Vol 13, No 5 (2010)

The paper reports a case of multiple nevus spilus (two foci on the back and shoulder) concurrent with type 1 psoriasis in a 22-year-old woman.

The paper gives new information on the immunopathogenesis of pyoderma of various etiologies. Imbalance has been found in the system of idiotypic and antiidiotypic antibodies to interferon-γ and antiidiotypic antibodies. Their level and ratio are shown to correlate with the severity and duration of pyoderma.

The paper reviews an update on the pathogenesis and clinical features of acne inverse. It describes the authors' cases of this rare and severe form of acne. The problems of the timely diagnosis and efficient treatment of this pathology are discussed.

The paper first describes a case of secondary erythroderma occurring in the parasitic disease. The differential diagnosis of different forms of erythroderma should consider the following factors: age, a history of dermatoses, use of drugs, and parasitic infestation. Since erythroderma may rapidly develop in lymphoproliferative diseases, the efficiency of differential diagnosis of erythrodermic skin lesions in cutaneous T-cell lymphoma is analyzed and the current treatment regimen for skin lesions in toxocarosis given. The findings suggest the high efficiency of treatment.

One hundred and seven patients (99 males and 8 women) aged 30-68 years (mean age 49.3±2.3 years) with porphyria cutanea tarda (PCT) identical in main clinical and statistical indicators were examined in 2 administrative areas of the Siberian Region (Irkutsk and Novosibirsk Regions) during 12 years (1998-2009). Enzyme immunoassay revealed a total of hepatitis C virus antibodies in 47 (43.9%) patients, including 12 (44.4±9.7%) of 27 patients from the Irkutsk Region and 35 (43.8±5.5%) of 80 patients from the Novosibirsk Region) (p > 0.5). Polymerase chain reaction found hepatitis C virus (HCV) RNA (viral load 105-106 copies/ml) in virtually all the examinees, which was indicative of the active course of infection at the stage of HCV replication. Genotyping indicated that HCV genotype 1b was dominant (91.3%) in the Siberian Region of Russia, as in other countries of the Eurasian and American continents, whereas genotype 3a was less frequently recorded (8.7%). Differential assessment of the dermatologic syndrome PCT, the age periods of manifestations of the disease, the specific features of its seasonal course, and daily urinary porphyrin excretion demonstrated that there were no great differences in patients with HCV infection versus those without viral hepatic lesion. However, hepatic dysfunctions were significantly more frequently detectable when PCT was concurrent with HCV infection, which was naturally attended by enhanced transaminase activities and higher iron levels in the serum. HCV plays an important etiological role in PCT and should be considered in this disease as a trigger, the porphyrinogenic effect of which is shown in combination with other risk factors (chronic alcohol intoxication, iron overload syndrome).

The authors describe the rare hereditary disease Touraine's congenital polykeratosis and give the data available in the literature and their observation of this dermatosis in a 14-year-old girl.

The paper describes a case of the malignant course of a secondary syphilis period. It provides the clinical characteristics of the infection and patient management tactics.

The study was undertaken to optimize therapy for vulvovaginal candidiasis in the presence of chronic inflammatory diseases of small pelvic organs, by topically using immunoregulatory peptides (myelopide, superlymph). Local immunotherapy with these agents was shown to be promising in multimodality treatment programs for vulvovaginal candidiasis in the presence of chronic inflammatory diseases of small pelvic organs.