Study of the efficiency of a peptide-based cosmetic product in topical therapy for diffuse alopecia
- 作者: Korolkova T.N.1, Kharitonova E.E.1, Shepilova I.A.1, Nesterovich D.S.2
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隶属关系:
- North-Western State Medical University n.a. I.I. Mechnikov
- Vernadsky Institute of Geochemistry and Analytical Chemistry
- 期: 卷 23, 编号 3 (2020)
- 页面: 188-193
- 栏目: COSMETOLOGY
- ##submission.dateSubmitted##: 02.11.2020
- ##submission.dateAccepted##: 02.11.2020
- ##submission.datePublished##: 15.06.2020
- URL: https://rjsvd.com/1560-9588/article/view/48904
- DOI: https://doi.org/10.17816/dv48904
- ID: 48904
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详细
Background: Hair loss is a significant health problem; hence, individuals experiencing hair loss immediately visit a doctor for treatment. Diffuse (symptomatic) alopecia can be the result of various external and internal factors. A doctor should determine the cause of the hair loss and prescribe treatment, including topical agents.
Aim: to study the clinical efficacy of hair spray with peptides in the treatment of patients with diffuse alopecia and its effect on the trichogramma parameters.
Materials and methods: Thirty female patients with diffuse alopecia, aged from 18 to 59 years, were monitored in the Center of Medical Cosmetology of the I.I. Mechnikov North-Western State Medical University. In a controlled comparative study, the patients were divided into two equal groups. In group 1 (main), the drug of choice was a spray based on peptides; while in group 2 (comparison), a cosmetic product based on enzymes was applied. The drugs were used topically for 3 months. Patients were examined using questionnaires (objective assessment by the doctor and subjective evaluation by the patient) and photographs and by assessing the morphometric parameters of hair growth before treatment, 3 months after the start of treatment, and 1 month after treatment termination.
Results: In group 1, in the parietal zone, the hair density increased significantly by 19% after 3 months and by 23% after 4 months. The number of anagen hair increased by 8% after 3 months and by 16% after 4 months, with a corresponding decrease in the number of telogen hair compared to the initial level. In the occipital zone, the number of anagen hair increased by 7% after 3 months and by 13% after 4 months, with the corresponding dynamics of telogen hair compared to the initial level. The cosmetic product has been shown to be tolerated well, and no allergic reactions were noted.
Conclusion: The peptide-based spray can be recommended for patients with diffuse alopecia as a topical therapy.
全文:
作者简介
Tatiana Korolkova
North-Western State Medical University n.a. I.I. Mechnikov
编辑信件的主要联系方式.
Email: tnkor@mail.ru
ORCID iD: 0000-0001-7190-411X
MD, PhD, DSc, Professor, Head of the Department of Cosmetology of North-Western State Medical University n.a. I.I. Mechnikov
俄罗斯联邦, St PetersburgE. Kharitonova
North-Western State Medical University n.a. I.I. Mechnikov
Email: tnkor@mail.ru
ORCID iD: 0000-0001-5838-5466
俄罗斯联邦, St Petersburg
I. Shepilova
North-Western State Medical University n.a. I.I. Mechnikov
Email: tnkor@mail.ru
ORCID iD: 0000-0002-4147-9789
俄罗斯联邦, St Petersburg
D. Nesterovich
Vernadsky Institute of Geochemistry and Analytical Chemistry
Email: tnkor@mail.ru
ORCID iD: 0000-0003-3837-9362
俄罗斯联邦, Moscow
参考
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- Dribnokhod YuYu. Hair treatment in cosmetology. St. Petersburg: SpetsLit; 2015. (in Russian)
- Adaskevich VP, Myadelets OD, Tikhonovskaya IV. Alopecia. Moscow: Medical book; 2000. (in Russian)
- Uryupina EL, Malishevskaya NP. The condition of the psychoemotional status in patients with diffuse telogen hair loss. Russian Journal of Skin and Venereal Diseases. 2017;20(5):285-9. (in Russian)
- Simbirtsev AS. Prospects for the use of preparations of cytokines in dermatovenereology. Practical Medicine. Russian Journal. 2011;49(2):15-2. (in Russian)