Primary cicatricial alopecia: a literature review

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The term cicatricial alopecia results from irreversible damage to epithelial stem cells located in the bulge region of the hair follicle with subsequent scarring. Based on the mechanism involved in follicular destruction, cicatricial alopecia is divided into primary and secondary forms. Primary cicatricial alopecia are divided into four groups according to their prominent inflammatory infiltrate: with lymphocytic, neutrophilic, mixed or nonspecific cell inflammation pattern.

The review presents the main clinical, histological and dermatoscopic signs of various types of primary cicatricial alopecia.

Full Text

Restricted Access

About the authors

Irina V. Zvezdina

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

Author for correspondence.
Email: zvezdinhome@mail.ru
ORCID iD: 0000-0002-5532-0672
SPIN-code: 2883-2408

Cand. Sci. (Med.), Assistant Professor

Russian Federation, 20/1, Delegatskaya street, Moscow, 127473

References

  1. Gusakov NI. History of Russian dermatovenerology. Moscow: Avvallon; 2007. 461 р. (In Russ).
  2. Harries MJ, Paus R. The pathogenesis of primary cicatricial alopecias. Am J Pathol. 2010;177(5):2152–2162. doi: 10.2353/ajpath.2010.100454
  3. Olsen E, Stenn K, Bergfeld W, et al. Update on cicatricial alopecia. J Investig Dermatol Symp Proc. 2003;8(1):18–19. doi: 10.1046/j.1523-1747.2003.12166.x
  4. Bolduc C, Sperling LC, Shapiro J. Primary cicatricial alopecia: Other lymphocytic primary cicatricial alopecias and neutrophilic and mixed primary cicatricial alopecias. J Am Acad Dermatol. 2016;75(6):1101–1117. doi: 10.1016/j.jaad.2015.01.056
  5. Zagrtdinova RM, Lyashenko NV, Zagrtdinova RN, Bychkova NYu. Alopecia: pathogenetic and clinical characteristics, treatment methods. Izhevsk : Izhevsk Statu Medicinae Academiae; 2016. 79 р. (In Russ).
  6. Mikhneva EN, Gavrilyuk AV. Diagnosis of Broca’s pseudopelada and discoid lupus erythematosus of the scalp using dermatoscopy. Dermatovenerology. Cosmetology. Sexopatology. 2011;(1-4):212–214. (In Russ).
  7. Zhulimova NL, Zilberberg NL, Rimar OG. Pseudopelade Brocq as a separate disease conformed by clinical and histological implications. Lechasсhi Vrach. 2014;(9):81–83. (In Russ).
  8. Kretz CC, Norpo M, Abeler-Dorner L, et al. Anti-annexin 1 antibodies: a new diagnostic marker in the serum of patients with discoid lupus erythematosus. Exp Dermatol. 2010;19(10):919–921. doi: 10.1111/j.1600-0625.2010.01145.x
  9. Rakowska A, Slowinska M, Kowalska-Oledzka E, et al. Trichoscopy of cicatricial alopecia. J Drugs Dermatol. 2012;11(6):753–758.
  10. Karadag Kose O, Gulec AT. Evaluation of a handheld dermatoscope in clinical diagnosis of primary cicatricial alopecias. Dermatol Ther (Heidelb). 2019;9(3):525–535. doi: 10.1007/s13555-019-0304-3
  11. Assouly P, Reygagne P. Lichen planopilaris: update on diagnosis and treatment. Semin Cutan Med Surg. 2009;28(1):3–10. doi: 10.1016/j.sder.2008.12.006
  12. Fedotova KYu, Zhukova OV, Kruglova LS, Ptashinsky RI. Lichen ruber planus: etiology, pathogenesis, clinical entities, histological pattern and the main treatment principles. Russian Journal of Clinical Dermatology and Venereology. 2014;12(6):9–20. (In Russ).
  13. Piguet V, Breathnach SM, Le Cleach L. Lichen planus and lichenoid disorders. In: Rook’s Textbook of Dermatology. Vol. 37. Oxford: Wiley-Blackwell; 2016. Р. 6–7. doi: 10.1002/9781118441213.rtd0038
  14. Kossard S. Postmenopausal frontal fibrosing alopecia. Scarring alopecia in a pattern distribution. Arch Dermatol. 1994;130(6):770–774.
  15. Kanti V, Constantinou A, Reygagne P, et al. Frontal fibrosing alopecia: demographic and clinical characteristics of 490 cases. J Eur Acad Dermatol Venereol. 2019;33(10):1976–1983. doi: 10.1111/jdv.15735
  16. Romanova YuYu, Gadzhigoroeva AG, Lvov AN. Classification and differential diagnosis of the frontal fibrosing alopecia. Russian Journal of Clinical Dermatology and Venereology. 2015;14(5):130–134. (In Russ).
  17. Tan KT, Messenger AG. Frontal fibrosing alopecia: clinical presentations and prognosis. Br J Dermatol. 2009;160(1):75–79. doi: 10.1111/j.1365-2133.2008.08861.x
  18. Vano-Galvan S, Molina-Ruiz AM, Serrano-Falcon C, et al. Frontal fibrosing alopecia: a multicenter review of 355 patients. J Am Acad Dermatol. 2014;70(4):670–678. doi: 10.1016/j.jaad.2013.12.003
  19. Dlova NC, Jordaan HF, Skenjane A, et al. Frontal fibrosing alopecia: a clinical review of 20 black patients from South Africa. Br J Dermatol. 2013;169(4):939–941. doi: 10.1111/bjd.12424
  20. Tolkachjov SN, Chaudhry HM, Camilleri MJ, Torgerson RR. Frontal fibrosing alopecia among men: a clinicopathologic study of 7 cases. J Am Acad Dermatol. 2017;77(4):683–690.e2. doi: 10.1016/j.jaad.2017.05.045
  21. Holmes S. Frontal fibrosing alopecia. Skin Therapy Lett. 2016;21(4):5–7.
  22. Diwan N, Gohil S, Nair PA. Primary idiopathic pseudopelade of brocq: five case reports. Int J Trichol. 2014;6(1):27–30. doi: 10.4103/0974-7753.136759
  23. Korsunskaya IM, Guseva SD, Nevozinskaya ZA. In quaestione de Brocq scriptor pseudopelade. Russian Journal of Clinical Dermatology and Venereology. 2015;14(3):17–21. (In Russ).
  24. Nair PA, Singhal R, Pariath K. Primary idiopathic pseudopelade of Brocq in a young child. Int J Trichol. 2017;9(3):113–115. doi: 10.4103/ijt.ijt_24_17
  25. Amato L, Mei S, Massi D, et al. Cicatricial alopecia; a dermatopathologic and immunopathologic study of 33 patients (pseudopelade of Brocq is not a specific clinico-pathologic entity). Int J Dermatol. 2002;41(1):8–15. doi: 10.1046/j.1365-4362.2002.01331.x
  26. Elston DM, McCollough ML, Warschaw KE, Bergfeld WF. Elastic tissue in scars and alopecia. J Cutan Pathol. 2000;27(3):147–152. doi: 10.1034/j.1600-0560.2000.027003147.x
  27. Rudnicka L, Olszewska M, Rakowska A. Atlas of Trichoscopy. Dermoscopy in Hair and Scalp Disease. Springer; 2012. Р. 339–344.
  28. Khumalo NP, Jessop S, Gumedze F, Ehrlich R. Hairdressing and the prevalence of scalp disease in African adults. Br J Dermatol. 2007;157(5):981–988. doi: 10.1111/j.1365-2133.2007.08146.x
  29. Olsen EA, Callender V, McMichael A, et al. Central hair loss in African American women: incidence and potential risk factors. J Am Acad Dermatol. 2011;64(2):245–252. doi: 10.1016/j.jaad.2009.11.693
  30. LoPresti P, Papa CM, Kligman AM. Hot comb alopecia. Arch Dermatol. 1968;98(3):234–238.
  31. Malki L, Sarig O, Romano MT, et al. Variant PADI3 in central centrifugal cicatricial alopecia. N Engl J Med. 2019;380(9):833–841. doi: 10.1056/NEJMoa1816614
  32. Herskovitz I, Miteva M. Central centrifugal cicatricial alopecia: challenges and solutions. Clin Cosmet Investig Dermatol. 2016;9:175–181. doi: 10.2147/CCID.S100816
  33. Miteva M, Tosti A. Pathologic diagnosis of central centrifugal cicatricial alopecia on horizontal sections. Am J Dermatopathol. 2014;36(11):859–864; quiz 865-7. doi: 10.1097/DAD.0000000000000174
  34. Miteva M, Tosti A. Dermatoscopic features of central centrifugal cicatricial alopecia. J Am Acad Dermatol. 2014;71(3):443–449. doi: 10.1016/j.jaad.2014.04.069
  35. Porteous ME, Strain L, Logie LJ, Herd RM, Benton EC. Keratosis follicularis spinulosa decalvans: confirmation of linkage to Xp22.13-p22.2. J Med Genet. 1998;35(4):336–337. doi: 10.1136/jmg.35.4.336
  36. Sanke S, Mendiratta V, Singh A, Chander R. Keratosis follicularis spinulosa decalvans with associated mental retardation: response to isotretinoin. Int J Trichol. 2017;9(3):138–139. doi: 10.4103/ijt.ijt_25_17
  37. Malvankar DD, Sacchidanand S. Keratosis follicularis spinulosa decalvans: a report of three cases. Int J Trichol. 2015;7(3):125–128. doi: 10.4103/0974-7753.167461
  38. Tosti A, Torres F. Dermoscopy in the diagnosis of hair and scalp disorders. Actas Dermosifiliogr. 2009;100(Suppl 1):114–119. doi: 10.1016/s0001-7310(09)73176-x
  39. Okhlopkov VA, Zubareva EYu, Radul EV. Quinquauds disease: a case study. Russian Journal of Clinical Dermatology and Venereology. 2018;17(1):30–33. (In Russ).
  40. Bernardez C, Molina-Ruiz AM, Requena L. Histologic features of alopecias: part II: scarring alopecias. Actas Dermosifiliogr. 2015;106(4):260–270. doi: 10.1016/j.ad.2014.06.016
  41. Mildzikhova DR, Sakaniya LR, Korsunskaya IM. Inverse acne: folliculitis et perifolliculitis capitis abscedens et suffodiens of Hoffman. Russian Journal of Clinical Dermatology and Venereology. 2018;17(4):110–113. (In Russ).
  42. Yutskovskaya YaA, Yutskovsky AD, Taran MG, Malova TA. A clinical event of perifolliculitis capitis abscedens et suffodiens of Hoffmann. Ukrainian Journal of Dermatology, Venerology, Cosmetology. 2012;(2):33–39. (In Russ).
  43. Lee CN, Chen W, Hsu CK, et al. Dissecting folliculitis (dissecting cellulitis) of the scalp: a 66-patient case series and proposal of classification. J Dtsch Dermatol Ges. 2018;16(10):1219–1226. doi: 10.1111/ddg.13649
  44. Melo DF, Lemes LR, Pirmez R, Duque-Estrada B. Trichoscopic stages of dissecting cellulitis: a potential complementary tool to clinical assessment. An Bras Dermatol. 2020;95(4):514–517. doi: 10.1016/j.abd.2019.10.008
  45. Salami T, Omeife H, Samuel S. Prevalence of acne keloidalis nuchae in Nigerians. Int J Dermatol. 2007;46(5):482–484. doi: 10.1111/j.1365-4632.2007.03069.x
  46. Ogunbiyi A. Acne keloidalis nuchae: prevalence, impact, and management challenges. Clin Cosmet Investig Dermatol. 2016;9:483–489. doi: 10.2147/CCID.S99225
  47. Lozano Pena АК, Flores MG, Candiani JO. Primary cicatricial alopecia, diagnosis and treatment updates. Dermatologia CMQ. 2017;15(4):255–264.
  48. Sperling LC, Homoky C, Pratt L, Sau P. Acne keloidalis is a form of primary scarring alopecia. Arch Dermatol. 2000;136(4):479–484. doi: 10.1001/archderm.136.4.479
  49. Kossard S, Collins A, McCrossin I. Necrotizing lymphocytic folliculitis: the early lesion of acne necrotica (varioliformis). J Am Acad Dermatol. 1987;16(5 Pt 1):1007–1014. doi: 10.1016/s0190-9622(87)80408-5
  50. Nikolic M, Peric J, Skiljevic D. Acne necrotica (Varioliformis) — case report. Serbian J Dermatol Venereol. 2019;11(3):94–97. doi: 10.2478/sjdv-2019-0014
  51. Pitney LK, O’Brien B, Pitney MJ. Acne necrotica (necrotizing lymphocytic folliculitis): An enigmatic and under-recognised dermatosis. Australas J Dermatol. 2018;59(1):e53–e58. doi: 10.1111/ajd.12592
  52. Vaccaro M, Guarneri C, Barbuzza O, Guarneri B. Erosive pustular dermatosis of the scalp: an uncommon condition typical of elderly patients. J Am Geriatr Soc. 2008;56(4):761–762. doi: 10.1111/j.1532-5415.2008.01615.x
  53. Vaccaro M, Barbuzza O, Guarneri B. Erosive pustular dermatosis of the scalp following treatment with topical imiquimod for actinic keratosis. Arch Dermatol. 2009;145(11):1340–1341. doi: 10.1001/archdermatol.2009.278
  54. Thuraisingam T, Mirmirani P. Erosive pustular dermatosis: a manifestation of immunosenescence a report of 8 cases. Skin Appendage Disord. 2018;4(3):180–186. doi: 10.1159/000484488
  55. Starace M, Loi C, Bruni F, et al. Erosive pustular dermatosis of the scalp: Clinical, trichoscopic, and histopathologic features of 20 cases. J Am Acad Dermatol. 2017;76(6):1109–1114.e2. doi: 10.1016/j.jaad.2016.12.016
  56. Starace M, Patrizi A, Piraccini BM. Visualization of hair bulbs through the scalp: a trichoscopic feature of erosive pustular dermatitis of the scalp. Int J Trichol. 2016;8(2):91–93. doi: 10.4103/0974-7753.188038

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2021 Eco-Vector



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 86501 от 11.12.2023 г
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 80653 от 15.03.2021 г
.



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies