lower in comparison with the control in the majority of patients, while its level in atherosclerotic plaques was higher than normally. The probable key role of MMP-9 gene in the pathogenesis of psoriasis and atherosclerosis is hypothesized.

Full Text

Экспрессия матриксных металлопротеаз при псориазе и атеросклерозе


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