Our decades of experience treating vitiligo with UVB therapy.
- Authors: Krotkova E.1, Olisova O.Y.2, Smirnov K.V.2, Al Momani M.2, Lomonosov K.M.2
-
Affiliations:
- I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
- I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
- Section: DERMATOLOGY
- Submitted: 19.01.2024
- Accepted: 19.05.2024
- Published: 19.05.2024
- URL: https://rjsvd.com/1560-9588/article/view/625814
- DOI: https://doi.org/10.17816/dv625814
- ID: 625814
Cite item
Abstract
Rationale: From the advent of modern phototherapy to the present day, this technique has been an important tool for the treatment of various skin diseases such as psoriasis, parapsoriasis, CRPS, scleroderma, atopic dermatitis, lymphomas, etc. One of the common dermatologic diseases where this technique is used as a "gold" standard is vitiligo. Despite the existence of a wide range of therapies for this disease, phototherapy remains the standard of care because of its proven efficacy and favorable side effect profile.
The aim is to study the efficacy of UVB-311 nm in the treatment of vitiligo, to assess adherence to therapy, as well as to analyze the reasons for discontinuation of phototherapy in order to optimize the future results of treatment.
Material and methods: 348 people suffering from progressive vitiligo were included in the study.
Results: An excellent (repigmentation > 75%) response was observed in 30% of patients. In 32% of patients repigmentation was between 51% and 75%, 23% of patients responded to treatment with repigmentation between 25%-50% of foci.15% of patients completed the course of treatment due to lack of response and repigmentation less than 25% after the first 30 treatments. Only 68% of patients completed the full course of narrow-band UVB-311 nm therapy, the average number of treatments was 49.
Conclusion: The study demonstrated good clinical efficacy of UVB-311 nm phototherapy. However, a number of interventions are needed to optimize treatment results and improve treatment adherence.
Full Text
About the authors
Elizaveta Krotkova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Author for correspondence.
Email: elise1197@mail.ru
ORCID iD: 0000-0001-7343-7252
врач-ординатор отделения клиники кожных и венерических болезней им. В.А. Рахманова
Russian FederationOlga Yu. Olisova
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Email: olisovaolga@mail.ru
ORCID iD: 0000-0003-2482-1754
SPIN-code: 2500-7989
MD, Dr. Sci. (Med.), Professor, Corresponding member of the Russian Academy of Sciences
Russian Federation, MoscowKonstantin V. Smirnov
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Email: puva3@mail.ru
ORCID iD: 0000-0001-7660-7958
SPIN-code: 2054-1086
MD, Cand. Sci. (Med.)
Russian Federation, MoscowMohammed Al Momani
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Email: Almomanimohamd65@gmail.com
ORCID iD: 0009-0009-9009-2239
Russian Federation, Moscow
Konstantin M. Lomonosov
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Email: lamclinic@yandex.ru
ORCID iD: 0000-0002-4580-6193
SPIN-code: 4784-9730
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowReferences
- Bibliography
- Wolkerstorfer A. Evidence for efficacy of home-based narrowband ultraviolet B therapy // Br J Dermatol. 2021 May;184(5):790. doi: 10.1111/bjd.19749. Epub 2021 Feb 1. PMID: 33523459; PMCID: PMC8247848.
- Rathod D.G., Muneer H., Masood S. Phototherapy. 2023 Feb 16 // Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 33085287.
- Bouceiro Mendes R., Alpalhão M., Filipe P. UVB phototherapy in the treatment of vitiligo: State of the art and clinical perspectives // Photodermatol Photoimmunol Photomed. 2022 May;38(3):215-223. doi: 10.1111/phpp.12740. Epub 2021 Oct 16. PMID: 34626483.
- Mohammad T.F., Silpa-Archa N., Griffith J.L., et al.Home phototherapy in vitiligo // Photodermatol Photoimmunol Photomed. 2017 Sep;33(5):241-252. doi: 10.1111/phpp.12321. Epub 2017 Jul 14. PMID: 28620923.
- Bae J.M., Jung H.M., Hong B.Y., et al. Phototherapy for Vitiligo: A Systematic Review and Meta-analysis // JAMA Dermatol. 2017 Jul 1;153(7):666-674. doi: 10.1001/jamadermatol.2017.0002. PMID: 28355423; PMCID: PMC5817459.
- Smith M.P., Ly K., Thibodeaux Q., et al. Home phototherapy for patients with vitiligo: challenges and solutions // Clin Cosmet Investig Dermatol. 2019 Jun 28;12:451-459. doi: 10.2147/CCID.S185798. PMID: 31388308; PMCID: PMC6607222.
- Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the International Vitiligo Task Force Part 1: towards a new management algorithm. J Eur Acad Dermatol Venereol. 2023 Nov;37(11):2173-2184. doi: 10.1111/jdv.19451. Epub 2023 Sep 25. PMID: 37746876.
- Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the international Vitiligo Task Force-Part 2: Specific treatment recommendations. J Eur Acad Dermatol Venereol. 2023 Nov;37(11):2185-2195. doi: 10.1111/jdv.19450. Epub 2023 Sep 15. PMID: 37715487.
- Federal clinical guidelines for the management of vitiligo patients, 2015, 2015
- Branisteanu D.E., Dirzu D.S., Toader M.P., et al.Phototherapy in dermatological maladies (Review) // Exp Ther Med. 2022 Apr;23(4):259. doi: 10.3892/etm.2022.11184. Epub 2022 Feb 3. PMID: 35251325; PMCID: PMC8892600.
- Pinson I.Y, Olisova O.Y, Bashlakova K.A, et al. On the question of the treatment of vitiligo // Russian Journal of Skin and Venereal Diseases. - 2016. - Vol. 19. - N. 2. - P. 102-102. doi: 10.17816/dv37146
- Ashraf A.Z., Azurdia R.M., Cohen S.N. The effectiveness of home-based phototherapy for vitiligo: A systematic review of randomised controlled trials // Photodermatol Photoimmunol Photomed. 2022 Sep;38(5):409-417. doi: 10.1111/phpp.12766. Epub 2022 Jan 25. PMID: 34967477.
- Jacob J., Pona A., Cline A., Feldman S. Home UV Phototherapy // Dermatol Clin. 2020 Jan;38(1):109-126. doi: 10.1016/j.det.2019.09.001. PMID: 31753183.
- Lomonosov K.M, Gereykhanova L.G. Vitiligo treatment algorithm // Russian Journal of Skin and Venereal Diseases. - 2016. - Vol. 19. - N. 3. - P. 167-169. doi: 10.18821/1560-9588-2016-19-3-167-169
- Khojah H.M.J., Alharbi A.G., Alshaeri A.A., et al. Impact of narrow-band ultraviolet B radiation therapy on the quality of life of patients with vitiligo // J Taibah Univ Med Sci. 2021 Jun 12;16(6):843-848. doi: 10.1016/j.jtumed.2021.04.012. PMID: 34899128; PMCID: PMC8626815.
- Bhatia S., Khaitan B.K., Gupta V. et al. Efficacy of NB-UVB in Progressive Versus Non-Progressive Non-Segmental Vitiligo: A Prospective Comparative Study // Indian Dermatol Online J. 2021 Aug 2;12(5):701-705. doi: 10.4103/idoj.IDOJ_40_21. PMID: 34667756; PMCID: PMC8456245.
- References
- Wolkerstorfer A. Evidence for efficacy of home-based narrowband ultraviolet B therapy. Br J Dermatol. 2021 May;184(5):790. doi: 10.1111/bjd.19749. Epub 2021 Feb 1. PMID: 33523459; PMCID: PMC8247848.
- Rathod DG, Muneer H, Masood S. Phototherapy. 2023 Feb 16. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 33085287.
- Bouceiro Mendes R, Alpalhão M, Filipe P. UVB phototherapy in the treatment of vitiligo: State of the art and clinical perspectives. Photodermatol Photoimmunol Photomed. 2022 May;38(3):215-223. doi: 10.1111/phpp.12740. Epub 2021 Oct 16. PMID: 34626483.
- Mohammad TF, Silpa-Archa N, Griffith JL, et al. Home phototherapy in vitiligo. Photodermatol Photoimmunol Photomed. 2017 Sep;33(5):241-252. doi: 10.1111/phpp.12321. Epub 2017 Jul 14. PMID: 28620923.
- Bae JM, Jung HM, Hong BY, et al. Phototherapy for Vitiligo: A Systematic Review and Meta-analysis.JAMA Dermatol. 2017 Jul 1;153(7):666-674. doi: 10.1001/jamadermatol.2017.0002. PMID: 28355423; PMCID: PMC5817459.
- Smith MP, Ly K, Thibodeaux Q, et al. Home phototherapy for patients with vitiligo: challenges and solutions.Clin Cosmet Investig Dermatol. 2019 Jun 28;12:451-459. doi: 10.2147/CCID.S185798. PMID: 31388308; PMCID: PMC6607222.
- Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the International Vitiligo Task Force Part 1: towards a new management algorithm. J Eur Acad Dermatol Venereol. 2023 Nov;37(11):2173-2184. doi: 10.1111/jdv.19451. Epub 2023 Sep 25. PMID: 37746876.
- Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the international Vitiligo Task Force-Part 2: Specific treatment recommendations. J Eur Acad Dermatol Venereol. 2023 Nov;37(11):2185-2195. doi: 10.1111/jdv.19450. Epub 2023 Sep 15. PMID: 37715487.
- Federal clinical guidelines for the management of vitiligo patients, 2015, 2015
- Branisteanu DE, Dirzu DS, Toader MP, et al.Phototherapy in dermatological maladies (Review).Exp Ther Med. 2022 Apr;23(4):259. doi: 10.3892/etm.2022.11184. Epub 2022 Feb 3. PMID: 35251325; PMCID: PMC8892600.
- Pinson IY, Olisova OY, Bashlakova KA, et al. On the question of the treatment of vitiligo. Russian Journal of Skin and Venereal Diseases. - 2016. - Vol. 19. - N. 2. - P. 102-102. doi: 10.17816/dv37146
- Ashraf AZ, Azurdia RM, Cohen SN. The effectiveness of home-based phototherapy for vitiligo: A systematic review of randomised controlled trials. Photodermatol Photoimmunol Photomed. 2022 Sep;38(5):409-417. doi: 10.1111/phpp.12766. Epub 2022 Jan 25. PMID: 34967477.
- Jacob J, Pona A, Cline A, Feldman S. Home UV Phototherapy. Dermatol Clin. 2020 Jan;38(1):109-126. doi: 10.1016/j.det.2019.09.001. PMID: 31753183.
- Lomonosov KM, Gereykhanova LG. Vitiligo treatment algorithm. Russian Journal of Skin and Venereal Diseases. - 2016. - Vol. 19. - N. 3. - P. 167-169. doi: 10.18821/1560-9588-2016-19-3-167-169
- Khojah HMJ, Alharbi AG, Alshaeri AA, et al. Impact of narrow-band ultraviolet B radiation therapy on the quality of life of patients with vitiligo. J Taibah Univ Med Sci. 2021 Jun 12;16(6):843-848. doi: 10.1016/j.jtumed.2021.04.012. PMID: 34899128; PMCID: PMC8626815.
- Bhatia S, Khaitan BK, Gupta V et al. Efficacy of NB-UVB in Progressive Versus Non-Progressive Non-Segmental Vitiligo: A Prospective Comparative Study. Indian Dermatol Online J. 2021 Aug 2;12(5):701-705. doi: 10.4103/idoj.IDOJ_40_21. PMID: 34667756; PMCID: PMC8456245.