Email this article Study of the efficiency of a peptide-based cosmetic product in topical therapy for diffuse alopecia
- Authors: Korolkova T.N.1, Kharitonova E.E.1, Shepilova I.A.1, Nesterovich D.S.2
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Affiliations:
- North-Western State Medical University n.a. I.I. Mechnikov
- Vernadsky Institute of Geochemistry and Analytical Chemistry
- Issue: Vol 23, No 3 (2020)
- Pages: 188-193
- Section: COSMETOLOGY
- URL: https://rjsvd.com/1560-9588/article/view/48904
- DOI: https://doi.org/10.17816/dv48904
- ID: 48904
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Abstract
Background: Hair loss is a significant health problem; hence, individuals experiencing hair loss immediately visit a doctor for treatment. Diffuse (symptomatic) alopecia can be the result of various external and internal factors. A doctor should determine the cause of the hair loss and prescribe treatment, including topical agents.
Aim: to study the clinical efficacy of hair spray with peptides in the treatment of patients with diffuse alopecia and its effect on the trichogramma parameters.
Materials and methods: Thirty female patients with diffuse alopecia, aged from 18 to 59 years, were monitored in the Center of Medical Cosmetology of the I.I. Mechnikov North-Western State Medical University. In a controlled comparative study, the patients were divided into two equal groups. In group 1 (main), the drug of choice was a spray based on peptides; while in group 2 (comparison), a cosmetic product based on enzymes was applied. The drugs were used topically for 3 months. Patients were examined using questionnaires (objective assessment by the doctor and subjective evaluation by the patient) and photographs and by assessing the morphometric parameters of hair growth before treatment, 3 months after the start of treatment, and 1 month after treatment termination.
Results: In group 1, in the parietal zone, the hair density increased significantly by 19% after 3 months and by 23% after 4 months. The number of anagen hair increased by 8% after 3 months and by 16% after 4 months, with a corresponding decrease in the number of telogen hair compared to the initial level. In the occipital zone, the number of anagen hair increased by 7% after 3 months and by 13% after 4 months, with the corresponding dynamics of telogen hair compared to the initial level. The cosmetic product has been shown to be tolerated well, and no allergic reactions were noted.
Conclusion: The peptide-based spray can be recommended for patients with diffuse alopecia as a topical therapy.
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About the authors
Tatiana N. Korolkova
North-Western State Medical University n.a. I.I. Mechnikov
Author for correspondence.
Email: tnkor@mail.ru
ORCID iD: 0000-0001-7190-411X
MD, PhD, DSc, Professor, Head of the Department of Cosmetology of North-Western State Medical University n.a. I.I. Mechnikov
Russian Federation, St PetersburgE. E. Kharitonova
North-Western State Medical University n.a. I.I. Mechnikov
Email: tnkor@mail.ru
ORCID iD: 0000-0001-5838-5466
Russian Federation, St Petersburg
I. A. Shepilova
North-Western State Medical University n.a. I.I. Mechnikov
Email: tnkor@mail.ru
ORCID iD: 0000-0002-4147-9789
Russian Federation, St Petersburg
D. S. Nesterovich
Vernadsky Institute of Geochemistry and Analytical Chemistry
Email: tnkor@mail.ru
ORCID iD: 0000-0003-3837-9362
Russian Federation, Moscow
References
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- Uryupina EL, Malishevskaya NP. The condition of the psychoemotional status in patients with diffuse telogen hair loss. Russian Journal of Skin and Venereal Diseases. 2017;20(5):285-9. (in Russian)
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