Melanocytic nevus: Clinical features and colorimetrial evaluation

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BACKGROUND: An increase in the frequency of registration of skin malformations, benign, precancerous and malignant skin neoplasms requires new approaches to their diagnosis and treatment. The different depth of melanocytic nevi in the epidermis and dermis is reflected in the color of the melanocytic nevus.

AIM: to study the localization, size and intensity of pigmentation of melanocytic nevi depending on their color.

MATERIALS AND METHODS: A clinical and instrumental study of 280 people with melanocytic nevi of various localization was conducted using their colorimetric assessment and dermatoscopic diagnosis. If melanoma was suspected, patients were consulted by an oncologist. The diagnosis of "melanoma" was confirmed histologically.

RESULTS: Melanocytic nevi are more localized on the face than on the abdomen, back or chest, which is confirmed statistically. The largest sizes ― 5.5 mm ― are reached by nevi having a dark brown color, and, consequently, localized in the epidermis above the basal layer, and the smallest ― 2.0 mm ― melanocytic nevi with brown color located in the basal layer of the epidermis, which is also statistically confirmed.

CONCLUSION: The largest sizes ― 5.5 mm ― are reached by nevi having a dark brown color, and, consequently, localized in the epidermis above the basal layer, and the smallest ― 2.0 mm ― melanocytic nevi with brown color located in the basal layer of the epidermis.

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作者简介

Mariia Sakharova

North-Western State Medical University named after I.I. Mechnikov

Email: dr.marvl@mail.ru
ORCID iD: 0009-0000-3462-2666
SPIN 代码: 6791-8256
俄罗斯联邦, 47 Piskarevskii prospekt, 195067 Saint Petersburg

Svetlana Klyuchareva

North-Western State Medical University named after I.I. Mechnikov

编辑信件的主要联系方式.
Email: genasveta@rambler.ru
ORCID iD: 0000-0003-0801-6181
SPIN 代码: 9701-1400
Scopus 作者 ID: 53982986800
Researcher ID: AAH-7581-2019

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, 47 Piskarevskii prospekt, 195067 Saint Petersburg

Sergey Kashutin

Northern State Medical University

Email: sergeycash@yandex.ru
ORCID iD: 0000-0002-2687-3059
SPIN 代码: 7623-7216

MD, Dr. Sci. (Med.), Associated Professor

俄罗斯联邦, Arkhangelsk

Mikhail Levit

Northern State Medical University

Email: levitml@mail.ru
ORCID iD: 0000-0003-3255-9493
SPIN 代码: 4019-7625

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, Arkhangelsk

Natalya Shapchits

Northern State Medical University

Email: nata.shapchits@mail.ru
ORCID iD: 0009-0003-5411-1064
SPIN 代码: 5251-7555
俄罗斯联邦, Arkhangelsk

参考

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  2. Mordovtseva VV, Sergeev YuYu. Melanocytic nevi and melanoma of the skin: A practical guide to the diagnosis of melanocytic skin tumours. Ekaterinburg; 2022. 416 p. (In Russ).
  3. De Correa MP. Solar ultraviolet radiation: properties, characteristics and amounts observed in Brazil and South America. An Bras Dermatol. 2015;90(3):297-313. doi: 10.1590/abd1806-4841.20154089
  4. Prasad CP, Mohapatra P, Andersson T. Therapy for BRAFi-Resistant Melanomas: Is WNT5A the Answer? Cancers (Basel). 2015;7(3):1900-1924. doi: 10.3390/cancers7030868
  5. Pizzichetta MA, Massone C, Grandi G, et al. Morphologic changes of acquired melanocytic nevi with eccentric foci of hyperpigmentation (“Bolognia sign”) assessed by dermoscopy. Arch Dermatol. 2006;142(4):479-483. doi: 10.1001/archderm.142.4.479
  6. Aksenenko MB, Ruksha TG. Invasive capacity and proliferative activity of cutaneous melanoma and the epigenetic factor. Russ J Skin Venereal Dis. 2014;(5):4-8. (In Russ). EDN: SYCRTJ
  7. Akhmatova AM, Potekaev NN, Reshetov IV, et al. Early diagnostics of melanoma in dermatological practice. Russ J Clin Dermatol Venereol. 2012;10(2):32-36. EDN: PEJYSJ
  8. Barchuk AA, Podolsky MD, Gaidukov VS, et al. Intelligent distributed system for population screening of cancer. Problems Oncol. 2015;61(4):517-521. EDN: UBZBBB

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2. Fig. 1. Differentiation of melanocytic nevi by color: light brown (a), brown (b), dark brown (c).

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3. Fig. 2. The case of detected melanoma: cluster of melanocytic nevi in the dorsal region (a) and enlarged fragment of the detected neoplasm (b).

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4. Fig. 3. The case of detected melanoma: skin rashes on the skin of the scapular region (a) and an enlarged fragment of the neoplasm (b).

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