Russian Journal of Skin and Venereal Diseases

Peer-review bimonthly medical journal.

Editor-in-chief

Journal founders

  • Izdatelstvo "Meditsyna"
  • Eco-Vector Publishing Group

Publisher

About

The journal covers issues in dermatology, venereology, and dermato-oncology, publishing different typologies of contributions. Among the topics are skin infections of pyococcal origin, mycoses, dermatozoonoses, bullous dermatoses, and cosmetic dermatology.

The journal reviews new textbooks and manuals on dermatology and venereology, discusses new tests and emerging clinical problems, etc. The journal is aimed at practitioners specializing in dermatology, venereology, cosmetology, urology, gynecology, pediatrics and other branches of medicine.

Types of accepted articles

  • reviews
  • systematic reviews and metaanalyses
  • original research
  • clinical case reports and series
  • letters to the editor
  • short communications
  • clinial practice guidelines

 

Publications

  • in English and Russian
  • bimonthly, 6 issues per year
  • continuously in Online First
  • with NO Article Processing Charges (APC)
  • distribution in hybrid mode - by subscription and/or Open Access
    (OA articles with the Creative Commons Attribution 4.0 International License (CC BY-NC-ND 4.0))

Indexation

  • Russian Science Citation Index (Web of Sciences)
  • Russian Science Electronic Library (eLibrary.ru)
  • Google Scholar
  • Ulrich's Periodicals directory
  • WorldCat
  • Crossref

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Current Issue

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Vol 25, No 2 (2022)

Cover Page

Full Issue

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DERMATO-ONCOLOGY

Reed’s syndrome: a combination of a renal cyst with leiomyoma of the skin and uterus (clinical observation)
Grekova Y.N., Zilberberg N.V., Toropova N.P., Kuznetsova E.I.
Abstract

Multiple cutaneous and uterine leiomyomatosis (MCUL), also known as Reed’s syndrome, is a rare genodermatosis, with an autosomal dominant pattern of inheritance. It results from a germline heterozygous mutation of fumarate hydratase gene, that is classified as a tumor suppressor gene. Hereditary leiomyomatosis and renal cell cancer is characterized by the association of multiple cutaneous and uterine leiomyomatosis with renal cell carcinoma. The diagnosis of multiple leiomyomas is based on the identification of morphological characteristic rashes (small, oval, red-brown or flesh-colored nodules located around the hair follicles, often painful) and is confirmed by the method of pathomorphological examination. Treatment of leiomyomas depends on their number, size, area of skin lesion and severity of subjective symptoms. With single rashes, surgical excision of the largest and most painful elements is possible, with severe pain syndrome ― calcium channel blockers, alpha-blockers and gabapentin. Cryotherapy, diathermocoagulation, and laser ablation with a carbon dioxide laser are used to destroy the nodes.

The presence of cutaneous leiomyomas in patients dictates the need for careful collection of anamnesis, including family and obstetric-gynecological, conducting a full-fledged clinical, laboratory and instrumental examination and consulting by related specialists. Annual screening for early detection and therapy of renal cell carcinoma is also mandatory.

Due to the existing probability of the hereditary nature of Reed’s syndrome, a thorough examination of the patient’s relatives is necessary.

We report a case of a 58-year-old woman with Reed’s syndrome: multiple cutaneous leiomyomas, uterine leiomyoma and renal cysts.

Russian Journal of Skin and Venereal Diseases. 2022;25(2):97-104
pages 97-104 views

DERMATOLOGY

On the new classification of dermatophytes
Pchelin I.M., Sergeev A.Y.
Abstract

According to the recent changes in the classification of the family Arthrodermataceae, it may already include 9 genera and 79 species. Dermatophytes associated with human and animal infections belong to the genera Trichophyton, Microsporum and Epidermophyton, whereas Arthroderma, Ctenomyces, Guarromyces, Lophophyton, Nannizzia and Paraphyton are mainly represented by geophilic species. Since morphological and physiological traits in fungi cannot provide reliable basis for classification, the modern system of dermatophytes was built on the basis of phylogenetic analysis of nucleotide sequences. The new dermatophyte classification employs the principle of “one fungus, one name”, according to which genetically similar perfect and imperfect forms belong to the same species.

At the current state of genosystematics, the taxonomic identification of dermatophytes in most cases requires the use of molecular methods, in particular, DNA sequencing of the ITS region.

In this review, we briefly outline the history of dermatophyte classification, summarize generic and species composition of the family and provide data on their ecology, accession numbers for reference sequences of ITS region, and references to major taxonomic publications.

Russian Journal of Skin and Venereal Diseases. 2022;25(2):105-118
pages 105-118 views
Features of the quality of life in patients with vitiligo
Lecaillon M., Lomonosov K.M.
Abstract

BACKGROUND: Vitiligo is an acquired skin disease whose etiology is still unknown. It is observed in 0.5–1% of the world population. Medical and social significance is due to the impact on the psychological state of the patient and the quality of his life.

AIMS: Analysis of the quality of life index in patients suffering from vitiligo.

MATERIALS AND METHODS: The results of questionnaires filled out by 150 patients (95 women and 55 men) suffering from vitiligo were studied in the work. The average age of the subjects was 34.56±1.73 years. A survey was conducted among the subjects: patients were asked questions from a questionnaire specially developed by us. The work also used the Dermatological Life Quality Index (DIQI). The questionnaire was filled in by all patients independently at the initial examination. The results were processed using Microsoft Excel from the Microsoft Office software package and the Statistica software package for statistical analysis.

RESULTS: The data obtained indicate that in all responses to the questions, the largest number of statements were classified as “strongly/very strongly”. This fact indicates a significant impact of this pathology on the quality of life of the subjects. The DLQI results also confirmed that the presence of vitiligo limits a person’s quality of life to the maximum (in 41.3% of cases) and has a large negative impact (in 53.3% of cases).

CONCLUSION: Performing further research on the study of quality of life in patients suffering from vitiligo is one of the promising areas for developing a personalized approach to managing this group of patients.

Russian Journal of Skin and Venereal Diseases. 2022;25(2):119-125
pages 119-125 views
Clinical and epidemiological features of psoriasis in the Republic of Uzbekistan
Olisova O.Y., Melikova N.I., Tashkenbaeva U.A., Torchinskiy N.V.
Abstract

BACKGROUND: Psoriasis is one of the most common dermatoses. The disease has a negative impact on every aspect of the patient’s life ― social, physical and psychological. Psoriasis is accompanied by a marked deterioration in the quality of life of patients, which often leads to their social maladaptation.

AIMS: This study is aimed at assessing the nature of epidemiological and clinical manifestations of psoriasis in the Republic of Uzbekistan.

MATERIALS AND METHODS: The data of the population register of psoriatic diseases created on the basis of the Republican Skin and Venereological Clinical Hospital the city of Tashkent, the Republican Specialized Scientific and Practical Center of Dermatology and Cosmetology of the Republic of Uzbekistan were studied. A retrospective analysis of case histories for the period 2015–2019 was also carried out at the clinical base of the Department of Dermatovenerology of the Tashkent Medical Academy.

RESULTS: The prevalence of psoriasis among the general population of the Republic of Uzbekistan from 2010 to 2020 during the study period significantly increased, especially in the age group of 15–29 years. Men suffer from psoriasis more often, this disease is characterized by an earlier onset of the disease (age group up to 40 years). The most common clinical form of psoriasis is vulgar psoriasis.

CONCLUSIONS: There is a clear need to improve the quality and increase the amount of data related to the epidemiology of psoriasis in the Republic of Uzbekistan. Diagnostic criteria and reports on morbidity and prevalence should be standardized.

Russian Journal of Skin and Venereal Diseases. 2022;25(2):127-132
pages 127-132 views
Оn the issue of diagnosis of Norwegian scabies on the example of a clinical case
Karacheva Y.V., Smykova A.N., Zeib A.V., Kovaleva Y.A., Yunevich A.S.
Abstract

Norwegian scabies is a rare form of a fairly common contagious skin disease. It is characterized by difficulties in diagnosis due to the absence of a typical clinical picture and characteristic complaints of the patient. Also, the diagnosis of Norwegian scabies is often complicated by the presence of concomitant diseases, such as ichthyosis and mental retardation. As a result of impaired cognitive functions in patients, it is quite problematic to collect complaints and anamnesis. An incorrect diagnosis leads to the appointment of ineffective therapy and, as a result, to further progression of the disease, accompanied by the addition of secondary infection and deterioration of the general condition of the patient’s body.

Training of doctors of various specialties (dermatovenerologists, therapists and general practitioners) in the skills of differential diagnosis of Norwegian scabies is relevant due to the increase in cases of this disease in various groups of people, mainly related to boarding houses and long-stay hospitals.

In this article, the authors provide an overview of the etiology, pathogenesis, and clinical manifestations of a rare form of scabies ― Norwegian scabies, and highlight the difficulties of differential diagnosis of this dermatosis. A clinical case of Norwegian scabies in a 52-year-old woman suffering from ichthyosis and mental retardation on the background of Down syndrome is described.

Russian Journal of Skin and Venereal Diseases. 2022;25(2):133-139
pages 133-139 views
Сlinical cases of newly diagnosed systemic lupus erythematosus at the appointment with a dermatologist
Morozova E.A., Bausheva E.A.
Abstract

Lupus erythematosus is a multisystemic connective tissue disease that has a wide range of manifestations affecting the skin and mucous membranes, joints, kidneys, heart, lungs, and central nervous system. In dermatology, cutaneous forms of lupus erythematosus can be classified into discoid, disseminated, centrifugal erythema, lupus panniculitis, subacute and chronic lupus, and systemic lupus erythematosus with damage to internal organs. It can develop as an independent disease or can be a result of progression of cutaneous forms.

The skin is the second most commonly affected organ in systemic lupus erythematosus folowing the joints, with skin manifestations observed in 80% of patients throughout the course of the disease. And in 20−30% of cases, the disease debuts with skin rash. Thus, these patients primarily present to dermatologists. Knowledge of the criteria for making a diagnosis, the clinical characteristics, in combination with performance of advanced laboratory diagnostic tests allow a dermatologist to suspect a systemic process in a timely manner and prescribe appropriate therapy.

The article presents two clinical observations of male patients with systemic lupus erythematosus, the diagnosis of which could not have been established for several years. The diagnosis in these cases met the 2019 European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR) classification criteria for systemic lupus erythematosus, confirmed by laboratory tests. Patients had a positive trend to response to therapy.

Russian Journal of Skin and Venereal Diseases. 2022;25(2):141-149
pages 141-149 views
Experience of using the 1,5% Tetranyl U cream in patients with tinea corporis and tinea cruris
Maximov I.S., Petukhova E.V.
Abstract

BACKGROUND: Over the past ten years, there has been a persistent increase in the resistance of dermatophytes to antifungal drugs. The development of new drugs and the evaluation of the effectiveness of medicines is a priority in mycology.

AIMS: Evaluation of the effectiveness and safety of using the cream containing Tetranyl U and 10% urea in the treatment of tinea corporis and tinea cruris.

MATERIALS AND METHODS: The study included 30 patients with a laboratory-confirmed diagnosis of tinea corporis and tinea cruris of mild to moderate severity. Patients were recommended to use the cream which was applied to the lesions 2 times a day for 3 weeks. The evaluation of the severity the course of mycosis and the effectiveness of the cream was carried out by calculating a 4-point PGA (Physician Global Assessment) before treatment and after 3 weeks of using the cream.

RESULTS: According to the results of the study, the clinical efficacy was 81.8%. Mycological response (negative direct microscopy + mycological culture) was achieved in 82.8% of patients.

CONCLUSION: The cream containing Tetranyl U showed good efficacy and tolerability in the treatment of tinea corporis and tinea cruris, which is confirmed by the results of clinical and microbiological studies.

Russian Journal of Skin and Venereal Diseases. 2022;25(2):151-158
pages 151-158 views

COSMETOLOGY

The dynamics of morphological and functional changes of face neck skin at using injectables
Khanalieva I.A.
Abstract

The article deals with the issues of face and neck skin involutional changes, which are considered to be the first and easily determined signs of the body aging. Clinical studies of the effectiveness of the therapy with medicines based on hyaluronic acid, silicon and zinc are presented. Based on the presented data, the possibility of further clinical trials of pharmacological preparations used to treat the skin of the face and neck is discussed.

Of particular interest are data on the dynamics of expression of key biomarkers of skin aging in the combined use of silicon- and zinc-containing injectable drugs. The addition of zinc can enhance the effect of silicon compounds in the composition of these drugs.

Organosilicon (silanol) increases the synthesis of type III collagen and elastin and has a protective effect against photodamage of the skin. An increase in the formation of type III collagen was revealed when using silicon complexes with chitinase, while an increase in the expression of TGF-β and an increase in fibroblast proliferation were also revealed.

The use of silicon- and zinc-containing drugs is a promising, but still insufficiently studied direction of therapy for involutional changes in the skin of the face and neck. Silicon and zinc in the composition of drugs for anti-aging therapy can have a synergistic effect, affecting a number of important molecular mechanisms of skin aging.

Russian Journal of Skin and Venereal Diseases. 2022;25(2):159-169
pages 159-169 views

CHRONICLES

Chronicles of A.I. Pospelov Moscow Dermatovenerology and Cosmetology Society (MDCS was founded on October 4, 1891) Bulletin of the MSDC
Yakovlev A.B., Maximov I.S.
Abstract

The 1147th meeting was held in a face-to-face format. In total there were 95 participants. Four people were accepted as members of the MSDC.

Among the clinical observations presented at the meeting were patients with psoriatic erythroderma (two cases) and erythroderma in Deverji’s disease. Erythroderma is a severe, often life threatening condition characterized by a universal inflammatory lesion of the skin, itching, generalized lymphadenopathy and fever. A case of cryoglobulinemic vasculitis, characterized by polymorphism of the course and a tendency to necrosis, is also presented in a 65-year-old patient who developed drug-induced Itsenko–Cushing syndrome during treatment. A case of multiform exudative erythema was also considered in a 40-year-old patient with abundant rashes on the skin of the trunk and extremities caused by subacute SARS-CoV-2-associated myocarditis of high immunological activity, moderate course.

The topics of scientific reports were devoted to auto-inflammatory syndrome (SAPHO; PEPA; PUSH; PUSH) and acne. It has been reported that biological anticytokine therapy ― IL-1 antagonists ― is the most acceptable for the treatment of all syndromes with the main dermatological manifestation in the form of acne. For severe forms of acne, an algorithm for patient management was proposed.

Russian Journal of Skin and Venereal Diseases. 2022;25(2):171-175
pages 171-175 views

PHOTO GALLERY

Photogallery. Metabolic dermatoses
Grabovskaya O.V., Teplyuk N.P., Kolesova Y.V.
Abstract

Metabolic dermatoses are signs of some internal diseases, which makes it possible to identify them before clinical manifistation. Thus amyloidosis is often associated with Familial Mediterranean fever, and its timely diagnosis contributes to the detection of diseases such as medullary thyroid cancer, multiple myeloma, Waldenstrom macroglobulinemia and other monoclonal gammopathy, nephropathy, generalized sensorimotor polyneuropathy, dysfunction of the gastrointestinal tract, etc. Necrobiosis lipoidica is associated with diabetes mellitus, mucinosis ― with thyroid diseases, xanthomas ― with histiocytosis X, porphyria ― with liver disease, calcinosis ― with abnormality calcium metabolism.

Russian Journal of Skin and Venereal Diseases. 2022;25(2):177-180
pages 177-180 views


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