Vol 15, No 1 (2012)

Authors present results of long-term (2001-2010) observational assessment of efficacy of cryodestruction for basal cell carcinoma in 202 patients with 230 lesions. The best clinical and cosmetic results were achieved in Т1N0M0 stage of histologically monomorphous tumors, whereas in other tumor variants the effect was less favourable. Authors conclude that development of new treatment methods of nodular, ulcerative and scleroderma-like variants of basalioma are needed.

A case of squamous cell carcinoma originating from lupus erythematosus lesions is presented.

A case of actinic reticuloid is presented. Actinic reticuloid is a variant of skin pseudolymphoma. This photodermatosis manifests with erythematous and nodular lesions, histologically mimicking malignant T-cell lymphoma (mycosis fungoides). 12 Russian and foreign publications are reviewed.

Review of Russian and foreign literature is presented concerning manifestation of Favre-Racouchot disease triggered by different factors. A case of coincidence of Favre-Racouchot disease and superficial basalioma is described. Bibliography includes 16 items.

Authors characterize peculiarities of metabolic disorders in chronic disseminated severe dermatoses (psoriasis, atopic dermatitis, pemphigus). There is a common feature in all evaluated disorders: increase of such markers of endoitoxication as intermediate mass molecules (IMM), activation of oxidation of peptides and lipids, decrease of effective albumin concentration. These changes can be interpreted as common biologic reaction to damage. Specificity of metabolic reactions was reflected in different mechanisms of generation of substrate of endointoxication, which were revealed due to qualitative differences of IMM spectrum and conditional compensatory changes in proteolytic systems of organism, as well as different types of formation of immune complexes.

Authors review mechanisms of action of activated zinc pyrithion (Skin-cap preparation) in different inflammatory dermatoses (including complicated with secondary bacterial or fungal infection), allowing achievement of pronounced anti-inflammatory, proapoptogenic and antibacterial/antimycotic effect in patients with psoriasis, eczema, atopic and seborrheic dermatitis. A case of patient with psoriasis is presented with clinical remission after 14 days of treatment with Skin-cap aerosol.

Authors present results of successful complex treatment of 34 patients with different scleroatrophic skin lesions (chronic atrophic acrodermatitis, circumscribed scleroderma, lichen sclerosus et atrophicus, atrophoderma Pasini-Pierini, linear scleroderma), associated with borrelia infection. Treatment consisted of 1-3 courses, which included ceftriaxon, longidase, angiotropic and medications, and topical Egallokhit. Results of the study are presented as well as review of Russian and foreign literature (26 sources).

A case of metotrexat induced toxicoderma is presented. Authors present short historical data concerning use of metotrexat in medicine, its' mechanism of action and possible side effects of the drug.

Authors analyze dermatoses most common in persons, going in for sports including aquatic sports. Factors, influencing skin microflora are presented concerning sportsmen of 4 groups: pentathlon, athletic swimming, synchronised swimming and water polo.

Authors present results of the first part of complex clinical and laboratory examination of 92 (100%) men of childbearing age including assessment of standard methods of clinical and laboratory diagnostics. Results of the study confirm the data of Russian and foreign authors illustrating reduction of etiological role of С.trachomatis and Т.vaginalis in non-gonococcal urethritis from 30-50 to 15% and increase of etiological role of opportunistic pathogenic bacteria, viruses and their associations.