GENDER SPECIFIC CHANGES IN MOUSE BLOOD ESTRERASE PROFILE AT THE ACUTE INTOXICATION BY 2-(О-CRESYL)-4Н-1,3,2-BENZODIOXAPHOSPHORIN-2-OXIDE

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Abstract

A comparative investigation of the esterase profiles of blood of mice of both genders exposed to various doses of 2-(o-crezyl)-4H-1,3,2-benzodioxaphosphorin-2-oxide (CBDP) was made an hour after its percutaneous injection to animals. A lesser amount of esterase in males blood made them more susceptible to CBDP action as compared to females. It was shown that CBDP equally inhibits the activity of carboxyl esterase and butyryl choline esterase in blood serum of both male and female mice. Statistically significant differences in inhibition degree of enzymes between males and females were found out and therefore it is not recommended to use mixed groups of animals when performing testing of serine esterase inhibitors.

About the authors

D. S. Prokofieva

Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency of Russia

Author for correspondence.
Email: darija-p1@yandex.ru
188663, Saint Petersburg Russian Federation

V. I. Shmurak

Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency of Russia

Email: vladimir.shmurak@gmail.com
188663, Saint Petersburg Russian Federation

E. A. Bodryakova

Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency of Russia

Email: bodalena@yandex.ru
188663, Saint Petersburg Russian Federation

N. G. Voitenko

Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency of Russia

Email: ngvoitenko@gmail.com
188663, Saint Petersburg Russian Federation

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Copyright (c) 2017 Prokofieva D.S., Shmurak V.I., Bodryakova E.A., Voitenko N.G.


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