The role of vitamins and micronutrients in the pathogenesis and treatment of vitiligo

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The active interest of research in the topic of vitiligo is due to the increased possibility of treating this dermatosis of unknown etiology and its high psycho-emotional significance, concerning not only a certain individual, but also affecting society as a whole. The review examines the role of vitamins and micronutrients in the pathogenesis of vitiligo and possible comprehensive approaches to treatment taking into account these elements.

Aim: to evaluate the effect of vitamins and micronutrients on the course and development of vitiligo, and also to consider the advisability of their use in the treatment of patients with vitiligo.

A literary review of the PubMed, Cochrane Library, CyberLeninka, Clinicaltrial.gov and the Internet databases was conducted to study the role of specific microelements and vitamins involved in metabolic processes in the development of vitiligo disease.

Based on literature data, we can conclude that vitiligo by etiopathogenesis refers to multifactorial skin diseases, the final consequences of which is the cessation melanogenesis in certain areas of the skin. In all situations, one of the main factors is a metabolic disorder associated with the endoecology of the body. Vitamins and micronutrients play an important role in the pathogenetic chain of vitiligo. Thus, the introduction of individual micronutrients and vitamins into complex therapy of vitiligo seems extremely relevant and promising.

Full Text

Restricted Access

About the authors

Marina V. Alekseeva

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: meri.alekseeva@gmail.com
ORCID iD: 0009-0008-0931-2701
Russian Federation, Moscow

Alina E. Ryzhkova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: lina_ryzhkova@list.ru
ORCID iD: 0009-0006-5509-3250
Russian Federation, Moscow

Adelina A. Tsyganova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: adelina.tsy@mail.ru
ORCID iD: 0009-0006-7696-3008
SPIN-code: 6800-4550
Russian Federation, Moscow

Kristina A. Myzina

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: bashlakova_kristina@mail.ru
ORCID iD: 0000-0002-9628-0523
SPIN-code: 9259-6459

MD, Cand. Sci. (Medicine)

Russian Federation, Moscow

Konstantin M. Lomonosov

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: lamclinic@yandex.ru
ORCID iD: 0000-0002-4580-6193
SPIN-code: 4784-9730

MD, Dr. Sci. (Medicine), Professor

Russian Federation, Moscow

References

  1. Kubanov AA, Zhilova MB, Abramova TV. Dermatovenerology. Federal clinical recommendation of vitiligo. Moscow; 2020. (In Russ).
  2. Gill L, Zarbo A, Isedeh P, et al. Comorbid autoimmune diseases in patients with vitiligo: A cross-sectional study. J Am Acad Dermatol. 2016;74(2):295–302. doi: 10.1016/j.jaad.2015.08.063
  3. Alkhateeb A, Fain PR, Thody A, et al. Epidemiology of vitiligo and associated autoimmune diseases in caucasian probands and their families. Pigment Cell Res. 2003;16(3):208–214. EDN: BGVFZB doi: 10.1034/j.1600-0749.2003.00032.x
  4. Olisova OY, Nikulina AS, Krotkova EA, et al. Possibilities of microneedling in the combined therapy of vitiligo. literature review. Russ J Skin Venereal Dis = Rossiiskii zhurnal kozhnykh i venericheskikh boleznei. 2022;25(5):363–371. EDN: IFFZVL doi: 10.17816/dv111066
  5. Bagherani N, Yaghoobi R, Omidian M. Hypothesis: Zinc can be effective in treatment of vitiligo. Indian J Dermatol. 2011;56(5):480–484. doi: 10.4103/0019-5154.87116
  6. Shameer P., Prasad P.V., Kaviarasan P.K. Serum zinc level in vitiligo: A case control study. Indian J Dermatol Veneol Leprol. 2005;71(3):206–207. doi: 10.4103/0378-6323.16243
  7. Arora PN, Dhillon KS, Rajan SR, et al. Serum zinc level in cutaneous disorders. Med J Armed Forces. 2002;58(4):304–306. doi: 10.1016/S0377-1237(02)80083-1
  8. Inamadar AC, Palit A. Acrodermatitis entropathica with depigmented skin lesions simulating vitiligo. Pediatr Dermatol. 2007;24(6):668–669. doi: 10.1111/j.1525-1470.2007.00567.x
  9. Zatt P, Zambenedetti P, Witkowski W, Carpené E. Localization of metallothionein I–II immunoreactivity in bovine pituitary gland. Life Sci. 2001;70(6):659–667. doi: 10.1016/s0024-3205(01)01444-8
  10. Osredkar J, Sustar N. Copper and zinc, biological role and signi cance of copper/zinc imbalance. J Clinic Toxicol. 2011;1(S3):2–18. doi: 10.4172/2161-0495.S3-001
  11. Khoshdel Z, Gholijani N, Niknam M, et al. Serum copper and zinc levels among Iranian vitiligo patients. Dermatol Pract Concept. 2022;12(4):e2022140. EDN: TTGVEQ doi: 10.5826/dpc.1204a140
  12. Zeng Q, Yin J, Fan F, et al. Decreased copper and zinc in sera of chinese vitiligo patients: A meta-analysis. J Dermatol. 2014;41(3):245–251. doi: 10.1111/1346-8138.12392
  13. Yaghoobi R, Omidian M, Bagherani N. Original article title: Comparison of therapeutic efficacy of topical corticosteroid and oral zinc sulfate-topical corticosteroid combination in the treatment of vitiligo patients: A clinical trial. BMC Dermatol. 2011;11:7. doi: 10.1186/1471-5945-11-7
  14. Smith MK, Mohammad TF, Hamzavi IH. Assessment of dietary supplementation in the treatment of vitiligo. Open Dermatol J. 2017;11(1):12–21. doi: 10.2174/1874372201711010012
  15. Deleuran B, Abraham DJ. Possible implication of the effector CD4+ T-cell subpopulation Th17 in the pathogenesis of systemic scleroderma. Nat Clin Pract Rheumatol. 2007;3(12):682–683. doi: 10.1038/ncprheum0618
  16. Birlea SA, Costin GE, Norris DA. New insights on therapy with vitamin D analogs targeting the intracellular pathways that control repigmentation in human vitiligo. Med Res Rev. 2009;29(3):514–546. doi: 10.1002/med.20146
  17. Oh SH, Kim T, Jee H, et al. Combination treatment of non-segmental vitiligo with a 308-nm xenon chloride excimer laser and topical high-concentration tacalcitol: A prospective, single-blinded, paired, comparative study. J Am Acad Dermatol. 2011;65(2):428–430. doi: 10.1016/j.jaad.2010.12.007
  18. Koizumi H, Kaplan A, Shimizu T, Ohkawara A. 1,25-Dihydroxyvitamin D3 and a new analogue, 22-oxacalcitriol, modulate proliferation and interleukin-8 secretion of normal human keratinocytes. J Dermatol Sci. 1997;15(3):207–213. doi: 10.1016/s0923-1811(97)00609-9
  19. Al-Ghamdi K, Kumar A, Moussa N. He role of vitamin D in melanogenesis with an emphasis on vitiligo. Indian J Dermatol Venereol Leprol. 2013;79(6):750–758. doi: 10.4103/0378-6323.120720
  20. Silverberg JI. A pilot study assessing the role of 25 hydroxy vitamin D levels in patients with vitiligo vulgaris. J Am Acad Dermatol. 2010;62(6):937–941. doi: 10.1016/j.jaad.2009.11.024
  21. Sehrawat M, Arora TC, Chauhan A, et al. Correlation of vitamin D levels with pigmentation in vitiligo patients treated with NBUVB therapy. ISRN Dermatol. 2014;2014:493213. doi: 10.1155/2014/493213
  22. Mahmmod Z, Ismael DK. Vitamin D deficiency in patients with vitiligo: A cross-sectional study from Basrah, Iraq. Cureus. 2021;13(12):e20733. doi: 10.7759/cureus.20733
  23. Finamor DC, Sinigaglia-Coimbra R, Neves LC, et al. A pilot study assessing the effect of prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis. Dermatoendocrinol. 2013;5(1):222–234. doi: 10.4161/derm.24808
  24. Parsad D, Saini R, Verma N. Combination of PUVA sol and topical calcipotriol in vitiligo. Dermatology. 1998;197(2):167–170. doi: 10.1159/000017991
  25. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266–281. doi: 10.1056/NEJMra070553
  26. Montes LF, Diaz ML, Lajous J, Garcia NJ. Folic acid and vitamin B12 in vitiligo: A nutritional approach. Cutis. 1992;50(1):39–42.
  27. Juhlin L, Olsson MJ. Improvement of vitiligo after oral treatment with vitamin B12 and folic acid and the importance of sun exposure. Acta Derm Venereol. 1997;77(6):460–462. doi: 10.2340/000155555577460462
  28. Xing X, Dan Y, Xu Z, Xiang L. Implications of oxidative stress in the pathogenesis and treatment of hyperpigmentation disorders. Oxid Med Cell Longev. 2022;2022:7881717. EDN: QZZIWL doi: 10.1155/2022/7881717
  29. Dutta RR, Kumar T, Ingole N. Diet and vitiligo: The story so far. Cureus. 2022;14(8):e28516. EDN: PZHNHO doi: 10.7759/cureus.28516
  30. Sardana K, Sachdeva S. Role of nutritional supplements in selected dermatological disorders: A review. J Cosmet Dermatol. 2022;21(1):85–98. doi: 10.1111/JOCD.14436
  31. Liu X, Yang G, Luo M, et al. Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis. PLoS One. 2021;16(12):e0261259. EDN: NSHAOC doi: 10.1371/JOURNAL.PONE.0261259
  32. Akyol M, Celik VK, Ozcelik S, et al. The effects of vitamin E on the skin lipid peroxidation and the clinical improvement in vitiligo patients treated with PUVA. Eur J Dermatol. 2002;12(1):24–26. EDN: LTPTQJ
  33. Elgoweini M, Din NN. Response of vitiligo to narrowband ultraviolet B and oral antioxidants. J Clin Pharmacol. 2009;49(7):852–855. EDN: NTFVTR doi: 10.1177/0091270009335769
  34. Dell’Anna ML, Mastrofrancesco A, Sala R, et al. Antioxidants and narrow band-UVB in the treatment of vitiligo: A double-blind placebo controlled trial. Clin Exp Dermatol. 2007;32(6):631–636. doi: 10.1111/J.1365-2230.2007.02514.X
  35. Nowowiejska L, Marek-Józefowicz L, Szewczyk-Golec K, et al. Influence of oral supplementation of vitamins A and E on the effectiveness of vitiligo treatment. Dermatol Ther. 2023;2023(5): 3777109. doi: 10.1155/2023/3777109

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2024 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 86501 от 11.12.2023 г. 
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 80653 от 15.03.2021 г.