电邮这篇文章 Prevalence and etiology of onychomycosis in patients with psoriasis: a single-center study
- 作者: Kochergin N.G.1, Maximov I.S.1
-
隶属关系:
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- 期: 卷 24, 编号 1 (2021)
- 页面: 53-59
- 栏目: CLINICAL PICTURE, DIAGNOSIS, AND THERAPY OF DERMATOSES
- ##submission.dateSubmitted##: 25.02.2021
- ##submission.dateAccepted##: 17.03.2021
- ##submission.datePublished##: 15.02.2021
- URL: https://rjsvd.com/1560-9588/article/view/61804
- DOI: https://doi.org/10.17816/dv61804
- ID: 61804
如何引用文章
开放存取
##reader.subscriptionAccessGranted##
详细
BACKGROUND: Changes in nails with psoriasis are observed in 80–90% of patients. Pathological processes in the nail apparatus in patients with psoriasis are associated with both the underlying disease and the infectious nature.
AIMS: To evaluate the clinical features of the affected nail plates in patients with psoriasis, the prevalence and etiology of onychomycosis in patients with psoriasis with altered nail plates.
MATERIALS AND METHODS: 102 patients with psoriasis vulgaris, mild and moderate, stationary stage with altered nail plates were examined. A clinical and laboratory (microscopic and cultural) study of the affected nail plates was carried out.
RESULTS: After mycological studies and physical examination of the affected nails of 102 patients, the following groups of nail diseases in patients with psoriasis were identified: psoriatic onychodystrophy (76; 74.5%) patients, onychomycosis (30; 29.4%) patients, traumatic onycholysis (4; 3,9%) patient, onychocryptosis (3; 2.9%) patients. 11 (14.5%) patients with psoriatic onychodystrophy had a complication in the form of a fungal infection. Distal-lateral subungual form of onychomycosis was detected in 17 patients (56.7%), total dystrophic form ― in 10 patients (33.3%), white superficial form ― in 2 patients (6.6%), proximal subungual form ― in 1 patient (3.3%).
CONCLUSIONS: According to the results of clinical and mycological examination of the affected nails of patients with psoriasis, it was revealed that 74.5% of patients have manifestations of psoriatic onychodystrophy, 29.4% ― onychomycosis. Among patients with psoriatic onychodystrophy, 14.5% had a complication in the form of a secondary fungal infection. The main causative agents of onychomycosis are Candida spp. (63.3%). The incidence of dermatophytes (Trichophyton spp.) Was 36.7% of the total number of cases. The main clinical forms of onychomycosis in patients with psoriasis are distal-lateral (56.6%), total dystrophic (33.3%).
全文:
作者简介
Nikolay Kochergin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: nkocha@yandex.ru
ORCID iD: 0000-0001-7136-4053
Dr. Sci. (Med.), Professor
俄罗斯联邦, 8-2, Trubetskaya street, Moscow, 119992Ivan Maximov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
编辑信件的主要联系方式.
Email: maximov.is@mail.ru
ORCID iD: 0000-0003-2850-2910
MD, Assistant
俄罗斯联邦, 8-2, Trubetskaya street, Moscow, 119992参考
- Suskova VS, Pinson IYa, Olisova OYu. Immunopathological mechanisms of psoriasis. Russian Journal of Clinical Dermatology and Venereology. 2006;4(1):68-70. (in Russ)
- Olisova OYu. Teplyuk NP, Pinegin VB. Modern methodes of psoriasis treatment. Russian Journal of Medicine. 2015;(9):483-6. (in Russ)
- Pasch MC. Nail psoriasis: a review of treatment options. Drugs. 2016;76(6):675–705. doi: 10.1007/s40265-016-0564-5
- Salomon J, Szepietowski JC, Proniewicz A. Psoriatic nails: a prospective clinical study. J Cutan Med Surg. 2003;7(4):317–321. doi: 10.1007/s10227-002-0143-0
- Sviridova KV. Features of diagnosis and treatment of onychomycosis in psoriasis [dissertation abstract]. Saint Petersburg; 2009. 20 р. (In Russ).
- Trevisan F, Werner B, Pinheiro RL. Nail clipping in onychomycosis and comparison with normal nails and ungual psoriasis. An Bras Dermatol. 2019;94(3):344–347. doi: 10.1590/abd1806-4841.20198301
- Klaassen KM, Dulak MG, Van de Kerkhof PC, Pasch MC. The prevalence of onychomycosis in psoriatic patients: a systematic review. J Eur Acad Dermatol Venereol. 2014;28(5):533–541. doi: 10.1111/jdv.12239
- Tsentemeidou A, Vyzantiadis TA, Kyriakou A, et al. Prevalence of onychomycosis among patients with nail psoriasis who are not receiving immunosuppressive agents: Results of a pilot study. Mycoses. 2017;60(12):830–835. doi: 10.1111/myc.12681
- Kacar N, Ergin S, Ergin C, et al. The prevalence, aetiological agents and therapy of onychomycosis in patients with psoriasis: a prospective controlled trial. Clin Exp Dermatol. 2007;32(1):1–5. doi: 10.1111/j.1365-2230.2006.02215.x
- Leibovici V, Hershko K, Ingber A, et al. Increased prevalence of onychomycosis among psoriatic patients in Israel. Acta Derm Venereol. 2008;88(1):31–33. doi: 10.2340/00015555-0323
- Zisova L, Valtchev V, Sotiriou E, et al. Onychomycosis in patients with psoriasis ― a multicentre study. Mycoses. 2012;55(2):143–147. doi: 10.1111/j.1439-0507.2011.02053.x
- Stander H, Stander M, Nolting A. [Incidence of fungal involvement in nail psoriasis. (In German)]. Hautarzt. 2001;52(5):418–422. doi: 10.1007/s001050051335
- Rybin AV, Nesterov AS, Potaturkina-Nesterova NI, Nesterova AV. Etiological structure of onychomycosis in patients with psoriasis. Successes of Modern Natural Science. Russian Journal. 2011;(1):107–108. (In Russ).
- Rigopoulos D, Papanagiotou V, Daniel R, Piraccini B.M. Onychomycosis in patients with nail psoriasis: a point to point discussion. Mycoses. 2017;60(1):6–10. doi: 10.1111/myc.12542
- Ventura A, Mazzeo M, Gaziano R, et al. New insight into the pathogenesis of nail psoriasis and overview of treatment strategies. Drug Des Devel Ther. 2017;11:2527–2535. doi: 10.2147/DDDT.S136986
- Santiago K, Bomfim GF, Criado PR, Almeida SR. Monocyte-Derived dendritic cells from patients with dermatophytosis restrict the growth of trichophyton rubrum and induce CD4-T cell activation. PLoS One. 2014;9(11):e110879. doi: 10.1371/journal.pone.0110879
补充文件
