Efficiency of appliance of cranial electrotherapy stimulation and fabomotizole medication as part of combination therapy of patients with lichen ruber planus

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access


BACKGROUND: Taking into consideration importance of a stress factor in the pathogenesis of lichen ruber planus, it seems reasonable and promising to include safe and effective methods for its correction in the therapy of such patients.

AIMS: To evaluate efficiency of the combination therapy in patients with lichen ruber planus with inclusion of cranial electrotherapy stimulation and fabomotizole medication.

MATERIALS AND METHODS: The object of the study included 65 patients (42 women ― 64.6% and 23 men ― 35.4% at the ages from 18 to 75 (43.8±15.3 years) with a common typical form of lichen ruber planus. Duration of the disease ranged from 1 to 42 months (13.3±11.6 months). Two groups were formed by the method of adaptive randomization. In the main group (n=33), patients received chloroquine of 250 mg orally twice a day, topical glucocorticosteroids and additionally cranial electrotherapy stimulation. In the comparison group (n=32), the similar therapy was carried out, but instead of cranial electrotherapy stimulation, fabomotizole of 10 mg was prescribed orally 3 times a day after meals. The course of hospital treatment in both groups was 21 days, the follow-up was 12 weeks. Results of the therapy were assessed on the 7; 14 and 21st days. The examination algorithm included: assessment of clinical manifestations taking into account the Index Lichen Planus; the impact of pruritus on the daily life of patients with the help of the generally accepted Behavioral rating scores questionnaire; study of the psychoemotional state of patients using the Dermatology Life Quality Index, Hamilton Anxiety Scale and Hamilton Depression Rating Scale.

RESULTS: Before prescription of the therapy in both groups, there were no statistically significant differences (p >0.001) in the studied indices, scales, and questionnaire. After the combination therapy in association with cranial electrotherapy stimulation in patients of the main group, starting from the 7th day of the therapy, significantly more favorable results were achieved in terms of the studied parameters (Index Lichen Planus, Dermatology Life Quality Index, Hamilton Anxiety Scale and Hamilton Depression Rating Scale). As for the effect of pruritus on the daily activities of patients (Behavioral rating scores questionnaire), in both groups there was its equally statistically significant (p <0.001) decrease. Patients of the main group and the comparison group tolerated the treatment well, there were no side effects.

CONCLUSIONS: In the main group, using cranial electrotherapy stimulation, normalization of indicators reflecting the activity of the skin pathological process, psychoemotional state and dermatology life quality was statistically significant and took place within a shorter period of time.

Full Text

Restricted Access

About the authors

Marina M. Tlish

Kuban State Medical University

Email: tlish_mm@mail.ru
ORCID iD: 0000-0001-9323-4604
SPIN-code: 8452-4062

MD, Dr. Sci. (Med.), Professor

Russian Federation, 4, Sedina Street, Krasnodar, 350063

Polina S. Osmolovskaya

Kuban State Medical University

Author for correspondence.
Email: polina_osmolovskaya@mail.ru
ORCID iD: 0000-0002-6764-0796
SPIN-code: 1358-3426

MD, Assistant Lecturer

Russian Federation, 4, Sedina Street, Krasnodar, 350063


  1. Marquez LK, Santos LR, da Silva NC, et al. Oral lichen planus associated with lichen pigmentosa and lichen sclerosus in monozygotic twins. Am J Dermatopathol. 2021;43(5):368–372. doi: 10.1097/DAD.00000000000001847
  2. Molochkova YV, Molochkov VA, Grineva NK. Frequency and features of various forms of lichen planus in the Moscow region. Almanac Clin Med. 2018;46(1):82–87. (In Russ). doi: 10.18786/2072-0505-2018-46-1-82-87
  3. Georgescu SR, Mitran CI, Mitran MI, et al. Oxidative stress in cutaneous lichen planus ― a narrative review. J Clin Med. 2021;10(12):2692. doi: 10.3390/jcm10122692
  4. Gorouhi F, Davari P, Fazel N. Cutaneous and mucosal lichen planus: a comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis. Sci World J. 2014;2014:742826. doi: 10.1155/2014/742826
  5. Sawant NS, Vanjari NA, Khopkar U, et al. A study of depression and quality of life in patients of lichen planus. Sci World J. 2015;2015:817481. doi: 10.1155/2015/817481
  6. Kubanov AA, Perlamutrov YU, Olisova OY, et al. Federal clinical guidelines. RODVK. LP 2020. (In Russ). Available from: https://www.rodv.ru/klinicheskie-rekomendacii/. Дата обращения: Accessed: 15.03.2021.
  7. Anisimova IV, Simonyan LA. The frequency of the combination of lichen planus with somatic pathology and local adverse factors of the oral cavity. Problems Dentistry. 2019;15(1):16–22. (In Russ). doi: 10.18481/2077-7566-2018-15-1-16-22
  8. Mansur AT, Kilic Z, Atalay F. Psychological evaluation of patients with cutaneous lichen planus. Dermatol Psychosomatics. 2004;5(3):132–136. doi: 10.1159/000081157
  9. Jalenques I, Lauron S, Almon S, et al. Prevalence and odds of signs of depression and anxiety in patients with lichen planus: systematic review and meta-analyses. Acta Derm Venereol. 2020;100(18):00330. doi: 10.2340/00015555-3660
  10. Dorozhenok IY, Matyushenko EN, Olisova OY. Dysmorphophobia in dermatological practice. Russian Journal of Skin and Venereal Diseases. 2014;17(1):42–47. (In Russ).
  11. Lundqvist EN, Wahlin YB, Bergdahl M, et al. Psychological health in patients with genital and oral erosive lichen planus. JEADV. 2006;20(6):661–666. doi: 10.1111/j.1468-3083.2006.01559x
  12. Hiremutt DR, Mhapuskar AA, Singh P, et al. Comparison of anxiety and depression scores in patients with oral lichen planus and normal individuals. J Int Clin Dent Res Organ. 2020;12:140–147. doi: 10.4103/jicdro.jicdro_42_19
  13. Lukinyh LM, Tiunova NV. Lichen planus of the oral mucosa (etiology, pathogenesis, clinical picture, modern methods of treatment). Nizhny Novgorod: NGMA; 2013. 116 р. (In Russ).
  14. Pshennikova MG. The phenomenon of stress. Emotional stress and its role in pathology (lecture 5). In: Actual problems of pathophysiology (selected lectures). Ed. by B.B. Morozov. Moscow: Medicine; 2001. Р. 220–253. (In Russ).
  15. Lebedev VP. Transcranial electrical stimulation. Experimental clinical research. Vol. 3. Saint Petersburg; 2009. 392 р. (In Russ).
  16. Savchenko ES, Nazarov RN, Apchel AV, et al. Correction of psychovegetative disorders in the process of complex treatment of patients with chronic dermatoses. Bulletin of the Russian Military Medical Academy. 2012;3(39):107–110. (In Russ).
  17. Sizova VY, Volchanskiy EI. Vegetative and vascular changes in children with atopic dermatitis against the background of the use of transcranial electrical stimulation. Volgograd Med Sci J. 2011;(1):25–28. (In Russ).
  18. Silina LV, Yacun SM. The use of transcranial electrical stimulation in the complex therapy of acne. Palliative Med Rehabilitat. 2009;(1):30–32. (In Russ).
  19. Barkova SV. The effectiveness of the use of transcranial electrical stimulation in order to correct the psychophysiological status of patients with lichen planus of the oral mucosa. Bulletin VolGMU. 2007;(1):35–37. (In Russ).
  20. Tashiro M, Horikawa E, Mochizuki H, et al. Effects of fexofenadine and hydroxyzine on brake reaction time during car-driving with cellular phone use. Hum Psychopharmacol Clin Exp. 2005;20(7)501–509. doi: 10.1002/hup.713
  21. Orriols L, Luxcey A, Contrand B, et al. Road traffic crash risk associated with prescription of hydroxyzine and other sedating H1-antihistamines: a responsibility and case-crossover study. Accid Anal Prev. 2017;106:115–121. doi: 10.1016/j.aap.2017.05.030
  22. Kotova OV. Treatment of generalized anxiety disorder: approaches to treatment. Rational Pharmacotherapy. 2012;(1):87–91. (In Russ).
  23. Bekker RA, Bykov YU. Afobazol (fabomatizol): anxiolytic, and not only (Israeli-Russian view of the problem). Psychiatry Psychopharmacotherapy named after P.B. Gannushkin. 2017;19(4):12–21. (In Russ).
  24. Manolache L, Seceleanu-Petrescu D, Benea V. Lichen planus patients and stressful events. JEADV. 2008;22(4):437–441. doi: 10.1111/j.1468-3083.2007. 02458.x
  25. Hajretdinova KF, Yusupova LA. Comorbid anxiety and depressive disorders in patients with lichen planus, taking into account gender differences. Therapist. 2016;(11):34. (In Russ).
  26. López-Jornet P, Camacho-Alonso F. Quality of life in patients with oral lichen planus. J Eval Clin Pract. 2010;16(1):111–113. doi: 10.1111/j.1365-2753.2009. 01124.x

Supplementary files

There are no supplementary files to display.

Copyright (c) 2022 Eco-Vector

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies