Retinoids in Dermatology: From Structure to Clinical Application

  • 作者: Olkhovskaya K.1, Vashkevich A.A.2
  • 隶属关系:
    1. Federal State Budgetary Institution of Higher Professional Education “Central State Medical Academy” of the Presidential Administration of the Russian Federation, Moscow
    2. Federal State Budgetary Educational Institution of Higher Education North-West State Medical University named after I.I. Mechnikov of the Ministry of Health of the Russian Federation, Saint Petersburg
  • 栏目: DERMATOLOGY
  • ##submission.dateSubmitted##: 07.05.2025
  • ##submission.dateAccepted##: 01.08.2025
  • ##submission.datePublished##: 22.09.2025
  • URL: https://rjsvd.com/1560-9588/article/view/678298
  • DOI: https://doi.org/10.17816/dv678298
  • ID: 678298


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详细

This work is devoted to a comprehensive analysis of the structure, functioning and biological significance of receptors in cellular signaling. The fundamental principles of receptor operation are considered, including classification, mechanisms of interaction with ligand molecules and the influence of external and internal factors on their activity. The main groups of receptors are described in detail: ionic, metabotropic and nuclear, as well as their molecular features and mechanisms of signal transmission inside the cell, when interacting with synthetic derivatives of vitamin A.

Particular attention is paid to the processes of activation and desensitization of receptors, which play a key role in the regulation of physiological processes. The molecular mechanisms of receptor function are discussed, including conformational changes, phosphorylation, and interaction with intracellular signaling proteins.

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作者简介

Kira Olkhovskaya

Federal State Budgetary Institution of Higher Professional Education “Central State Medical Academy” of the Presidential Administration of the Russian Federation, Moscow

编辑信件的主要联系方式.
Email: olhovskaya_kira@mail.ru
ORCID iD: 0000-0003-4920-5288
SPIN 代码: 9455-9482
Scopus 作者 ID: 24822936500
Researcher ID: MTE-39912025

Associate Professor, Associate Professor of the Department of Dermatovenereology and Cosmetology
 
俄罗斯联邦, st. Marshala Timoshenko, 19, bldg. 1A 121359, Moscow, Russia

Arina Vashkevich

Federal State Budgetary Educational Institution of Higher Education North-West State Medical University named after I.I. Mechnikov of the Ministry of Health of the Russian Federation, Saint Petersburg

Email: aavashk@mail.ru
ORCID iD: 0000-0002-3933-6922
SPIN 代码: 6254-9643
Scopus 作者 ID: 57220043869
Researcher ID: 3742-2014

Associate Professor, Associate Professor of the Department of Dermatovenereology and Cosmetology
 
俄罗斯联邦, Santiago de Cuba St., 1/28, 194291 Saint Petersburg, Russia

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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