Photogallery. Metabolic dermatoses

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Abstract

Metabolic dermatoses are signs of some internal diseases, which makes it possible to identify them before clinical manifistation. Thus amyloidosis is often associated with Familial Mediterranean fever, and its timely diagnosis contributes to the detection of diseases such as medullary thyroid cancer, multiple myeloma, Waldenstrom macroglobulinemia and other monoclonal gammopathy, nephropathy, generalized sensorimotor polyneuropathy, dysfunction of the gastrointestinal tract, etc. Necrobiosis lipoidica is associated with diabetes mellitus, mucinosis ― with thyroid diseases, xanthomas ― with histiocytosis X, porphyria ― with liver disease, calcinosis ― with abnormality calcium metabolism.

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About the authors

Olga V. Grabovskaya

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: olgadoctor2013@yandex.ru
ORCID iD: 0000-0002-1231-1717

PhD, Associate Professor of the Department of skin and veneral diseases n.a. V.A. Rakhmanov

Russian Federation, Moscow

Nataliya P. Teplyuk

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: teplyukn@gmail.com
ORCID iD: 0000-0002-5800-4800

PhD, professor of Department of skin and veneral diseases n.a. V.A. Rakhmanov

Russian Federation, Moscow

Yuliya V. Kolesova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: kolesovamsmu@gmail.com
ORCID iD: 0000-0002-3617-2555

postgraduated student of Department of skin and veneral diseases n.a. V.A. Rakhmanov

Russian Federation, Moscow

References

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2. Fig. 1. Spotted amyloidosis of the skin (a grayish-brown spot occupying the upper back).

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3. Fig. 2. Calcinosis (Techlander’s syndrome). Nodes on the lateral surface of the thigh.

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4. Fig. 3. Xanthelasma (xanthomas of the eyelids).

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5. Fig. 4. Eruptive xanthomas can appear in decompensated diabetes mellitus and familial hyperlipidemia. Patients with eruptive xanthomas often show hyperlipidemia Ia, IIb, IV and V types, familial dysbetalipoproteinemia, familial hypercholesterolemia, but 50% of patients may have normal values.

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6. Fig. 5. Xanthomatosis as a manifestation of histiocytosis Х.

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7. Fig. 6. Myxedematous lichen (glossy lichenoid nodules of the color of unchanged skin, prone to fusion): а ― along the hairline; b ― along the hairline and behind the behind the ear area.

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8. Fig. 7. Pretibial myxedema (foci of a purple-bluish color with a bumpy shiny surface and a characteristic sign of “orange peel”). Generalized (diffuse) myxedema develops against the background of hypothyroidism (endemic goiter) with severe hormone deficiency (grade III), as well as with an increase in the production of pituitary thyroid-stimulating hormone, often after treatment of hyperthyroidism and disorders of the thyroid-pituitary relationship.

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9. Fig. 8. Lipoid necrobiosis, classical form (plaques with a shiny surface, irregular outlines, clear boundaries and a peripheral ridge). In patients with lipoid necrobiosis, regardless of the presence of endocrine pathology, changes in the hormonal regulation of carbohydrate metabolism were revealed: basal hyperinsulinemia (less often hypoinsulinemia), increased levels of insulin and glucagon in the blood.

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10. Fig. 9. Ulcerative form of lipoid necrobiosis.

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11. Fig. 10. Late cutaneous porphyria (erosion at the site of blisters on intact skin and scars on the back of the hands). Association with other diseases: diabetes mellitus (found in 25% with porphyria), hepatitis, cirrhosis of the liver.

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