Genetic determinants of atopic dermatitis

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Abstract

Atopic dermatitis is a heterogeneous disease, the pathogenesis of which is associated with mutations of genes encoding structural proteins of the epidermis, barrier enzymes and their inhibitors.

The article analyzes data from the works of various authors on the study of gene expression in atopic dermatitis, and notes the role of genes regulating innate and adaptive immune responses, as well as environmental factors inducing the disease. Recent studies indicate a key role of epigenetic changes in the development of the disease. Epigenetic modifications are mainly mediated by DNA methylation, histone acetylation and the action of specific non-coding RNAs. It has been documented that the profile of epigenetic changes in patients with atopic dermatitis differs from that observed in healthy individuals.

Understanding epigenetic changes is critical for developing personalized treatment strategies.

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About the authors

Inna P. Grebennikova

Saratov State Medical University named after V.I. Razumovsky

Author for correspondence.
Email: inna.pavlovna.gr@mail.ru
ORCID iD: 0009-0003-8951-1244
SPIN-code: 4615-2340
Russian Federation, 22 Proviantskaya street, 410028 Saratov

Anna V. Morrison

Saratov State Medical University named after V.I. Razumovsky

Email: morrison-av@rambler.ru
ORCID iD: 0000-0001-7214-3156
SPIN-code: 3018-8421

MD, Cand. Sci. (Med.), Associated Professor

Russian Federation, 22 Proviantskaya street, 410028 Saratov

Tatiana E. Lipatova

Saratov State Medical University named after V.I. Razumovsky

Email: lipatova.t@inbox.ru
ORCID iD: 0000-0002-7401-9930
SPIN-code: 2483-3578

MD, Dr. Sci. (Med.), Professor

Russian Federation, 22 Proviantskaya street, 410028 Saratov

Maria G. Yeremina

Saratov State Medical University named after V.I. Razumovsky

Email: 913693@mail.ru
ORCID iD: 0000-0001-9752-1352
SPIN-code: 9205-0670

MD, Dr. Sci. (Med.), Associated Professor

Russian Federation, 22 Proviantskaya street, 410028 Saratov

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