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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Skin and Venereal Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Skin and Venereal Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский журнал кожных и венерических болезней</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1560-9588</issn><issn publication-format="electronic">2412-9097</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">57058</article-id><article-id pub-id-type="doi">10.17816/dv57058</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL PICTURE, DIAGNOSIS, AND THERAPY OF DERMATOSES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИКА, ДИАГНОСТИКА И ЛЕЧЕНИЕ ДЕРМАТОЗОВ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Possibilities of skin ultrasound examination in the management of patients with localized scleroderma</article-title><trans-title-group xml:lang="ru"><trans-title>Возможности ультразвукового исследования кожи в ведении пациентов с локализованной склеродермией</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6409-4956</contrib-id><name-alternatives><name xml:lang="en"><surname>Krakhaleva</surname><given-names>Yulia A.</given-names></name><name xml:lang="ru"><surname>Крахалева</surname><given-names>Юлия Андреевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD</p></bio><email>goodjulia1993@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0688-6175</contrib-id><name-alternatives><name xml:lang="en"><surname>Kolerova</surname><given-names>Anastasia V.</given-names></name><name xml:lang="ru"><surname>Колерова</surname><given-names>Анастасия Викторовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Assistant </p></bio><bio xml:lang="ru"><p>ассистент </p></bio><email>periosteum@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7965-9881</contrib-id><name-alternatives><name xml:lang="en"><surname>Sorokina</surname><given-names>Elena D.</given-names></name><name xml:lang="ru"><surname>Сорокина</surname><given-names>Елена Дмитриевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Рrofessor</p></bio><bio xml:lang="ru"><p>ассистент </p></bio><email>afonnikovadoc@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5630-0801</contrib-id><name-alternatives><name xml:lang="en"><surname>Mikailova</surname><given-names>Daria A.</given-names></name><name xml:lang="ru"><surname>Микаилова</surname><given-names>Дарья Амирах Кызы</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Рrofessor</p></bio><bio xml:lang="ru"><p>ассистент</p></bio><email>mika20-04@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9383-0745</contrib-id><contrib-id contrib-id-type="spin">5925-9031</contrib-id><name-alternatives><name xml:lang="en"><surname>Krinitsyna</surname><given-names>Yulia M.</given-names></name><name xml:lang="ru"><surname>Криницына</surname><given-names>Юлия Михайловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>julia407@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5786-9319</contrib-id><contrib-id contrib-id-type="spin">5550-0923</contrib-id><name-alternatives><name xml:lang="en"><surname>Filimonov</surname><given-names>Pavel N.</given-names></name><name xml:lang="ru"><surname>Филимонов</surname><given-names>Павел Николаевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>д.м.н</p></bio><email>pfilimonov@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1748-8957</contrib-id><contrib-id contrib-id-type="spin">4766-0410</contrib-id><name-alternatives><name xml:lang="en"><surname>Sergeeva</surname><given-names>Irina G.</given-names></name><name xml:lang="ru"><surname>Сергеева</surname><given-names>Ирина Геннадьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>i_g_sergeeva@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Novosibirsk State University</institution></aff><aff><institution xml:lang="ru">Новосибирский национальный исследовательский государственный университет</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Federal Research Center of Fundamental and Translational Medicine</institution></aff><aff><institution xml:lang="ru">Федеральный исследовательский центр фундаментальной и трансляционной медицины</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Novosibirsk Tuberculosis Research Institute</institution></aff><aff><institution xml:lang="ru">Новосибирский научно-исследовательский институт туберкулёза</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2021</year></pub-date><volume>24</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>17</fpage><lpage>24</lpage><history><date date-type="received" iso-8601-date="2021-01-05"><day>05</day><month>01</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-03-22"><day>22</day><month>03</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, ООО "Эко-Вектор"</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2025-08-01"/></permissions><self-uri xlink:href="https://rjsvd.com/1560-9588/article/view/57058">https://rjsvd.com/1560-9588/article/view/57058</self-uri><abstract xml:lang="en"><p>With the help of ultrasound examination (ultrasound), it is possible to visualize the skin of patients with suspected localized scleroderma, as well as to objectively determine the stage of the disease and assess the effectiveness of therapy.</p> <p>Three patients with linear, plaque forms of scleroderma, as well as lichen sclerosus, underwent skin ultrasound using a Skinscanner DUB TPM device with a 75 MHz transducer, 4 mm penetration, 21 μm resolution in the area of lesions and in adjacent areas of healthy skin, using their ratio coefficient (RC) for comparative evaluation. The thickness of the epidermis and dermis, their echogenicity were determined.</p> <p>With a linear form of scleroderma, an increase in the thickness of the epidermis in the area of the focus (RC 0.85±0.0125) and a decrease in its echogenicity (RC 1.58±0.46) were observed. The echogenicity of the dermis was significantly reduced in the lesion (RC 3.02±1.17). The dermis thickness was slightly less in the center of the lesion (RC 1.09), at the periphery of the lesion it was moderately increased (RC 0.86). In the plaque form of scleroderma, a decrease in the echogenicity of the epidermis was observed in the foci (RC 1.32±0.49); an increase in the thickness of the dermis (RC 0.79±0.16) and a decrease in its e echogenicity (RC 1.26±0.57). In 7 of 11 foci, a subepidermal hypoechoic band was visualized. With lichen sclerosis in the foci, an increase in the thickness of the epidermis (RC 0.42±0.12) and its acoustic density (RC 0.63±0.0793), a decrease in the thickness and echo density of the dermis (RC 1.32±0.00943 and RC 1.55±0.6, respectively).</p> <p>With different forms of LS, a different ultrasound picture was observed, depending on the stage and activity of the process. The changes identified during treatment reflect the effectiveness of the therapy and the rate of restoration of the skin structure during therapy.</p></abstract><trans-abstract xml:lang="ru"><p>При помощи ультразвукового исследования (УЗИ) возможны визуализация кожи пациентов с подозрением на локализованную склеродермию, а также объективное определение стадии заболевания и оценка эффективности терапии.</p> <p>Трём пациентам с линейной и бляшечной формой склеродермии, а также со склероатрофическим лихеном проводили УЗИ кожи на аппарате Skinscanner DUB TPM датчиком с частотой 75 МГц, пенетрацией 4 мм, разрешающей способностью 21 мкм в области очагов поражения и в прилегающих участках здоровой кожи, используя для сравнительной оценки их коэффициент соотношения (КС). Определяли толщину эпидермиса и дермы, их эхогенность.</p> <p>При линейной форме склеродермии наблюдали увеличение толщины эпидермиса в области очага (КС 0,85±0,0125), снижение его эхоплотности (КС 1,58±0,46). Эхогенность дермы была значительно снижена в очаге поражения (КС 3,02±1,17). Толщина дермы была незначительно меньше в центре очага (КС 1,09), на периферии очага ― умеренно увеличена (КС 0,86). При бляшечной форме склеродермии в очагах наблюдали снижение эхоплотности эпидермиса (КС 1,32±0,49), увеличение толщины дермы (КС 0,79±0,16) и снижение её эхоплотности (КС 1,26±0,57). В 7 из 11 очагов визуализировали субэпидермальную гипоэхогенную полосу. При склероатрофическом лихене в очагах наблюдали увеличение толщины эпидермиса (КС 0,42±0,12) и его акустической плотности (КС 0,63±0,0793), снижение толщины и эхоплотности дермы (КС 1,32±0,00943 и 1,55±0,6 соответственно).</p> <p>При различных формах локализованной склеродермии наблюдается разная УЗ-картина, зависящая от стадии и активности процесса. Изменения, выявленные в процессе лечения, отражают эффективность проводимой терапии и темпы восстановлении структуры кожи на фоне терапии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>localized scleroderma</kwd><kwd>linear scleroderma “en coupe de sabre”</kwd><kwd>plaque scleroderma</kwd><kwd>lichen sclerosus</kwd><kwd>ultrasound examination of the skin</kwd><kwd>non-invasive diagnostic methods</kwd><kwd>clinical case</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>локализованная склеродермия</kwd><kwd>линейная склеродермия по типу удара саблей</kwd><kwd>бляшечная склеродермия</kwd><kwd>склероатрофический лихен</kwd><kwd>ультразвуковое исследование кожи</kwd><kwd>неинвазивные методы диагностики</kwd><kwd>клинический случай</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Federal clinical guidelines. Dermatovenerology-2015: Skin diseases. 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