Bacterial vaginosis: evaluation of the effectiveness of simultaneous treatment of sexual partners

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Abstract


BACKGROUND: Bacterial vaginosis (BV) is one of the most common diseases affecting women of reproductive age. The main problem of BV is the low efficiency of traditional methods of treatment with a frequent recurrence of up to 50%.

MATERIALS AND METHODS: A total of 59 patients were examined and treated with the diagnosis of BV, which was confirmed in accordance with the Amsel criteria. The main group included women with BV and their male partners, whereas the compared group included only women with BV. All women were treated with systemic metronidazole and topical clindamycin, and suppositories with lactic acid were prescribed at the second stage. The men partners were treated systemically with metronidazole and topically with clindamycin.

RESULTS: Gardnerella vaginalis, Atopobium vaginae, and Prevotella were the most commonly identified bacteria in the vaginal discharge. In men, BV-associated bacteria were found in the foreskin of the glans penis and distal urethra. The similarity of the microflora of the genital organs of women and their male partners was determined. In women with sexual partners who were treated 6 months after the therapy, the number of BV-associated bacteria was detected two or more times less frequently than in patients in the comparison group. For the men, the number of complaints and clinical symptoms significantly decreased after the treatment. Significant decreases in Gardnerella vaginalis, Atopobium vaginae, Prevotella spp., Leptotrichia amnionii, and Mobiluncus were achieved in the foreskin and Gardnerella in the urethra. In the main group of women, the frequency of BV recurrences recorded was 2.3 times less than that in the comparison group.

CONCLUSION: The treatment of partners of women with BV effectively reduces the growth of BV-associated bacteria and significantly decreases the frequency of recurrences.


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About the authors

V. A. Okhlopkov

The Institute of the Federal Scientific and Clinical Center for Resuscitation and Rehabilitation

Email: info@eco-vector.com
ORCID iD: 0000-0002-3515-6027

Russian Federation, Moscow

S. V. Barinov

FGBOU VO "Omsk State Medical University" of the Ministry of Health of Russia

Email: info@eco-vector.com
ORCID iD: 0000-0002-0357-7097

Russian Federation, Omsk

Yu. I. Tirskaya

FGBOU VO "Omsk State Medical University" of the Ministry of Health of Russia

Email: info@eco-vector.com
ORCID iD: 0000-0001-5365-7119

Russian Federation, Omsk

Turan Shakhin kyzy Babaeva

Perinatal Center BUZ Omsk Region "Regional Clinical Hospital"

Author for correspondence.
Email: babaeva.turan@mail.ru
ORCID iD: 0000-0002-9960-6197

Russian Federation, Omsk

L. B. Sinelnikova

Perinatal Center BUZ Omsk Region "Regional Clinical Hospital"

Email: info@eco-vector.com
ORCID iD: 0000-0002-5959-7636

Russian Federation, Omsk

T. V. Terletskaya

BUZ Omsk region "Clinical dermatovenerologic dispensary"

Email: info@eco-vector.com
ORCID iD: 0000-0001-5425-0847

Russian Federation, Omsk

References

  1. Kenyon C, Colebunders R, Crucitti T. The global epidemiology of bacterial vaginosis: a systematic review. Am J Obstet Gynecol. 2013;209(6):505-23.Kimberly A, Workowski KA. Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines. Clin Infect Dis. 2015;61(9):759-62.Prilepskaya VN, Mirzabalaeva AK, Kira EF, Gomberg MA, Apolikhina IA, Bairamova GR. Federal Clinical Guidelines. Diagnosis and treatment of diseases accompanied by pathological secretions from the genital tract of women. Moscow: Russian Society of Obstetricians and Gynecologists; 2013. (in Russian)Hilbert DW, Smith WL, Paulish-Miller TE, Chadwick SG, Toner G, Mordechai E, et al. Utilization of molecular methods to identify prognostic markers for recurrent bacterial vaginosis. Diagn Microbiol Infect Dis. 2016;86(2):231-42.Lopez-Torres L, Chiappe M, Carcamo C, Garnett G, Holmes K, Garcia P. Prevalence of bacterial vaginosis and associated factors in twenty peruvian cities. Rev Peru Med Exp Salud Publica. 2016;33(3):448-54.Zozaya M, Ferris MJ, Siren JD, Lillis R, Myers L, Nsuami MJ, et al. Bacterial communities in penile skin, male urethra, and vaginas of heterosexual couples with and without bacterial vaginosis. Microbiome. 2016;4:16. doi: 10.1186/s40168-016-0161-6Smart S, Singal A, Mindel A. Social and sexual risk factors for bacterial vaginosis. Sex Transm Jnfect. 2004;80(1):58-62.Allswort JE, Peipert JF. Severity of bacterial vaginosis and the risk of sexually transmitted infection. Am J Obstet Gynecol. 2011;205(2):113-6.Norris Turner A, Carr Reese P, Snead MC, Fields K, Ervin M, Kourtis AP, et al. Recent biomarker-confirmed unprotected vaginal sex, but not self-reported unprotected sex, is associated with recurrent bacterial vaginosis. Sex Transm Dis. 2016;43(3):172-6.Sanchez S, Garcia P, Thomas K, Catlin M, Holmes KK. Intravaginal metronidazole gel versus metronidazole plus nystatin ovules for bacterial vaginosis: a randomized controlled trial. Am J Obstet Gynec. 2004;191(6):1898-906.Manhart LE, Gillespie CW, Lowens MS, Khosropour СM, Colombara DV, Goldenet MR, et al. Standard treatment regimens for nongonococcal urethritis have similar but declining cure rates: a randomized controlled trial. Clin Infect Dis. 2013;56(7):934-42.Swidsinski A, Doerffel Y, Loening-Baucke V, Swidsinski S, Verstraelen H, Vaneechoutte M, et al. Gardnerella biofilm involves females and males and is transmitted sexually. Gynecol Obstet Invest. 2010;70(4):256-63.Nelson DE, Dong Q, Van der Pol B, Toh E, Fan B, Katz BP, et al. Bacterial communities of the coronal sulcus and distal urethra of adolescent males. PLoS One. 2012;7(5):e36298.Gottschick C, Deng ZL, Vital M, Masur C, Abels C, Pieper DH, Wagner-Dobler I. The urinary microbiota of men and women and its changes in women during bacterial vaginosis and antibiotic treatment. Microbiome. 2017;5(1):99.Vestraelen H. Bacterial vaginosis: a sexually enhanced disease. Int J STD AIDS. 2008;19(8):575-6.Plummer EL, Vodstrcil LA, Danielewski JA, Murray GL, Fairley CK, Garland SM, et al. Combined oral and topical antimicrobial therapy for male partners of women with bacterial vaginosis: Acceptability, tolerability and impact on the genital microbiota of couples – a pilot study. PLoS ONE. 2018;13(1):190-9.Mayorov MV, Zhuchenko SI, Chernyak OL. Bacterial vaginosis: practical aspects of etiology, diagnosis and treatment. Medical Aspects of Women’s Health. Ukrainian Journal. 2014;76(2):55-61. (in Russian) Available at: https://mazg.com.ua/uploads/issues/2014/2(76)/80101349.pdf Accessed 08 Dec 2020.Thomasson JL, Gelbard SM, Scaglione NJ. Bacterial vaginosis: current review with indications for asymptomatic therapy. Am. J. Obstet. Gynecol. 1991;165:1210-17.Vejtorp M, Bollerup AC, Vejtorp L, Fanoe E, Nathan E, Reiter A, et al. Bacterial vaginosis: a double – blind randomized trial of the effect of treatment of the sexual partner. Br J Obstet Gynecol. 1988;95(9):920-6.Clinical recommendations for the diagnosis and treatment of diseases accompanied by pathological discharge from the genital tract of women. Moscow: Russian Society of Obstetricians and Gynecologists; 2019. (in Russian)Lipova EV, Pakhomova AI. Controversial way of sexual transmission of bacterial vaginosis: pro et contra. Experience of local treatment with ascorbic acid preparation. Terra Medica. Russian Journal. 2015;(1):6-12. (in Russian)Liu CM, Hungate BA, Tobian AA, Serwadda D, Ravel J, Lester R, et al. Male circumcision significantly reduces prevalence and load of genital anaerobic bacteria. MBio. 2013;4(2):e00076. Available at: https://pubmed.ncbi.nlm.nih.gov/23592260/ Accessed 08 Dec 2020.Mandar R, Punab M, Borovkova N, Lapp E, Kiiker R, Korrovits P, et al. Complementary seminovaginal microbiome in couples. Res Microbiol. 2015;166(5):440-7.Weng SL, Chiu CM, Lin FM, Huang WC, Liang C, Yang T, et al. Bacterial communities in semen from men of infertile couples: metagenomic sequencing reveals relationships of seminal microbiota to semen quality. PLoS One. 2014;9(10):110-52.Tkachenko AG, Fedotova FV. Dependence of protective functions of Escherichia coli polyamines on strength of stress caused by superoxide radicals. Biochemistry (Moscow). 2007;72(1):109-16. (in Russian)Kungurov NV, Gerasimova NM, Gorbunov AP, Skidan NI, Shcherbakova NV, Evstigneeva NP, et al. Conditionally pathogenic microflora of the urogenital tract in men with inflammatory diseases of the urethra. Journal of Postgraduate Medical Education. Russian Journal. 2010;(2):26-32. (in Russian)Golshani M, Taheri S, Eslami G, Suleimani Rahbar AA, Fallah F, Goudarzi H. Genital tract infection in asymptomatic infertile men and its effect on semen quality. Iranian J Publ Health. 2006;35(3):81-4.Amaya-Guio J, Viveros-Carreno DA, Sierra-Barrios EM, Martinez-Velasquez MY, Grillo-Ardilaet GF. Antibiotic treatment for the sexual partners of women with bacterial vaginosis. Cochrane Database Syst Rev. 2016;10(10):CD011701. Available at: https://pubmed.ncbi.nlm.nih.gov/27696372/ Accessed 08 Dec 2020Nelson DE, Dong Q, Van der Pol B, Toh E, Fan B, Katz BP, et al. Bacterial communities of the coronal sulcus and distal urethra of adolescent males. PLoS One. 2012;7(5):362-98.Liu CM, Hungate BA, Tobian AA, Ravel J, Prodger JL, Serwadda D, et al. Penile microbiota and female partner bacterial vaginosis in Rakai, Uganda. MBio. 2015;6(3):e00589. Available at: https://pubmed.ncbi.nlm.nih.gov/26081632/ Accessed 8 Dec 2020Twin J, Bradshaw CS, Garland SM, Fairley CK, Fethers K, Tabrizi SN. The potential of metatranscriptomics for identifying screening targets for bacterial vaginosis. PLoS One. 2013;8(9):768-92.Marrazzo JM, Fiedler TL, Srinivasan S, Thomas KK, Liu C, Ko D, et al. Extravaginal reservoirs of vaginal bacteria as risk factors for incident bacterial vaginosis. J Infect Dis. 2012;205(10):1580-8.Alves P, Castro J, Sousa C, Cereija TB, Cerca N. Gardnerella vaginalis outcompetes 29 other bacterial species isolated from BV patients in an in vitro biofilm formation model. J Infect Dis. 2014;210(4):593-6.Ma B, Forney LJ, Ravel J. Vaginal microbiome: rethinking health and disease. Annu Rev Microbiol. 2012;66:371-89.Verstraelen H, Swidsinski A. The biofilm in bacterial vaginosis: implications for epidemiology, diagnosis and treatment. Curr Opin Infect Dis. 2013;26(1):86-9.Reid G, Brigidi P, Burton JP, Contractor N, Duncan S, Fargier E, et al. Microbes central to human reproduction. Am J Reprod Immunol. 2015;73(1):1-11.

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