New opportunities in the treatment of cutaneous lymphoid hyperplasia

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Here, we present the results of our research regarding the efficacy of photodynamic therapy (PDT) in cutaneous lymphoid hyperplasia (CLH). We observed five patients with CLH. The diagnoses were confirmed both clinically and through laboratory testing. The response to treatment was defined by the index of the modified assessment of the severity of the skin lesions scale (mSWAT). PDT (665 ± 10 nm) with topical photosensitizer application was performed once a week. The PDT course consisted of 4 ± 2 sessions. After the therapy, complete remission was achieved in four patients (80%; mSWAT 95–100%) and partial remission in one patient (20%; mSWAT 63%). Thus, PDT proved to be an effective and safe method for treating CLH.

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About the authors

O. Yu. Olisova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
ORCID iD: 0000-0003-2482-1754

MD, PhD, DSc, Head of Department of Dermatology and Venereology

Russian Federation, Moscow, 119991

E. M. Anpilogova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID iD: 0000-0001-9478-5838

Department of Dermatology and Venerology

Russian Federation, Moscow, 119991


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Supplementary files

Supplementary Files
1. Fig. 1. Patient K., 70 years old (see table). Benign skin lymphoplasia after hirudotherapy. a - before treatment; b - after 4 sessions of photodynamic therapy.

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2. Fig. 2. Patient L., 71 years old (see table). Benign skin lymphoplasia, postscabious. a - before treatment; b - after 3 sessions of photodynamic therapy.

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3. Fig. 3. Clinical response in patients with benign skin lymphoplasia to photodynamic therapy (in%).

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