Gender, clinical and topographic features of the localized scleroderma lesions in anogenital area

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Abstract

Background: Currently, there is an increase in the number of skin lesions of anogenital localization, which is a “silent” epidemic, both due to the steady increase in the incidence of this pathology, and the interdisciplinary aspect of this problem.

Materials and methods: In the article, the authors first analyzed and presented the data of clinical and morphological analysis of 104 patients with various clinical variants of limited scleroderma, on the basis of which the main phenotypic and gender-specific clinical and topographical features of anogenital zone lesions in this group of patients are presented.

Results: Scleroatrophic lichen is one of the clinical variants of limited scleroderma, which is characterized by damage to the mucous membranes of the external genitals in both women and men. Lesions of such localization are late and often mistakenly diagnosed by specialists of related disciplines (obstetricians, gynecologists, urologists, family doctors, allergists, cosmetologists), which leads to high risks of developing genitourenal syndrome.

Conclusions: The development of scleroatrophic lesions in the anogenital zone is accompanied by pronounced clinical symptoms, including: itching, pain of varying intensity, dysuria, dyspareunia and significant sexual dysfunction.

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About the authors

Elena S. Snarskaya

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: snarskaya-doc@mail.ru
ORCID iD: 0000-0002-7968-7663

MD, PhD, DSc., professor of the Department of skin and venereal diseases of I.M. Sechenov First Moscow State Medical University (Sechenov University)

Russian Federation, Moscow

Yulia A. Semenchak

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: julia19921992@bk.ru
ORCID iD: 0000-0002-6608-0301
Russian Federation, Moscow

References

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Supplementary files

Supplementary Files
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2. Fig. 1. Distribution of patients with scleroatrophic lesions of anogenital localization by sex and age.

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3. Fig. 2. Scleroatrophic lesions of anogenital localization in patients with limited scleroderma.

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4. Fig. 3. Patient N., 55 years old. Plaque scleroderma. a - damage to the skin of the perianal region; b - lesion of the back skin.

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5. Fig. 4. Patient N., 49 years old. Lichen sclerosus with involvement of the labia majora and clitoris.

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6. Fig. 5. Patient K., 51 years old. Lichen sclerosus with lesions of the labia majora, clitoris, vaginal opening, remission.

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7. Fig. 6. Patient M., 55 years old. Lichen sclerosus with lesions of the labia majora, labia minora, clitoris, posterior commissures with transition to the anus.

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8. Fig. 7. Patient S., 45 years old. Lichen sclerosus with total involvement of the genitals and partial reduction of vaginal tissues, perimisia of the anus.

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9. Fig. 8. Patient D., 57 years old. Lichen sclerosus with lesions of the labia minora, clitoris, posterior commissure, perineum, and femoral folds.

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10. Fig. 9. Patient S., 53 years old. Combination of extragenital and genital lichen sclerosus in one patient.

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11. Fig. 10. Patient I., 56 years old. Combination of extragenital and the genital form of lichen sclerosus in one sick.

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12. Figure: 11. Lichen sclerosus with partial lesion tissues of the foreskin and glans penis.

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13. Fig. 12. Patient A., 37 years old. Lichen sclerosus with total damage to the skin of the trunk, glans penis, the urethra.

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14. Fig. 13. Patient M., 47 years old. Lichen sclerosus with multiple lesions of the skin of the trunk, scrotum and the glans of the penis.

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15. Fig. 14. Patient K., 41 years old. Lichen sclerosus trunk and the glans penis with partial loss of anatomical organ structure.

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16. Fig. 15. Lesion of the genitals with limited scleroderma.

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17. Fig. 16. Peculiarities of localization of genital lesions in women with limited scleroderma (n = 51).

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18. Fig. 17. Peculiarities of localization of genital lesions with limited scleroderma in men (n = 11).

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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