Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal DiseasesРоссийский журнал кожных и венерических болезней1560-95882412-9097Eco-Vector63018910.17816/dv630189DERMATOLOGYДЕРМАТОЛОГИЯReview ArticleThe role of vitamins and micronutrients in the pathogenesis and treatment of vitiligoРоль витаминов и микроэлементов в патогенезе и лечении витилигоhttps://orcid.org/0009-0008-0931-2701AlekseevaMarina V.АлексееваМарина Владиславовна
Russian Federation
meri.alekseeva@gmail.comhttps://orcid.org/0009-0006-5509-3250RyzhkovaAlina E.РыжковаАлина Евгеньевна
Russian Federation
lina_ryzhkova@list.ruhttps://orcid.org/0009-0006-7696-30086800-4550TsyganovaAdelina A.ЦыгановаАделина Александровна
Russian Federation
adelina.tsy@mail.ruhttps://orcid.org/0000-0002-9628-05239259-6459MyzinaKristina A.МызинаКристина Александровна
Russian Federation

MD, Cand. Sci. (Medicine)

канд. мед. наук

bashlakova_kristina@mail.ruhttps://orcid.org/0000-0002-4580-61934784-9730LomonosovKonstantin M.ЛомоносовКонстантин Михайлович
Russian Federation

MD, Dr. Sci. (Medicine), Professor

д-р мед. наук, профессор

lamclinic@yandex.ruI.M. Sechenov First Moscow State Medical University (Sechenov University)Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)02112024011220242756016080904202420092024Copyright ©; 2024, Eco-VectorCopyright ©; 2024, Эко-Вектор2024Eco-VectorЭко-Векторhttps://rjsvd.com/1560-9588/article/view/630189

The active interest of research in the topic of vitiligo is due to the increased possibility of treating this dermatosis of unknown etiology and its high psycho-emotional significance, concerning not only a certain individual, but also affecting society as a whole. The review examines the role of vitamins and micronutrients in the pathogenesis of vitiligo and possible comprehensive approaches to treatment taking into account these elements.

Aim: to evaluate the effect of vitamins and micronutrients on the course and development of vitiligo, and also to consider the advisability of their use in the treatment of patients with vitiligo.

A literary review of the PubMed, Cochrane Library, CyberLeninka, Clinicaltrial.gov and the Internet databases was conducted to study the role of specific microelements and vitamins involved in metabolic processes in the development of vitiligo disease.

Based on literature data, we can conclude that vitiligo by etiopathogenesis refers to multifactorial skin diseases, the final consequences of which is the cessation melanogenesis in certain areas of the skin. In all situations, one of the main factors is a metabolic disorder associated with the endoecology of the body. Vitamins and micronutrients play an important role in the pathogenetic chain of vitiligo. Thus, the introduction of individual micronutrients and vitamins into complex therapy of vitiligo seems extremely relevant and promising.

Активный интерес исследований к теме витилиго обусловлен возросшей возможностью терапии данного дерматоза неизвестной этиологии и его высокой психоэмоциональной значимостью, касающейся не только определённой личности, но и влияющей на общество в целом. В обзоре рассматриваются роль витаминов и микроэлементов в патогенезе витилиго и возможные комплексные подходы к терапии с учётом этих элементов.

Цель литературного обзора баз данных PubMed, Cochrane Library, CyberLeninka, Clinicaltrial.gov и сети Интернет по изучению роли конкретных микроэлементов и витаминов, принимающих участие в обменных процессах при развитии витилиго, ― оценить влияние витаминов и микроэлементов на течение и развитие заболевания, а также рассмотреть целесообразность применения их в терапии больных.

На основании данных литературы можно заключить, что витилиго по этиопатогенезу относится к мультифакториальным заболеваниям кожи, конечным последствием которых является прекращение меланогенеза в определённых участках кожи. Во всех ситуациях одним из основных факторов является нарушение обмена веществ, связанного с эндоэкологией организма. Немаловажную роль в патогенетической цепочке витилиго отводится витаминам и микроэлементам. Таким образом, представляется крайне актуальным и перспективным внедрение в комплексную терапию витилиго отдельных микроэлементов и витаминов.

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