ATYPICAL FIBROXANTHOMA OF THE SKIN



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详细

Atypical fibroxanthoma (AFX) is a rare skin tumour related to the group of fibrohistiocytic tumours. The tumour is most often occurs in elderly people against the background of photodamage of the skin. As a rule, it is located in the area of the head, shoulders, upper third of the back. It is typical of local destructive growth and extremely rare metastasis. However, in patients, against the background of immunosuppression, aggressive behaviour of this tumor is possible. The similarity of atypical fibroxanthoma with such aggressive tumours as amelanotic melanoma and Merkel's carcinoma poses a problem for the clinician. The diagnosis can be reliably made based solely on characteristic histological and immunohistochemical findings. We present a case of this tumour in a 72-year-old patient with photodamaged skin in combination with other skin tumours.

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作者简介

Diana Khorosheva

Первый Московский государственный медицинский университет имени И.М. Сеченова

编辑信件的主要联系方式.
Email: 5_97@inbox.ru
ORCID iD: 0009-0006-1296-5848

Клинический ординатор

俄罗斯联邦

Ekaterina Vertieva

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: ivertieva@gmail.com
ORCID iD: 0000-0002-1088-2911
SPIN 代码: 3712-8453

MD, Cand. Sci. (Med.)

俄罗斯联邦, Moscow

Alexander Tertychnyy

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: atertychyy@gmail.com
ORCID iD: 0000-0001-5635-6100
SPIN 代码: 5150-0535

MD, Cand. Sci. (Med.)

俄罗斯联邦, Moscow

Larisa Tsoy

ФГАОУ ВО Первый МГМУ имени И.М. Сеченова Минздрава России (Сеченовский Университет)

Email: dr.lvtsoy@gmail.com
ORCID iD: 0000-0001-9072-2311
SPIN 代码: 9581-6228

Tatiana Bocharova

СГМУ Им. В.И.Разумовского

Email: tatuana.bocharova@yandex.ru
ORCID iD: 0009-0002-4361-1357

参考

  1. Rosenfeld D, Alam M, Van Tine B, Council ML. Atypical fibroxanthoma: a malignant tumor of the skin and soft tissue. J Am Acad Dermatol. 2020;83(6):e429-e430 doi: 10.1016/j.jaad.2020.07.022
  2. Agaimy A. The many faces of atypical fibroxanthoma. Semin Diagn Pathol. 2023;40(4):306-312 doi: 10.1053/j.semdp.2023.06.001
  3. Ríos-Viñuela E, Pons Benavent M, Monteagudo C, Nagore E, Sanmartín O. Atypical fibroxanthoma and pleomorphic dermal sarcoma: a two-center retrospective study of 74 cases. Actas Dermosifiliogr. 2022;113(6):654-656 doi: 10.1016/j.ad.2021.09.008
  4. Helwig EB, May D. Atypical fibroxanthoma of the skin with metastasis. Cancer. 1986;57(2):368-376 doi: 10.1002/1097-0142(19860115)57:2<368::aid-cncr2820570230>3.0.co;2-n
  5. Bitel A, Schönlebe J, Krönert C, Wollina U. Atypical fibroxanthoma: an analysis of 105 tumors. Dermatol Ther. 2020;33(6):e13962 doi: 10.1111/dth.13962
  6. Pitarch G. Dermoscopic rainbow pattern in atypical fibroxanthoma. Actas Dermosifiliogr. 2014;105(1):97-99 doi: 10.1016/j.ad.2012.11.010
  7. Alves R, Ocaña J, Vale E, Correia S, Viana I, Bordalo O. Basal cell carcinoma and atypical fibroxanthoma: an unusual collision tumor. J Am Acad Dermatol. 2010;63(3):e74-e76 doi: 10.1016/j.jaad.2009.11.685
  8. Fisher JC, Jones M, Hurd DS. Atypical fibroxanthoma: a case report and literature review. J Am Osteopath Coll Dermatol. 2017;37(2):17-19.
  9. Piras V, Ferreli C, Atzori L, Pinna G, Pilloni L. Atypical fibroxanthoma/pleomorphic dermal sarcoma of the scalp with aberrant expression of HMB-45: a pitfall in dermatopathology. Pathologica. 2020;112(2):105-109 doi: 10.32074/1591-951X-39-19
  10. Nguyen CM, Chong K, Cassarino D. Clear cell atypical fibroxanthoma: a case report and review of the literature. J Cutan Pathol. 2016;43(6):538-542 doi: 10.1111/cup.12696

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