Vol 20, No 3 (2017)

A description of a rare disease multiple steatocystoma is presented. The disease is characterized by the development of cysts of hair follicle walls and sebaceous gland ducts. Clinical signs are multiple yellow-colored nodules located in the areas with high density of sebaceous glands. Description of clinical case of multiple steatocystoma at 31-year-old female patient, that was treated for a long time with an “unknown dermatosis” and literature review are presented. The correct diagnosis was verified based on anamnesis, clinical findings and pathomorphologic study.

Case of a rare form of vegetating true acantholytic pemphigus with atypical manifestations on the face and scalp, interpreted as skin cancer, is described. The process was accompanied by the generation of high level of immunoglobulin G only to desmoglein type 3. This example demonstrates the difficulty in the diagnostics of true pemphigus not only for general doctors of different specialties but also for dermatologists.

Clinical case of patient with rashes on mucous membrane of oral cavity with severe pain, edema, redness, deformation of eyelids on both eyes and decreased visual acuity is presented. After examination by several specialists (dentist, ophthalmologist and dermatologist) cicatricial pemphigoid with primary lesion of eyes was diagnosed. Authors point out doctors on danger of serious complications of this disease, which demand active involvement of doctors of other specialties.

Increasing the effectiveness of treatment and restoring the quality of life in patients with moderate to severe and severe forms of psoriasis is one of the most important trends in modern dermatology. The appearance of biological products in the late XXth century opened new opportunities in the treatment and control of the course of the disease in patients suffering from moderate and severe forms of psoriasis. Conducting maintenance system treatment with biological products reduces the severity of course of dermatosis, and in some cases prevents the occurrence of disease relapses. Despite the increasing popularity of anti-cytokine drugs, there are difficulties in the treatment of choice of the therapy in some cases. Among the main reasons for the lack of response to ongoing biological therapy are the genetic characteristics of the patient and the immunogenicity of the drugs. Failures in the use of biological therapy can also result a low concentration of the drug before the next administered dose. It has been proven that the combined use of methotrexate and infliximab inhibits the development of anti-drug antibodies that are associated with the development of a low therapeutic response. The article describes the clinical observation of a patient suffering for 20 years from a severe form of psoriasis and psoriatic arthritis. The experience of long-term (about 10 years) prescription of the biological preparation infliximab with sufficient clinical response without additional use of methotrexate is shown. The results of successful combined therapy of psoriatic erythroderma and psoriatic arthritis with infliximab and acitretin in order to reduce the immunogenicity of the tumor necrosis factor α blocker and avoid the ”escape” effect are described. The data of restoration of a good therapeutic response to systemic biological therapy with infliximab after administration of acitretin are presented.

Correction of facial hyperpigmentation is a very common and complex problem faced by dermatologists, cosmetologists and plastic surgeons. Recently developed microplasma radiofrequency technology allows to accurately and rapidly affect the areas with hyperpigmentation and is an effective method of its treatment. The aim of this study is to evaluate the effectiveness of hyperpigmentation treatment using microplasma radiofrequency technology. The study included 35 patients with benign hyperpigmentation with localization on the face. All patients had II - IV skin phototypes according to Fitzpatrick. We used a device with an output power of 60-90 W and performed 2-6 passes (rolling with a roller nozzle) in different directions. Three to five procedures were performed with 8-week intervals. As a result of treatment, all patients had improvement, which is manifested in clarification of hyperpigmentation spots of varying severity. Complications were not observed. Improvement of skin condition with reduction of hyperpigmentation phenomena was assessed by patients and physicians who compared digital images taken before the treatment and 2 months after the last procedure. The results of the study showed that the patients had a positive effect on the treatment of hyperpigmentation using microplasma radio frequency technology. The average index of pain intensity was estimated from 0 to 10 using a visual analog scale, which was 6.7 ± 0.7. After a course of therapy in 32 of 35 patients hyperpigmentation decreased by more than 51%, and 3 patients managed to achieve a clinical cure. The average improvement in the treatment of hyperpigmentation was 4.28. Thus, microplasma radiofrequency technology is a highly effective and safe method of treating facial hyperpigmentation.

Purpose - to conduct clinical and epidemiological analysis of the incidence of neurosyphilis in the Omsk region in the period from 2008 to 2015. Material and methods. The assessment of level of a condition of a case rate of various groups of the population and implication of epidemic process carried out on the basis of the analysis of data of the statistical account on Omsk and the Omsk region and statistical cards of the patients. Complex clinical examination of patients with a lues for the purpose of identification of signs of a lesion of a nervous system is conducted. Results. The analysis of an epidemic situation in Omsk and the Omsk region for the specified period of observations showed that the case rate a neurolues of the population of the region remained stable. Conclusion. Now depression of the general case rate by a neurolues with symptoms against body height of a case rate an asimptomny neurolues is observed. In the conditions of body height of a case rate an asimptomny neurolues closer interaction of dermatovenerologists and neurologists in questions of diagnostics and treatment of a neurolues is necessary.