Vol 14, No 5 (2011)

Authors present data about genotyping studies in dermatology illustrating the main applications and practical importance of genetic analyses for dermatologists.

Literature data (45 Russian and foreign papers) as well own experience of treatment of different forms of Darrier disease in 12 patients. Peculiarities of the disease course and therapy are discussed.

Authors carried out a comparative assessment of comorbid metabolic syndrome (MS) on a clinical course, severity of disorders of porphyrin, lipid, and carbohydrate metabolism in patients with porphyria cutanea tarda (PCT). Sample included 34 patients (31 men and 3 women) from 33 to 68 years old (mean age 48 ± 2,1 y.o.). In 20 patients (main group) MS was diagnosed which was associated with hepatitis C virus infection (HCV). The comparison group included 14 patients without any signs of MS. The examination revealed no significant influence of MS on a clinical course and dermatological manifestation of PCT. But in patients with MS cardiovascular disorders were more often present, as well as disorders of lipid and carbohydrate metabolism along with higher levels of uroporphyrin in urine. The additive effect of MS and HCV infection on a liver function is unfavourable. As a rule, patients with PCT and MS have comorbid polyorgan pathology and should be treated as patients with higher risk of coronary complications and diabetes mellitus II.

In order to increase efficiency and safety of treatment of atopic dermatitis among children and adults modern glucocorticosteroid ointment methylprednisolone aceponate is offered for drug phonophoresis method.

Authors present a review of russian and foreign literature (22 papers) concerning etiology, pathogenesis, classification, diagnosis and treatment of bullous epidermolysis. A case of congenital dystrophic bullous epidermolysis in a 15 years old patient is described.

Etiology, pathogenesis, clinical and histopathologic diagnostic criteria as well as therapeutic approach to Gronblad-Strandberg syndrome are discussed. A case of Gronblad-Strandberg syndrome is presented. The disorder manifested in 47 years old patient with disseminated pseudoxantoma elasticum on a skin of neck, axillae, and other zones as well as angioid stripes in Bruch's membrane and lower legs arteries affection.

Authors present two cases of such rare disorder as inherited ichthyosis in newborns, successfully treated in in-patient department. Current literature data concerning etiology, pathogenesis, clinical presentation and therapy of inherited ichthyosis are also presented.

Genodermatoses - a problem, which needs more detailed investigations and organization of patients rehabilitation. During the last 15 years in Primorye territory 58 cases of genodermatoses were detected. Ar the same time genodermatoses are still rarely timely diagnosed because of heterogeneity of clinical presentation. Besides that, as a rule these patients stay for follow up by non-dermatologists. Obviously such situation is a result of insufficient knowledge in this field and luck of communication between detmatologists and other specialists, shortage of guidance materials and guidelines on genodermatoses for practicing specialists of health service. Several cases of Werner syndrome and inherited psoriasis are presented.

For the purpose of research of agents for treatment of skin diseases, accompanied by skin dryness, an assessment of clinical effectivity of "Aysida" preparations (cream-gel for dry and sensitive skin). The cream-gel was applied in patients after the main treatment course for moderate to severe atopic dermatitis (AD), and as main treatment preparation for mild AD and skin xerosis