Possibilities of skin ultrasound examination in the management of patients with localized scleroderma
- Authors: Krakhaleva Y.A.1, Kolerova A.V.1, Sorokina E.D.1, Mikailova D.A.1, Krinitsyna Y.M.1,2, Filimonov P.N.3, Sergeeva I.G.1
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Affiliations:
- Novosibirsk State University
- Federal Research Center of Fundamental and Translational Medicine
- Novosibirsk Tuberculosis Research Institute
- Issue: Vol 24, No 1 (2021)
- Pages: 17-24
- Section: CLINICAL PICTURE, DIAGNOSIS, AND THERAPY OF DERMATOSES
- URL: https://rjsvd.com/1560-9588/article/view/57058
- DOI: https://doi.org/10.17816/dv57058
- ID: 57058
Cite item
Abstract
With the help of ultrasound examination (ultrasound), it is possible to visualize the skin of patients with suspected localized scleroderma, as well as to objectively determine the stage of the disease and assess the effectiveness of therapy.
Three patients with linear, plaque forms of scleroderma, as well as lichen sclerosus, underwent skin ultrasound using a Skinscanner DUB TPM device with a 75 MHz transducer, 4 mm penetration, 21 μm resolution in the area of lesions and in adjacent areas of healthy skin, using their ratio coefficient (RC) for comparative evaluation. The thickness of the epidermis and dermis, their echogenicity were determined.
With a linear form of scleroderma, an increase in the thickness of the epidermis in the area of the focus (RC 0.85±0.0125) and a decrease in its echogenicity (RC 1.58±0.46) were observed. The echogenicity of the dermis was significantly reduced in the lesion (RC 3.02±1.17). The dermis thickness was slightly less in the center of the lesion (RC 1.09), at the periphery of the lesion it was moderately increased (RC 0.86). In the plaque form of scleroderma, a decrease in the echogenicity of the epidermis was observed in the foci (RC 1.32±0.49); an increase in the thickness of the dermis (RC 0.79±0.16) and a decrease in its e echogenicity (RC 1.26±0.57). In 7 of 11 foci, a subepidermal hypoechoic band was visualized. With lichen sclerosis in the foci, an increase in the thickness of the epidermis (RC 0.42±0.12) and its acoustic density (RC 0.63±0.0793), a decrease in the thickness and echo density of the dermis (RC 1.32±0.00943 and RC 1.55±0.6, respectively).
With different forms of LS, a different ultrasound picture was observed, depending on the stage and activity of the process. The changes identified during treatment reflect the effectiveness of the therapy and the rate of restoration of the skin structure during therapy.
Full Text
About the authors
Yulia A. Krakhaleva
Novosibirsk State University
Author for correspondence.
Email: goodjulia1993@mail.ru
ORCID iD: 0000-0001-6409-4956
MD
Russian Federation, 630090, Novosibirsk, Pirogova St., 2Anastasia V. Kolerova
Novosibirsk State University
Email: periosteum@mail.ru
ORCID iD: 0000-0003-0688-6175
Assistant
Russian Federation, 630090, Novosibirsk, Pirogova St., 2Elena D. Sorokina
Novosibirsk State University
Email: afonnikovadoc@gmail.com
ORCID iD: 0000-0002-7965-9881
Рrofessor
Russian Federation, 630090, Novosibirsk, Pirogova St., 2Daria A. Mikailova
Novosibirsk State University
Email: mika20-04@mail.ru
ORCID iD: 0000-0001-5630-0801
Рrofessor
Russian Federation, 630090, Novosibirsk, Pirogova St., 2Yulia M. Krinitsyna
Novosibirsk State University; Federal Research Center of Fundamental and Translational Medicine
Email: julia407@yandex.ru
ORCID iD: 0000-0002-9383-0745
SPIN-code: 5925-9031
Dr. Sci. (Med.), Professor
Russian Federation, 630090, Novosibirsk, Pirogova St., 2Pavel N. Filimonov
Novosibirsk Tuberculosis Research Institute
Email: pfilimonov@yandex.ru
ORCID iD: 0000-0002-5786-9319
SPIN-code: 5550-0923
Dr. Sci. (Med.)
Russian Federation, 630090, Novosibirsk, Pirogova St., 2Irina G. Sergeeva
Novosibirsk State University
Email: i_g_sergeeva@mail.ru
ORCID iD: 0000-0003-1748-8957
SPIN-code: 4766-0410
Dr. Sci. (Med.), Professor
Russian Federation, 630090, Novosibirsk, Pirogova St., 2References
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