Vol 14, No 6 (2011)

A case of Kaposhi's sarcoma and T-cell lymphoma in one patient is presented, successfully treated with extracorporal photochemotherapy.

Necrotizing vasculitis (NV) as disease if immune complexes presents a multisystem disorder of skin and mucous membranes, which often affects other organs and systems. Usually NV manifests after infectious diseases, external influences (hypothermia) or medicines intake. Clinical symptoms are diverse and depend on type, diameter and localization of affected vessels, as well as on severity of concomitant inflammatory processes. A case of NV affecting kidneys in a 15 y.o. girl developed after hypothermia. Diagnosis was confirmed by histology and immunohistochemical staining. Detection of immune complexes (IgG, С3-component of complement) and fibrinogen/fibrin in walls of dermal vessel was a weighty argument for treatment with korticosteriods. This case illustrates the necessity of timely diagnosis and prescription of adequate therapy.

A case of overlap-syndrome in a 39 years old patient is presented, which included lupus erytematosus and lichen ruber planus.

Authors present the results of studies of lipid metabolism disorders in patients with psoriatic arthritis in Ust-Ordynsky Buruatsky region. Results of the study have shown that dislipidemy (mostly IIb and IV types according to Frideriksen) was observed in 60% of patients, that is much less often than in european population. Differentiated approach to a treatment of psoriatic arthritis depending on detected lipid metabolism disorders.

Literature review is presented demonstrating a grave risk of pesticides spread for human health. In a case of skin contact severe disorders develop in a form of toxic and allergic response involving gastrointestinal tract, causing immunodeficiency, stimulating proinflammatory cytokines, development of embryotoxic and mutagenic effects, responsible for malignancies.

Current data are presented concerning etiology, pathogenesis, classification, clinical presentation, diagnosis and treatment of secondary erythroderma. Taking into account the difficulties of differential diagnosis and fundamental differences in therapeutic approaches authors underline the problem of diagnosis confirmation in secondary erythroderma, developing as complication of benign dermatoses.

For the first time authors conducted a complex assessment of age-related morphological and functional peculiarities of skin of different anatomic areas. Study sample included 43 healthy volunteers 4 to 74 years old. Structural parameters of skin were assessed using optic cogerent tomography equipped with removable flexible sonde with microscanner with longitudinal and transverse resolution 20 µm engineered and produced in Institute of applied physics RAS (Nizhniy Novgorod).