Vol 17, No 5 (2014)

Articles
Invasive capacity and proliferative activity of cutaneous melanoma and the epigenetic factor
Aksenenko M.B., Ruksha T.G.
Abstract
The invasive capacity and proliferative activity of the tumor are evaluated by immunohistochemical measurement of N-cadherin and Ki-67 expression in patients with cutaneous melanoma with and without BRAF oncogene V600E mutation. The B-Raf is a serine/threonine kinase involved in the Ras-Raf-MEK-MAPK signal pathway. This signal cascade normally regulates the cell proliferation andfunctioning, controlled by growth factors and hormones. The BRAF gene mutation is detected in 40-60% melanomas, predominantly in the tumors located in the closed parts of the body. The expression of N-cadherin is liable to increase in BRAF+ patients, this, in turn, presumably indicating more marked invasive characteristics of tumors in this patient population. The expression of Ki-67 virtually does not differ in patients with different BRAF status (p>0.05), this indicating no differences in the proliferative activity in these patients.
Russian Journal of Skin and Venereal Diseases. 2014;17(5):4-8
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Cyclosporine A in dermatology
Garanyan L.G., Avagyan D.V.
Abstract
Published data on cyclosporine A mechanism of action, treatment protocols, side effects, and combinations with other drugs are reviewed. Clinical data on the efficiency of the immunosuppressant, used in modern practical dermatology for therapy ofpsoriasis, atopic dermatitis, pemphigus vulgaris, alopecia areata, etc., are presented. Published data indicate high efficiency of cyclosporine A in the treatment of these diseases. Positive effects of the drug on the involved skin and induction of clinical remission in response to treatment are described.
Russian Journal of Skin and Venereal Diseases. 2014;17(5):8-16
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Bullous pemphigoid of pregnancy
Olisova O.Y., Snarskaya E.S., Vladimirov V.V., Plieva L.R., Dzybova E.M.
Abstract
Two patients sufferingfrom gestation bullous pemphigoid are described of pregnancy and the relevant publications are reviewed. The pathogenesis, clinical picture, histology, andtherapy are described. Importantly that the disease can be detected by the immunohistochemical study.
Russian Journal of Skin and Venereal Diseases. 2014;17(5):17-21
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Unilateral dermatoses: Relationship with Blashko's lines and neurological changes
Olisova O.Y., Grabovskaya O.V., Teplyuk N.P., Belousova T.A., Varshavsky V.A., Arsentyev N.S., Shpitalnikova N.G., Dzhavakhishvili I.S., Pyatilova P.M.
Abstract
Blashko’s lines correspond to the mutant cell migration and proliferation routes during embryogenesis. Unilateral dermatoses (UD), congenital and acquired ones, are located along Blashko’s lines. The term UD is more often used in Russian publications. Segmented, linear, blashkoid, or Blashko line dermatoses are the terms used by foreign specialists. The skin mosaicism theory is now confirmed at the cell level for at least 15 dermatoses, including nevoid andX-linked dermatoses. However, the pathogenetic mechanism of unilateral location inacquired UD remains unclear. Monolateral involvement may be observed in type I segmented mosaicism in autosomal dominant diseases. On the other hand, some authors explain the unilateral location of these dermatoses by involvement of the central and peripheral nervous system.
Russian Journal of Skin and Venereal Diseases. 2014;17(5):22-29
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Colloid milium
Ivanova I.N., Serdyukova E.A., Chuchunova T.K.
Abstract
A rare dermatosis - colloid milium - is described. Modern data on the etiology and pathogenesis, clinical picture, histology, and efficiency of modern therapies are presented. A case with colloid milium is described: a woman aged 60 years developed the dermatosis under conditions of insolation.
Russian Journal of Skin and Venereal Diseases. 2014;17(5):29-31
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Pulsed mesotherapy of immunoassociated dermatoses
Zavadsky V.N.
Abstract
Immunomodulating pulsed mesotherapy (IPMT) is described. Suspension of a long acting glucocorticoid (betamethsone, 7 mg/month, or triamcinolol, 40 mg/month) is diluted in saline and injected intracutaneously into the foci once a month. This treatment is effective in immunoassociated chronic dermatoses - atopic dermatitis, eczema, psoriasis, chronic urticaria in adults, adolescents, and children. This treatment is a convenient alternative to topical corticosteroids; in nonsevere dermatoses dermatoses it is a sufficient pathogenetic therapy. The advantages of IPMT are a convenient protocol - injections just once a month; the effect manifests from the very first days and is stable, relapses are becoming more and more rare and less severe; the total glucocorticoid dose in IPMT is even less than in topical corticosteroid therapy; the treatment is safe due to permissible fixed dose of the drug and its reliable natural reduction. The quality of life improves, the patient no longer depends on the use of ointments, the procedures are rare and easily tolerated; temporary disability is shorter, no hospitalization is needed.
Russian Journal of Skin and Venereal Diseases. 2014;17(5):31-35
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Dysproteinemia: A factor of psoriasis pathogenesis
Degtyarev O.V., Mesnyankina O.A.
Abstract
Disorders in the metabolic processes now attract special attention of scientists studying the pathogenesis of psoriasis. Total systems inflammation, emerging in psoriatic disease, stimulates the immunological changes and metabolic disorders, which aggravateandprolong the course of psoriasis and lead to the development of concomitant diseases. The paper presents a modern view on the problem of psoriasis development via dysmetabolic processes with emphasis on the role of protein metabolism disorders in the pathogenesis.
Russian Journal of Skin and Venereal Diseases. 2014;17(5):36-39
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Modern aspects of topical therapy in vitiligo
Sharafutdinova L.A., Lomonosov K.M.
Abstract
Modern topical drug therapies in vitiligo are discussed, with due consideration for the size and location of depigmented foci, activity of the process, clinical variety, presence of concomitant diseases, and age. The most rational modern drugs are topical corticosteroids, topical immunomodulators, topical antioxidants, calcipotriol, liposomal preparation, and prostaglandin E, each of them focused on several pathologically modified components in vitiligo. Intralesional drug injections are maximally effective and promote the onset of a rapid lasting effect with lesser probability of systemic side effects.
Russian Journal of Skin and Venereal Diseases. 2014;17(5):40-45
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Combined therapy of patients with psoriasis
Degtyarev O.V., Dumchenko V.V., Tkachenko T.A., Zhizhimova O.V., Bakhmutova E.G., Selivanova I.N., Erina I.A.
Abstract
A total of 72 patients with medium severe and severe psoriasis were hospitalized at Departmemnt for Skin Diseases of Astrakhan Regional Center for Skin and Sexually-Transmitted Diseases. The patients were distrubuted into 2 groups. Group 1 (N=42; 58.3%) patients received combined prednisolone and thymodepressin therapy. Group 2 patients (N=30; 41.6%) received thymodepressin monotherapy. Clinical recovery of psoriasis patients in group 1 was attained in 18 (42.8%), significant improvement in 15 (31.6%), and improvement in 7 (13.3%) patients. In group 2 clinical recovery was attained in 10 (33.3%), significant improvement in 12 (40%), and improvement in 8 (26.6%) patients. Hence, clinical recovery in the two groups was attained in 28 (38.8%), significant improvement in 27 (37.5%), and improvement in 15 (20.8%) patients. The results indicated that combined therapy led to more rapid and complete resolution of skin manifestations than thymodepressin monotherapy.
Russian Journal of Skin and Venereal Diseases. 2014;17(5):46-50
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Modern aspects of effective therapy acne vulgaris
Perlamutrov Y.N., Olkhovskaya K.B.
Abstract
Today the diagnosis of acne severity is not limited by evaluation of clinical manifestations only. Therefore, indications for isotretinoin therapy of the dermatosis have been extended. We evaluated the efficiency and safety of Sotret in therapy of 30 patients with severe acne and with acne resistant to other therapies. Of these, 19 patients (63.33%) presented with mild-severety and 11 (36.67%) with severe condition. The acne dermatological index (ADI) and CADI score were evaluated and biochemical and clinical blood analyses were carried out in all patients. Sotret monotherapy was carried out. The clinical remission was attained in 28 (93.33%), and slight amelioration in 2 (6.67%) patients. Sotret therapy proved to be highly effective and was well tolerated.
Russian Journal of Skin and Venereal Diseases. 2014;17(5):51-54
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Photodynamic therapy for acne vulgaris
Vladimirov V.V., Olisova O.Y., Vertieva E.Y., Goryachkina M.V., Smirnov K.V.
Abstract
Acne vulgaris remain the most prevalent disease in adolescents and young adults. Today photo therapy, specially, photodynamic therapy, is usedfor the treatment of acne. The mechanism of action of this treatment modality is based on selective destruction of cells as a result of photo-stimulated chemical reaction. Twenty patients with acne of moderate severity were treated by photodynamic therapy in combination with systemic antibacterial therapy (doxicyclin) and topical drugs (azelaic acid). Stable improvement of the skin process was attained in 86% patients. Hence, photodynamic therapy proved to be a safe and effective methodfor the treatment of acne.
Russian Journal of Skin and Venereal Diseases. 2014;17(5):54-58
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Role of sexually transmitted infections in the development of female infertility. Therapeutic and preventive strategies
Unanyan A.L., Snarskaya E.S., Lomonosov K.M.
Abstract
Sexually transmitted infections (STI) often become the cause of organic obstruction of the uterine tubes. Multicomponent mechanisms of sterility formation in young women under conditions of inflammatory diseases of the pelvic organs, detected in 60--65% women of reproductive age, are described. The spectrum of genital infections, detected by PCR analysis of discharge from the cervical canal and uterine cavity from women with chronic endometritis, includes chlamydiasis (in 14.9% patients), genital herpes (33.6%), ureaplasmosis (37.8%), mycoplasmosis (11.6%), and cytomegalovirus infection (18.9%). Today the clinical picture of many STD is blurred, and the main clinical sign of a chronic disease in young women is often disordered reproductive function, presented by sterility, including failure of repeated extracorporeal fertilization. Addition of longidase to combined therapy for sterility of different origin led to good results.
Russian Journal of Skin and Venereal Diseases. 2014;17(5):59-62
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A nodule in the left arm
Tarasenko G.N., Utkin P.S., Kirienko T.V., Khimushkina E.V., Grebenyuk D.V.
Russian Journal of Skin and Venereal Diseases. 2014;17(5):63-64
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