Skin sebum level VS pH in acne vulgaris



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Abstract

Background: Modern research considers acne as a disease accompanied by the development of epidermal barrier defects. Restoration of epidermal barrier parameters is a new direction in the context of acne treatment, therefore, the search for means that can successfully reduce acne manifestations and restore epidermal barrier disorders is an current task.

Aims: to determine the efficacy and safety of the “LA-KRY®” STOP ACNE with an innovative sebum-regulating complex in adolescents with mild acne.

Material and methods: a prospective single-center observational program was conducted at the St. Petersburg State Pediatric Medical University from May to December 2024. 30 patients with mild acne, whose legal representatives signed voluntary informed consent were included in programm. The participants used a complex of cosmetic products 2 times a day for 84 days. The program included 4 visits, each of which included an objective examination with counting of rash elements, assessment of moisture, sebum, pH, skin erythema using the Multi Skin Test Center 750 device (Germany), collection of data on adverse events, assessment of quality of life and satisfaction with the use of external agents.

Results: 30 patients with mild acne aged 11 to 17 years (average age 14.5 years, 13 boys, 17 girls) completed the program according to plan. Partial and complete regression of rashes was recorded in all program participants. The average number of comedones in the observation group decreased by 82.9%; papules/pustules - by 86.2%, inflammatory elements - by 91.2%. There was a 21% decrease in facial skin erythema, a 3.4% increase in hydration, a 37.7% decrease in sebum level, a 12.6% shift in acidity to the acidic side, and an improvement in quality of life according to the CDLQI questionnaire by 51.7%. No adverse events were observed in patients while using the studied external agents. 97% (29/30) of patients rated their experience of participating in the program as excellent.

Conclusion: A set of cosmetic products with sebum-regulating complex in the composition can be recommended as an additional therapy or an isolated care regimen that meets all the requirements for efficacy and safety for adolescents with mild acne. This therapy is aimed not only at combating the clinical manifestations of acne, but is also able to replenish the defects of the epidermal barrier and thereby prevent the appearance of rashes.

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About the authors

Denis Vladimirovich Zaslavsky

Saint-Petersburg State Pediatric Medical University

Author for correspondence.
Email: venerology@gmail.com
ORCID iD: 0000-0001-5936-6232
SPIN-code: 5832-9510

Honored Doctor of Russian Federation, DSc, professor of the Department of Dermatovenereology

Russian Federation, 194100, 2A Litovskaya street, Saint-Petersburg, Russian Federation

Alexey Viktorovich Taganov

LCC French clinic of skin diseases named after Piere Wolkenstein

Email: matis87177@yandex.ru
ORCID iD: 0000-0001-5056-374X
SPIN-code: 1191-8991

DSc, Dermatovenereologist

Russian Federation, 191123, 24Ryleeva street, Saint-Petersburg, Russian Federation

Daria Vasilevna Kozlova

1. Saint-Petersburg State Pediatric Medical University

3. Russian Scientific Center of Radiology and Surgeon Technologies

Email: Dashauchenaya@yandex.ru
ORCID iD: 0000-0002-6942-2880
SPIN-code: 3783-8565

1. Assistant of the Department of Dermatovenereology

 

3. Phd student of the Department of Radiology, Surgery and Oncology

Russian Federation, 1.194100, 2A Litovskaya street, Saint-Petersburg, Russian Federation 3. 197758, 70, Leningradskaya street, Saint-Petersburg, Russian Federation

Svetlana Yurievna Kulikova

Saint-Petersburg State Pediatric Medical University

Email: svet22_07@mail.ru
ORCID iD: 0009-0002-5987-8099
SPIN-code: 9685-5678

Dermatovenereologist, Cosmetologist, Assistant of the Department of Dermatovenereology

Russian Federation, 194100, 2A Litovskaya street, Saint-Petersburg, Russian Federation

Mikhail Georgievich Khvedelidze

Saint-Petersburg State Pediatric Medical University

Email: sussll@yandex.ru
ORCID iD: 0000-0002-2017-090X
SPIN-code: 8553-8384

PhD, assistant of the Department of Dermatovenereology

Russian Federation, 194100, 2A Litovskaya street, Saint-Petersburg, Russian Federation

Ekaterina Antonovna Lyamina

Saint-Petersburg State Pediatric Medical University

Email: katerina_lyamina00@mail.ru
ORCID iD: 0009-0005-1932-3373
SPIN-code: 4777-1850

Pediatrician, Resident of the department of Dermatovenereology

Russian Federation, 194100, 2A Litovskaya street, Saint-Petersburg, Russian Federation

Gulay Alisafaevna Manafova

Saint-Petersburg State Pediatric Medical University

Email: gul-manafova2017@yandex.ru
ORCID iD: 0009-0005-9064-4022

student of the 6th cource 

Russian Federation, 194100, 2A Litovskaya street, Saint-Petersburg, Russian Federation

Kirill Dmitrievich Dyatlov

North-West State Medical University named after I.I. Mechnikov

Email: thorimsson@yandex.ru
ORCID iD: 0009-0008-8960-1449

Student of the 6th cource

Russian Federation, 191015, 41 Kirochnaya street, Saint-Petersburg, Russian Federation

Nikolay Nikolaevich Aletskiy-Milyutin

JSC «WERTEX»

Email: aletskiy.nn@gmail.com
ORCID iD: 0009-0001-1031-720X
SPIN-code: 7831-6314

Dermatovenereologist, Senior specialist in the direction of medical support of business, Medical Adviser 

Russian Federation, 197350, 62А Doroga v Kamenku, Saint-Petersburg, Russian Federation

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