THE FEATURES OF THE CLINICAL MANIFESTATIONS OF THE VIRAL EXANTHEMA

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Currently there are about 200 different studied herpes viruses, only 8 types are pathogenic for humans. They all belong to the family Herpesviridae, which according to the structure of the virion and biological properties is divided into three subfamilies: α, β, and γ. Human herpesvirus 6B belongs to the subfamily of β-herpesvirus, genus Roseolovirus. The overview of current information on the etiology, epidemiology, clinical manifestations of infection caused by human herpesvirus 6B is presented. The diagnosis of the viral exanthema using modern laboratory technology is considered.

Full Text

Restricted Access

About the authors

Albina G. Pashinyan

Russian National Research Medical University n.a. N.I. Pirogov

Email: stsoagp4@gmail.com
MD, PhD, DSc, prof. of N.I. Pirogov Russian National Research Medical University, Moscow, 117997, Russian Federation. Moscow, 117997, Russian Federation

L. I Ilienko

Russian National Research Medical University n.a. N.I. Pirogov

Moscow, 117997, Russian Federation

A. N Akopyan

Russian National Research Medical University n.a. N.I. Pirogov

Moscow, 117997, Russian Federation

D. G Dzhavaeva

North Ossetian State Medical Academy

Vladikavkaz, 362019, Russian Federation

References

  1. Канкасова М.Н., Мохова О.Г., Поздеева О.С. Инфекционные экзантемы у детей Практическая медицина. 2015; 92(7): 26-31
  2. Savin K.W., Cocks B.G., Wong F., Sawbridge T., Cogan N., Savage D., Warner S. A neurotropic herpesvirus infecting the gastropod, abalone, shares ancestry with oyster herpesvirus and a herpesvirus associated with the amphioxus genome. Virol. J. 2010; 7: 308. doi: 10.1186/1743-422X-7-308.
  3. Roizman B., de-The G. Nomenclature and classification of herpesviruses: a proposal. Bull. World Health Organ. 1972; 46(4): 547-50.
  4. Филатова Т.Г. Герпесвирусная инфекция. Петрозаводск: Изд-во ПетрГУ; 2014.
  5. Кускова Т.К., Белова Е.Г. Семейство герпес-вирусов на современном этапе. Лечащий врач. 2004; 5: 28-30.
  6. Gompels U.A., Nicholas J., Lawrence G., Jones M., Thomson B.J., Martin M.E., et al. The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution. Virology. 1995; 209(1): 29-51.
  7. Komaroff A.L., Phan T., Flamand L., Pellett P.E. Summary of the 9th international conference on human herpesviruses 6 and 7 (HHV-6A, HHV-6B, and HHV-7). J. Med. Virol. 2016; 88(12): 2038-43. doi: 10.1002/jmv.24561.
  8. Salahuddin S.Z., Ablashi D.V., Markham P.D., Josephs S.F., Sturzenegger S., Kaplan M., et al. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders Science. 1986; 234 (4776): 596-601.
  9. Agut H., Bonnafous P., Gautheret-Dejean A. Update on infections with human herpesviruses 6A, 6B, and 7. Med. Mal. Infect. 2017; 47(2): 83-91. doi: 10.1016/j.medmal.2016.09.004.
  10. Schirmer E.C., Wyatt L.S., Yamanishi K., Rodriguez W.J., Frenkel N. Differentiation between two distinct classes of viruses now classified as human herpesvirus 6. Proc. Natl. Acad. Sci. USA. 1991; 88(13): 5922-6.
  11. Ablashi D., Agut H., Alvarez-Lafuente R., Clark D.A., Dewhurst S., DiLuca D., et al. Classification of HHV-6A and HHV-6B as distinct viruses. Arch. Virol. 2014; 159(5): 863-70. doi: 10.1007/s00705-013-1902-5.
  12. Mori Y., Yamanishi K. HHV-6A, 6B, and 7: pathogenesis, host response, and clinical disease. In: Arvin A., Campadelli-Fiume G., Mocarski E., eds. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge University Press; 2007: 833-42.
  13. Thader-Voigt A., Jacobs E., Lehmann W., Bandt D. Development of a microwell adapted immunoblot system with recombinant antigens for distinguishing human herpesvirus (HHV) 6A and HHV6B and detection of human cytomegalovirus. Clin. Chem. Lab. Med. 2011; 49(11): 1891-8.
  14. Arbuckle J.H., Medveczky P.G. The molecular biology of human herpesvirus-6 latency and telomere integration. Microbes. Infect. 2011; 13(8-9): 731-41.
  15. Tweedy J., Spyrou M.A., Pearson M., Lassner D., Kuhl U., Gompels U.A. Complete genome sequence of germline chromosomally integrated Human Herpesvirus 6A and analyses integration sites define a new Human Endogenous Virus with potential to reactivate as an emerging infection. Viruses. 2016; 8(1): pii: E19. doi: 10.3390/v8010019.
  16. Agut H., Bonnafous P., Gautheret-Dejean A. Laboratory and clinical aspects of human herpesvirus 6 infections. Clin. Microbiol. Rev. 2015; 28(2): 313-35. doi: 10.1128/cmr.00122-14.
  17. Ihira M., Yamaki A., Kato Y., Higashimoto Y., Kawamura Y., Yoshikawa T. Cycling probe-based real-time PCR for the detection of Human herpesvirus 6A and B. J. Med. Virol. 2016; 88(9): 1628-35. doi: 10.1002/jmv.24513.
  18. Yamanishi K., Okuno T., Shiraki K., Takahashi M., Kondo T., Asano Y., et al. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet. 1988; 1(8594): 1065-7.
  19. Wiersbitzky S., Eberle J., Ladstatter L., Bruns R., Hollinger.J, Deinhardt F., et al. New knowledge of Zahorsky exanthema subitum (critical 3-day fever-exanthema, roseola infantum. Kinderarztl. Prax. 1989; 57(4): 155-62.
  20. Stone R.C., Micali G.A., Schwartz R.A. Roseola infantum and its causal human herpesviruses. Int. J. Dermatol. 2014; 53(4): 397-403. doi: 10.1111/ijd.12310.

Statistics

Views

Abstract: 156

Dimensions

Article Metrics

Metrics Loading ...

PlumX


Copyright (c) 2017 Eco-Vector



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies