Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access


Erythroderma - the term used for the description intensive and usually widespread reddening of the skin which has arisen owing to activation of the previous inflammatory dermatosis. The aim is to study and compare clinical manifestations of various forms of an erythroderma and also to develop an algorithm of their diagnostics and therapy. We observed 133 patients with an erythroderma undergoing investigation and treatment on bases of dermatologic depatments: V.A. Rakhmanov Clinic of skin and veneral diseases I.M. Sechenov First Moscow State Medical University, Leningrad Regional centre of specialized types of a medical care, Skin-Venerologic Clinic of St. Petersburg and university clinic Bonn the period from 2001 to 2018. A prospective study was conducted at 51 patients, is retrospective - at 82 patients. From them were men - 83 persons and women - 50 people, whose average age was 49 years (in the range 26-85 years). The collecting of the anamnesis is carried out; clinical data are studied and for verification of the diagnosis are compared with results of a histological research. Clinical manifestations of all surveyed groups were similar. The most frequent symptoms were generalized reddening and a peeling of the skin, an itch of skin, different degree of expressiveness and a form of changes of nail plates, changes of palms and soles. Diagnosis on the basis of only clinical examination gave the chance to make the correct diagnosis in 77(58%), in comparison with the final diagnosis 112(84,1%) from 133 made on the basis of set of clinical, histological data and reaction to therapy. In particular, the diagnosis of a psoriatic erythroderma was made in 26(34,58%) from 133, an atopic eythroderma - 20(26,6%), the eythroderma caused by reception of drugs - 24(31,92%), an erythrodermic form of mycosis fungoides/Cezary syndrome - 7(9,31%) from 133 patients. The clinical diagnosis didn’t correspond to the final diagnosis in other 56(42%) from 133 patients. Thus, at diagnosis and definition of forms of an erythroderma important aspect is clinical examination and clinicopathologic correlation.

Full Text

Restricted Access

About the authors

O. Yu Olisova

I.M. Sechenov First Moscow State Medical University

119991, Moscow, Russian Federation

D. V Zaslavsky

St.Petersburg State Pediatric Medical University

194100, St.Petersburg, Russian Federation

A. A Sidikov

St.Petersburg State Pediatric Medical University

194100, St.Petersburg, Russian Federation

I. N Chuprov

North-Western State Medical University n.a I.I. Mechnikov

191015, St. Petersburg, Russian Federation

J. Wenzel

University Сlinic of Bonn

D 53105, Bonn, Germany

Ekaterina V. Grekova

I.M. Sechenov First Moscow State Medical University

graduate student of I.M. Sechenov First Moscow State Medical University, Moscow, 119991, Russian Federation 119991, Moscow, Russian Federation


  1. Rothe M.J, Bernstein M.L, Grant-Kels J.M. Life-threatening erythroderma: diagnosing and treating the “red man”. Clinics in Dermatology. 2005; 23(2): 206-17.
  2. Yang J.H, Choi S.J, Won C.H, Chang S, Lee M.W, Huh J.R, Lee K.H, Choi J.H, Moon K.C. Paraneoplastic erythroderma: an unusual manifestation of diffuse large B-cell lymphoma. Int. J. Dermatol. 2013; 52(9): 1149-51.
  3. Leong A.S, Cowled P.A, Zalewski P.D, Burry J.N, Meredith D.J, Forbes I.J. Erythroderma, an unusual manifestation of B cell lymphoma. Br. J. Dermatol. 1978; 99(1): 99-106.
  4. Chakraborty S. Lymphoma as a cause of exfoliative dermatitis. Indian J. Dermatol. 1983; 28(3): 121-3.
  5. Nishijima S. Papuloerythroderma associated with hepatocellular carcinoma. Br. J. Dermatol. 1998; 139(6): 1115-6.
  6. Axelrod J.H., Herbold D.R., Freel J.H., Palmer S.M. Exfoliative dermatitis: presenting sign of fallopian tube carcinoma. Obstet. Gynecol. 1988; 71(6, Pt 2): 1045-7.
  7. Deffer T.A., Overton-Keary P.P., Goette D.K. Erythroderma secondary to esophageal carcinoma. J. Am. Acad. Dermatol. 1985; 13(2): 311-3.
  8. Harper T.G., Latuska R.F., Sperling H.V. An unusual association between erythroderma and an occult gastric carcinoma. Am. J. Gastroenterol. 1984; 79(12): 921-3.
  9. Kameyama H., Shirai Y., Date K., Kuwabara A., Kurosaki R., Hatakeyama K. Gallbladder carcinoma presenting as exfoliative dermatitis (erythroderma). Int. J. Gastrointest. Cancer. 2005; 35(2): 153-5.
  10. Nousari H.C., Kimyai-Asadi A., Spegman D.J. Paraneoplastic dermatomyositis presenting as erythroderma. J. Am. Acad. Dermatol. 1998; 39(4): 653-4.
  11. Patrizi A., Pileri S., Rivano M.T., Di Lernia V. Malignant histiocytosis presenting as erythroderma. Int. J. Dermatol. 1990; 29(3): 214-6.
  12. Rosen T, Chappell R, Drucker C. Exfoliative dermatitis: Presenting sign of internal malignancy. Southern. Med. J. 1979; 72(6): 652-3.
  13. Олисова О.Ю., Теплюк Н.П., Плиева Л.Р., Ломоносов К.М. Эритродермическая форма болезни Девержи. Российский журнал кожных и венерических болезней. 2014; 17(1): 18-20
  14. Harris D.W., Spencer M.J., Tidman M.J. Papuloerythroderma-clinical and ultrastructural features. Clin. Exp. Dermatol. 1990; 15(2): 105-6.
  15. Ofuji S. Papuloerythroderma. J. Am. Acad. Dermatol. 1990; 22(4): 697.
  16. Lacour J.P., Perrin C., Ortonne J.P. Ofuji papuloerythroderma: A new European case. Dermatology. 1993; 186(3): 190-2.
  17. Заславский Д.В., Родионов А.Н., Чупров И.Н., Насыров Р.А., Егорова Ю.С., Сыдиков А.А. Эволюция взглядов на эритродермию. Российский журнал кожных и венерических болезней. 2017; 20(1): 10-4
  18. Shelley W.B, Shelley E.D. Shoreline nails: Sign of drug-induced erythroderma. Cutis. 1985; 35(3): 220-2.
  19. Sehgal V.N, Srivastava G, Sardana K. Erythroderma/exfoliative dermatitis: A synopsis. Int. J. Dermatol. 2004; 43(1): 39-47.
  20. Rubins A.Y, Hartmane I.V, Lielbriedis Y.M, Schwartz R.A. Therapeutic options for erythroderma. Cutis. 1992; 49(6): 424-6.
  21. Joly P., Tanasescu S., Wolkenstein P., Bocquet H., Gilbert D. Lichenoid erythrodermic bullous pemphigoid of the African patient. J. Am. Acad. Dermatol. 1998; 39(5, Pt 1): 691-7.
  22. Pierson J.C., Taylor J.S. Erythrodermic dermatomyositis. J. Am. Acad. Dermatol. 1993; 28(1): 136.
  23. Nousari H.C., Kimyai-Asadi A., Spegman D.J. Paraneoplastic dermatomyositis presenting as erythroderma. J. Am. Acad. Dermatol. 1998; 39(4, Pt 1): 653-4.
  24. Morar N., Dlova N., Gupta A.K., Naidoo D.K., Aboobaker J., Ramdial P.K. Erythroderma: A comparison between HIV positive and negative patients. Int. J. Dermatol. 1999; 38(12): 895-900.
  25. Родионов А.Н. Эритродермическая лимфома кожи. Л.: ВМедА; 1989
  26. Balasubramaniam P., Berth-Jones J. Erythroderma: 90% skin failure. Hosp. Med. 2004; 65(2): 100-2.
  27. Akhyani M., Ghodsi Z.S., Toosi S., Dabbaghian H. Erythroderma: A clinical study of 97 cases. BMC Dermatol. 2005; 5(1): 5.
  28. Botella-Estrada R., Sanmartin O., Oliver V., Febrer I., Aliaga A. Erythroderma: A clinicopathological study of 56 cases. Arch. Dermatol. 1994; 130(12): 1503-7.
  29. Hasan T., Jansen C.T. Erythroderma: A follow-up of fifty cases. J. Am. Acad. Dermatol. 1983; 8(6): 836-40.
  30. Leenutaphong V., Kulthanan K., Pohboon C., Suthipinittharn P., Sivayathorn A., Sunthonpalin P. Erythroderma in Thai patients. J. Med. Assoc. Thailand. 1999; 82(8): 743-8.
  31. Заславский Д.В., Чупров И.Н., Насыров Р.А., Сыдиков А.А., Максимова М.Д., Вензел Й., Татарская О.Б. Гистологические модели (паттерны) воспаления при эритродермии. Иммунопатология, аллергология, инфектология. 2016; 4: 65-73
  32. Toonstra J., Hezemans-Boer M., van Vloten W.A. Erythroderma: a clinical and follow-up study of 102 patients, with special emphasis on survival. J. Am. Acad. Dermatol. 1996; 35(1): 53-7.
  33. Vonderheid E.C., Bernengo M.G., Burg G., Duvic M., Heald P., Laroche L., Willemze R. Update on erythrodermic cutaneous T-cell lymphoma: report of the international society for cutaneous lymphomas. J. Am. Acad. Dermatol. 2002; 46(1): 95-106.
  34. Goldsmith L.A., Katz S.I., Gilchrest B.A., Paller A.S., Leffell D.J., Wolff K. Fitzpatrick’s Dermatology in General Medicine. New York: McGraw-Hill; 2007: 225-32.
  35. Rym B.M., Mourad M., Bechir Z., Dalenda E., Faika C., Iadh A.M. Erythroderma in adults: A report of 80 cases. Int. J. Dermatol. 2005; 44(9): 731-5.
  36. Kanwar A.J., Dhar S., Ghosh S. ”Nose sign” in dermatology. Dermatology. 1993; 187(4): 278.
  37. Agarwal S., Khullar R., Kalla G., Malhotra Y.K. Nose sign of exfoliative dermatitis: A possible mechanism. Arch. Dermatol. 1992; 128(5): 704.
  38. Jaffer A.N., Brodell R.T. Exfoliative dermatitis: Erythroderma can be a sign of a significant underlying disorder. Postgrad Med. 2005; 117(1): 49-51.



Abstract: 103

PDF (Russian): 1


Article Metrics

Metrics Loading ...


Copyright (c) 2018 Eco-Vector

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies