Photogallery. Sarcoidosis (part 1)

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Abstract

Sarcoidosis (synonym: Benier–Beck–Schaumann disease, benign granulomatosis, chronic epithelioid cell reticuldoendotheliosis) ― is a multisystem disease from the group of granulomatosis, of unknown etiology, the morphological feature of which is the development of epithelioid cell granulomas without caseous necrosis fibrosis in the tissues of various organs. Taking into account the variety of clinical lesions, there are three main forms: extrathoracic, intrathoracic, mixed (generalized).

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About the authors

Elena S. Snarskaya

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: snarskaya-dok@mail.ru
ORCID iD: 0000-0002-7968-7663

MD, PhD, DSc, Professor, Department of Skin and Venereal Diseases

Russian Federation, 8 buil. 2 Trubetskaya street, 119991 Moscow

Natalia P. Teplyuk

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: teplyukn@gmail.com
ORCID iD: 0000-0002-5800-4800
Russian Federation, 8 buil. 2 Trubetskaya street, 119991 Moscow

References

Supplementary files

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1. Fig. 1. Patient P., 34 years old: а ― Beck's small-nodular sarcoid in combination with cicatricial form of sarcoidosis; б ― the same patient, a fragment of a site of cicatricial atrophy on the scalp with elements of a small-nodular sarcoid, a symptom of Broca's pseudopellas.

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2. Fig. 2. Patient I., 56 years old. Beck's small-nodular sarcoid. Multiple rashes on the skin of the face.

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3. Fig. 3. Patient Ya., 37 years old. Beck's multiple small-nodular sarcoid. Rashes on the skin of the lower extremities, do not merge, on palpation of a densely elastic consistency, painless.

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4. Fig. 4. Patient L., 37 years old. Beck's multiple small-nodular sarcoid. Rashes on the skin of the trunk, do not merge, on palpation of a densely elastic consistency, painless.

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5. Fig. 5. Patient B., 28 years old. Widespread deep subcutaneous and large-nodular Beck's sarcoid of the trunk and upper extremities.

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6. Fig. 6. Patient D., 56 years old. Beck's large nodular sarcoid. It is distinguished by the presence of a few hemispherical and flat nodules with a diameter of 0.8–1 cm of violet-pink, sometimes brown color with a smooth surface, with regression of which, telangiectasias appear on the surface. Usually, regression begins in the central part and ends with cicatricial atrophy.

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7. Fig. 7. Patient P., 61 years old: а ― diffuse-infiltrative Beck's sarcoid according to the type of Bénier-Tennesson's lupus fever. It is a combination of large-nodular and diffuse-infiltrative forms of sarcoids. It is localized on the skin of the nose and adjacent areas of the cheeks (butterfly as in lupus erythematosus), as well as in the area of the auricles, chin, forehead, less often fingers and toes; б ― fragment of the cheek: pronounced infiltration and telangiectasia. The process intensifies in the cold season. Regression of the rash leaves cicatricial atrophy.

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8. Fig. 8. Patient N., 27 years old: а ― large-nodular and small-nodular Beck's sarcoid It is characterized by the formation of smooth dense reddish-violet nodules with a diameter of 2–7 mm to 2–3 cm, localized on the skin of the face and trunk; б ― fragment of Beck's small-nodular sarcoid; в ― fragment of Beck's small-nodular sarcoid of the skin of the inner surface of the upper arm; г ― a fragment of Beck's large-nodular sarcoid of the trunk skin.

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9. Fig. 9. Patient D., 34 years old: а ― Beck's small-nodular sarcoid: facial skin lesions; б ― positive symptom of "apple jelly" during diascopy.

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10. Fig. 10. Patient J., 54 years old: а ― diffuse-infiltrative Beck's sarcoid. It is characterized by the formation of plaques on the skin of the face, more often in the cheeks, less often on the body in the form of a flat infiltrative plaque of violet-pink color with a diameter of 5–6 cm or more. The phenomenon of "dust particles" is positive; б ― deep subcutaneous sarcoid of Darier–Russi: rash in the form of infiltrates on the skin of the upper extremities.

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11. Fig. 11. Patient T., 66 years old. Atypical variant of sarcoidosis: Broca-Potrie's angiolupoid. It is distinguished by a single soft, slightly towering cyanotic-red plaque with a diameter of 2–3 cm with multiple telangiectasias on the surface. It is localized almost exclusively on the skin of the nose. May resolve spontaneously.

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12. Fig. 12. Patient E., 26 years old. Beck's large nodular sarcoid. A single lesion on the skin of the forehead.

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13. Fig. 13. Patient Y., 68 years old. Nonspecific skin manifestations of sarcoidosis in the form of a perforating form of annular granuloma. Sarcoidosis of the intrathoracic lymph nodes.

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14. Fig. 14. Patient P., 71 years old: а ― deep subcutaneous sarcoid Darier–Russi. Symmetrical lesion of both cheeks, nasal skin. It is characterized by a lesion of the hypodermis, where large painless nodes with a diameter of up to 5 cm are formed, the skin over which gradually acquires a pinkish color, when soldering to the skin, the symptom of "orange peel" appears, and when the nodes merge, the symptom of "cobblestone pavement" appears; б ― fragment of the cheek skin: persistent telangiectasias with deep subcutaneous sarcoid Daria–Russi.

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15. Fig. 15. Patient S., 45 years old. Nonspecific skin manifestations of sarcoidosis in the form of a perforating granuloma annular on the skin of the temporal region. Sarcoidosis of the intrathoracic lymph nodes. Disseminated multiple lesions on the skin of the face, chest, upper limbs. Eruptions in the form of annular elements from 2 to 5 cm in diameter, while the central zone with fibrinoid layers, under which the erosive and ulcerative surface.

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16. Fig. 16. Patient T., 31 years old. Beck's small-nodular sarcoid. Multiple eruptions on the skin of the trunk.

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