Development of scalded skin syndrome in an adult patient with acquired epidermolysis bullosa after long-term treatment with methotrexate

A clinical case of a patient with epidermolysis bullosa acquisita, which is a rare autoimmune disease ― 0.17–0.26 cases per 1 million population, with the development, most likely against the background of long-term cytostatic therapy with methotrexate, develops staphylococcal scalded skin syndrome is presented.

Staphylococcal scalded skin syndrome is a lesion that appears in 0.09–0.56 cases per 1 million and is predominantly observed in newborns and children under 5 years of age, and cases in adults are usually associated with immunosuppression, human immunodeficiency virus / acquired immunodeficiency syndrome, severe renal failure or malignant neoplasms.

The article presents literature data on the etiology and pathogenesis of the presented diseases, features of differential diagnosis, description of clinical and laboratory criteria, on the basis of which diagnoses are made.

This clinical case is of interest to dermatologists, as it describes the scalded skin syndrome, which is rare in everyday practice, in a patient with acquired epidermolysis bullosa, which, despite ongoing therapy, has a risk of death of up to 65%.