Biological drugs prescription issues in terms of the new coronaviral infection COVID-19 pandemic. Literature review and clinical case

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Abstract

BACKGROUND: The spread of the novel coronaviral infection has set important medical society goals, such as the development of effective treatment and preventive modalities (including biologic agents) for COVID-19. Moreover, during this pandemic, the management of chronically ill patients that require immunosuppressive therapy is also a matter of great concern. Analysis of currently obtained data has concluded that patients treated with biologic agents have no elevated risk for COVID-19. Leading medical societies give an opinion in their clinical guidelines that management with biologic drugs should be continued during the COVID-19 pandemic. The feasibility of initiating treatment with a biologic agent depends on the risk-benefit ratio for the drug, the assessment of possible complications along with the associated risks for a poor outcome because of an underlying disease.

CASE REPORT: We present a case report of a patient with erythrodermic psoriasis and psoriatic arthritis treated with ixekizumab during COVID-19 quarantine.

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About the authors

L. S. Kruglova

Federal State Institution of Additional Postgraduate Education “Central State Medical Academy” Department for Presidential Affairs of the Russian Federation

Email: dr.polonskaia@gmail.com
ORCID iD: 0000-0002-5044-5265
Russian Federation, Moscow

E. A. Shatokhina

Federal State Institution of Additional Postgraduate Education “Central State Medical Academy” Department for Presidential Affairs of the Russian Federation

Email: dr.polonskaia@gmail.com
ORCID iD: 0000-0002-0238-6563
Russian Federation, Moscow

Alexandra S. Polonskaya

Federal State Institution of Additional Postgraduate Education “Central State Medical Academy” Department for Presidential Affairs of the Russian Federation

Author for correspondence.
Email: dr.polonskaia@gmail.com
ORCID iD: 0000-0001-6888-4760

MD

Russian Federation, Moscow

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Supplementary files

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2. Fig. 1. Dynamics of clinical manifestations of psoriasis in patient A. during treatment with a genetically engineered biological drug ixekizumab (TALS).

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3. Fig. 2. Dynamics of psoriasis severity indices during the course of therapy with ixekizumab in patient A.

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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