The interrelation of seborrheic dermatitis with facial skin lesions with metabolic syndrome and diabetes mellitus

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

BACKGROUND: In recent decades, interest in the role of metabolic syndrome and its impact on dermatological pathology has been steadily increasing. One of the pathogenetic components of the metabolic syndrome is inflammation, and many pro-inflammatory factors play a crucial role in the development of this disease. However, the interrelation between the metabolic syndrome and facial skin lesions in seborrheic dermatitis remains not fully understood.

AIMS: To identify a possible association of seborrheic dermatitis with the involvement of the skin of the face with metabolic syndrome and diabetes mellitus.

MATERIAL AND METHODS: The study included 45 patients with seborrheic dermatitis, divided into 3 groups (patients with seborrheic dermatitis, patients with seborrheic dermatitis and metabolic syndrome, and patients with seborrheic dermatitis, metabolic syndrome and diabetes mellitus). The severity of the disease was determined by the lesion area and the seborrheic dermatitis severity index (SEDASI). The metabolic syndrome was diagnosed based on the NCEP ATP III criteria.

RESULTS: When assessing the severity of seborrheic dermatitis of the face and scalp, it was found that in group 1, a mild degree was observed in all (100%) patients. In group 2, 7 (46.7%) patients had moderate lesion and 8 (53.3%) patients had severe lesion. In group 3, a moderate degree of the disease was observed in 10 (82%) patients and severe in 5 (18%) patients. A positive correlation was found between the indices of metabolic syndrome and the severity of seborrheic dermatitis with facial skin lesions. A significant correlation was shown between the level of triglycerides and the number of anatomical zones involved in the process (r=0.74; p <0.01). In patients of groups 2 and 3, a direct interrelation was established between low levels of HDL, high levels of LDL and the severity of SD of the face (r=0.379; p=0.76), (r=0.321, p=0.037).

CONCLUSION: The severity of the course and spread of seborrheic dermatitis on the face can serve as a diagnostic marker of metabolic syndrome and diabetes mellitus. An increase in the level of LDL and triglycerides, a decrease in the level of HDL, and insulin resistance are associated with a severe course of seborrheic dermatitis in a person, playing a significant role in the pathogenesis of the disease.

Full Text

Restricted Access

About the authors

Kristina Yu. Molodykh

Academician I.P. Pavlov First St. Petersburg State Medical University

Author for correspondence.
Email: molodyhkristina@mail.ru
SPIN-code: 9472-9640

MD, Assistant Lecturer

Russian Federation, St. Petersburg

Elena R. Araviiskaia

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: arelenar@mail.ru
ORCID iD: 0000-0002-6378-8582
SPIN-code: 9094-9688

MD, Dr. Sci. (Med.), Professor

Russian Federation, 6/8, Lva Tolstogo street, St. Petersburg, 197089

Evgeny V. Sokolovskiy

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: s40@mail.ru
ORCID iD: 0000-0001-7610-6061
SPIN-code: 6807-7137

MD, Dr. Sci. (Med.), Professor

Russian Federation, 6/8, Lva Tolstogo street, St. Petersburg, 197089

References

  1. Guide to dermatocosmetology. Ed. by E.R. Araviyskaya, E.V. Sokolovsky. Saint Petersburg: Folio; 2008. Р. 261–265. (In Russ).
  2. Tamer F, Yuksel ME, Sarifakioglu E, Karabag Y. Staphylococcus aureus is the most common bacterial agent of the skin flora of patients with seborrheic dermatitis. Dermatol Pract Concept. 2018;8(2):80–84. doi: 10.5826/dpc.0802a04
  3. Laurence M, Benito-León J, Calon F. Malassezia and Parkinson’s disease. Front Neurol. 2019;10:758. doi: 10.3389/fneur.2019.00758
  4. Moreno-Coutiño G, Sánchez-Cárdenas C, Bello-Hernández Y, et al. Isolation of Malassezia spp. In HIV-positive patients with and without seborrheic dermatitis. An Bras Dermatol. 2019;94(5):527–531. doi: 10.1016/j.abd.2019.09.012
  5. Dessinioti C, Katsambas A. Seborrheic dermatitis: etiology, risk-factors and treatments: facts and controversies. Clin Dermatol. 2013;31(4):343–351. doi: 10.1016/j.clindermatol.2013.01.001
  6. İmamoğlu B, Hayta S, Güner R, et al. Metabolic syndrome may be an important comorbidity in patients with seborrheic dermatitis. Arch Med Sci Atheroscler Dis. 2016;1(1):e158–e161. doi: 10.5114/amsad.2016.65075
  7. McCracken E, Monaghan M, Sreenivasan S. Pathophysiology of the metabolic syndrome. Clin Dermatol. 2018;36(1):14–20. doi: 10.1016/j.clindermatol.2017.09.004
  8. Popov K.A. Features of biochemical blood parameters in the combined course of type 2 diabetes mellitus with dermatological diseases. National Health. 2017;(1–2):112–18.
  9. Karabay E, Çerman A. Demodex folliculorum infestations in common facial dermatoses: acne vulgaris, rosacea, seborrheic dermatitis. An Bras Dermatol. 2020;95(2):187–193. doi: 10.1016/j.abd.2019.08.023
  10. Borda LJ, Wikramanayake TC. seborrheic dermatitis and dandruff: a comprehensive review. J Clin Investig Dermatol. 2015;3(2):10.13188/2373-1044.1000019. doi: 10.13188/2373-1044.1000019
  11. Rahimi S, Nemati N, Shafaei-Tonekaboni SS. Serum levels of 25-hydroxyvitamin D in patients with seborrheic dermatitis: a case-control study. Dermatol Res Pract. 2021;2021:6623271. doi: 10.1155/2021/6623271
  12. Shenoy Ch, Shenoy MM, Rao GK. Dyslipidemia in dermatological disorders. N Am J Med Sci. 2015;7(10):421–428. doi: 10.4103/1947-2714.168657
  13. Karincaoglu Y, Tepe B, Kalayci B, et al. Is demodex folliculorum an aetiological factor in seborrhoeic dermatitis? Clin Exp Dermatol. 2009;34(8):e516–e520. doi: 10.1111/j.1365-2230.2009.03343.x
  14. Micali G, Lacarrubba L, Dall’Oglio F, et al. A new proposed severity score for seborrheic dermatitis of the face: Seborrheic Dermatitis Area and Severity Index (SEDASI). J Am Academy Dermatolog. 2017;76(6):AB18.
  15. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106(25):3143–3421.
  16. Hu Y, Zhu Y, Lian N, et al. Metabolic syndrome and skin diseases. Front Endocrinol (Lausanne). 2019;10:788. doi: 10.3389/fendo.2019.00788
  17. Gelfand JM, Yeung H. Metabolic syndrome in patients with psoriatic disease. J Rheumatol Suppl. 2012;89:24–28. doi: 10.3899/jrheum.120237
  18. Furue M, Tsuji G, Chiba T, Kadono T. Cardiovascular and metabolic diseases comorbid with psoriasis: beyond the skin. Intern Med. 2017;56(13):1613–1619. doi: 10.2169/internalmedicine.56.8209
  19. Uczniak S, Gerlicz ZA, Kozlowska M, Kaszuba A. Presence of selected metabolic syndrome components in patients with psoriasis vulgaris. Postepy Dermatol Alergol. 2016;33(2):114–119. doi: 10.5114/ada.2016.59153
  20. Teslime A, Serap BŞ, Osman ZŞ. Relation of acanthosis nigricans to metabolic syndrome in overweight and obese women. Metab Syndr Relat Disord. 2014;12(6):320–323. doi: 10.1089/met.2013.0145
  21. Phiske MM. An approach to acanthosis nigricans. Indian Dermatol J. 2014;5(3):239–249. doi: 10.4103/2229-5178.137765
  22. Rasi A, Soltani-Arabshahi R, Shahbazi N. Skin tag as a cutaneous marker for impaired carbohydrate metabolism: a case-control study. Int J Dermatol. 2007;46(11):1155–1159. doi: 10.1111/j.1365-4632.2007.03287.x
  23. Shenoy C, Shenoy MM, Krishna S, Pinto M. Skin tags are not merely cosmetic: a study on its association with metabolic syndrome. Int J Health Allied Sci. 2016;5:50–52. doi: 10.4103/2278-344X.173882

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Characteristics of the clinical picture of seborrheic dermatitis of the face in patients, n.

Download (128KB)
Indexing metadata
3. Fig. 2. Characteristics of facial skin lesions in seborrheic dermatitis, depending on the location.

Download (92KB)
Indexing metadata

Copyright (c) 2021 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 86501 от 11.12.2023 г. 
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 80653 от 15.03.2021 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies