What do we know about osteoma cutis? Literature review. Clinical cases

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Abstract

This article summarises the data of epidemiology, etipathogenesis, a clinical picture, diagnosis and the treatment of osteoma cutis. The classification, a histological picture, the place of osteoma cutis from the point of view of the phenotype in relation to the information of the world literature are presented.

Osteoma cutis is a rare benign disease characterised by the formation of the bone tissue in the dermis or subcutaneous fat. Two theories of the origin of osteoma cutis are of particular interest: the result of fibroblast metaplasia into osteoblasts or the differentiation of primitive mesenchymal cells into osteoblasts and their migration to an ectopic site. Diagnosis and differential diagnosis are based on the clinical examination, measurement of calcium, parathyroid hormone, x-ray and skin biopsy. The differential diagnosis involves many dermatoses, including ossified hair follicle, osteosarcoma, epidermoid cysts, fibromas, neurofibromas, basal cell carcinoma, etc. The approach to the treatment is to use non-invasive or invasive methods: tretinoin cream, dermabrasion and punch biopsy, YAG laser, scalpel excision, curettage and CO2 laser.

We consider skin osteoma to be an underestimated dermatosis, since we have not found descriptions of such cases in reviews in the available Russian literature.

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About the authors

Elena S. Snarskaya

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: snarskaya-dok@mail.ru
ORCID iD: 0000-0002-7968-7663
SPIN-code: 3785-7859

MD, PhD, DSc., professor

Russian Federation, 8 build 2 Trubetskaya street, Moscow, 119991

Natalia P. Teplyuk

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: teplyukn@gmail.com
ORCID iD: 0000-0002-5800-4800
SPIN-code: 8013-3256

MD, PhD, DSc., professor

Russian Federation, 8 build 2 Trubetskaya street, Moscow, 119991

Ksenia D. Vasileva

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: kseniya07101988@mail.ru
ORCID iD: 0000-0001-8693-9622
SPIN-code: 5834-5044

ordinator of the Department of skin and venereal diseases

Russian Federation, 8 build 2 Trubetskaya street, Moscow, 119991

Ekaterina Yu. Vertieva

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: ivertieva@gmail.com
SPIN-code: 3712-8453

Candidate of Medical Sciences, Research Officer

Russian Federation, 8 build 2 Trubetskaya street, Moscow, 119991

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Supplementary files

Supplementary Files
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1. Fig. 1. Patient K, 56 years old. Frontotemporal osteomas.

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2. Fig. 2. Patient K, 56 years old. The procedure for excision of osteoma on the skin of the breast.

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3. Fig. 3. Patient K, 56 years old. Removed osteoma.

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4. Fig. 4. Osteomas cutis.

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5. Fig. 5. Pathomorphological examination.

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6. Fig. 6. Patient S., 34 years old. Multiple osteomas of the forehead skin.

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7. Fig. 7. The same patient. Сondition after removal of skin osteomas.

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8. Fig. 8. Osteomas cutis.

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