Non-traumatic Limping in the Child: A Pediatric Rheumatologist Perspective on Etiology, Clinical Evaluation, Laboratory Diagnosis, and Diagnostic Algorithms using Musculoskeletal Ultrasound (MSUS)


Cite item

Full Text

Abstract

Limping refers to an asymmetrical gait that deviates from the typical gait pattern ex- pected for a child of a certain age. In most children, limping is caused by a mild, self-limiting event, such as a contusion, strain, or sprain. However, a child's limping is always a pathological finding that poses a particular diagnostic challenge and necessitates a thorough assessment. The pediatrician must weigh a wide range of acute and chronic potential causes of a non-traumatic limp, including infection, neoplasia, and chronic inflammatory disorders. A thorough history and clinical examina- tion will help us arrive at the correct diagnosis. Understanding the typical gait is essential to recog- nizing and correctly interpreting the disordered one. The examination of child limping involves us- ing a variety of diagnostic methods. Efficient and cost-effective diagnosis and treatment of the un- derlying condition requires a systematic approach. This review provides the pediatric rheumatolo- gist perspective and approach for evaluating non-traumatic limp in children, with a focus on the use of point-of-care (PoC) musculoskeletal ultrasound (MSUS) as a crucial tool in daily practice.

About the authors

Miroslav Harjacek

Department of Pediatrics, United Arab Emirates University

Author for correspondence.
Email: info@benthamscience.net

References

  1. Smith E, Anderson M, Foster H. The child with a limp: A symptom and not a diagnosis. Arch Dis Child Educ Pract Ed 2012; 97(5): 185-93. doi: 10.1136/archdischild-2011-301245 PMID: 22822079
  2. De Inocencio J. Epidemiology of musculoskeletal pain in primary care. Arch Dis Child 2004; 89(5): 431-4. doi: 10.1136/adc.2003.028860 PMID: 15102634
  3. Vos T, Allen C, Arora M, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016; 388(10053): 1545-602. doi: 10.1016/S0140-6736(16)31678-6 PMID: 27733282
  4. Herman MJ, Martinek M. The limping child. Pediatr Rev 2015; 36(5): 184-97. doi: 10.1542/pir.36.5.184 PMID: 25934907
  5. Tse SML, Laxer RM. Approach to acute limb pain in childhood. Pediatr Rev 2006; 27(5): 170-80. doi: 10.1542/pir.27.5.170 PMID: 16651274
  6. Dominici N, Ivanenko YP, Cappellini G, Zampagni ML, Lacquaniti F. Kinematic strategies in newly walking toddlers stepping over differ-ent support surfaces. J Neurophysiol 2010; 103(3): 1673-84. doi: 10.1152/jn.00945.2009 PMID: 20089810
  7. Ivanenko YP, Dominici N, Lacquaniti F. Development of independent walking in toddlers. Exerc Sport Sci Rev 2007; 35(2): 67-73. doi: 10.1249/JES.0b013e31803eafa8 PMID: 17417053
  8. Gibson ME, Stork N. Gait Disorders. Prim Care 2021; 48(3): 395-415. doi: 10.1016/j.pop.2021.04.004 PMID: 34311847
  9. Beck RJ, Andriacchi TP, Kuo KN, Fermier RW, Galante JO. Changes in the gait patterns of growing children. J Bone Joint Surg Am 1981; 63(9): 1452-7. doi: 10.2106/00004623-198163090-00012 PMID: 7320036
  10. Raja H, Khan SA, Waheed A. The limping child - when to worry and when to refer: A GP’s guide. Br J Gen Pract 2020; 70(698): 467. doi: 10.3399/bjgp20X712565 PMID: 32855147
  11. Wassmer E, Wright E, Rideout S, Whitehouse WP. Idiopathic gait disorder among in-patients with acquired gait disorders admitted to a children’s hospital. Pediatr Rehabil 2002; 5(1): 21-8. doi: 10.1080/1363849021000007060 PMID: 12396848
  12. Vezzetti R, Bordoni B. Antalgic Gait InChildren. Treasure Island: StatPearls Publishing 2022.
  13. Lázaro Carreño MI, Fraile Currius R, García Clemente A. Non-traumatic limping in paediatric emergencies: Epidemiology, evaluation and results. Rev Esp Cir Ortop Traumatol 2018; 62(2): 127-33. doi: 10.1016/j.recot.2017.10.004
  14. Švehlík M, Kraus T, Steinwender G, Zwick EB, Linhart WE. Pathological gait in children with Legg-Calvé-Perthes disease and proposal for gait modification to decrease the hip joint loading. Int Orthop 2012; 36(6): 1235-41. doi: 10.1007/s00264-011-1416-2 PMID: 22134707
  15. Shah AP, Indra S, Kannikeshwaran N, Hartwig E, Kamat D. Diagnostic Approach to Limp in Children Pediatr Ann 2015; 44(12): 548-56. , 552-554, 556. doi: 10.3928/00904481-20151112-01 PMID: 26678234
  16. Adamson J, Waterfield T. Fifteen-minute consultation: The limping child. Arch Dis Child Educ Pract Ed 2020; 105(3): 137-41. doi: 10.1136/archdischild-2018-315905 PMID: 31255998
  17. Siegel KL, Kepple TM, Stanhope SJ. A case study of gait compensations for hip muscle weakness in idiopathic inflammatory myopathy. Clin Biomech 2007; 22(3): 319-26. doi: 10.1016/j.clinbiomech.2006.11.002 PMID: 17187908
  18. Achar S, Yamanaka J. Apophysitis and osteochondrosis: Common causes of pain in growing bones. Am Fam Physician 2019; 99(10): 610-8. PMID: 31083875
  19. Arnold A, Thigpen CA, Beattie PF, Kissenberth MJ, Shanley E. Overuse physeal injuries in youth athletes. Sports Health 2017; 9(2): 139-47. doi: 10.1177/1941738117690847 PMID: 28165873
  20. Ladenhauf HN, Seitlinger G, Green DW. Osgood-Schlatter disease: A 2020 update of a common knee condition in children. Curr Opin Pediatr 2020; 32(1): 107-12. doi: 10.1097/MOP.0000000000000842 PMID: 31714260
  21. Fares MY, Salhab HA, Khachfe HH, Fares J, Haidar R, Musharrafieh U. Sever’s disease of the pediatric population: Clinical, pathologic, and therapeutic considerations. Clin Med Res 2021; 19(3): 132-7. doi: 10.3121/cmr.2021.1639 PMID: 34531270
  22. Young SW, Safran MR. Greater trochanter apophysitis in the adolescent athlete. Clin J Sport Med 2015; 25(3): e57-8. doi: 10.1097/JSM.0000000000000127 PMID: 24942622
  23. Rodríguez-Olivas AO, Hernández-Zamora E, Reyes-Maldonado E. Legg-Calvé-Perthes disease overview. Orphanet J Rare Dis 2022; 17(1): 125. doi: 10.1186/s13023-022-02275-z PMID: 35292045
  24. Heesakkers N, van Kempen R, Feith R, Hendriks J, Schreurs W. The long-term prognosis of Legg-Calvé-Perthes disease: A historical pro-spective study with a median follow-up of forty one years. Int Orthop 2015; 39(5): 859-63. doi: 10.1007/s00264-014-2589-2 PMID: 25408489
  25. Jandl NM, Schmidt T, Schulz M, Rüther W, Stuecker MHF. MRI and sonography in Legg-Calvé-Perthes disease: Clinical relevance of containment and influence on treatment. J Child Orthop 2018; 12(5): 472-9. doi: 10.1302/1863-2548.12.180033 PMID: 30294371
  26. Li H, Zhang Z, Li C, et al. Computer-assisted design model to evaluate the outcome of combined osteotomies in Legg-Calvé-Perthes dis-ease. Front Pediatr 2022; 10: 920840. doi: 10.3389/fped.2022.920840 PMID: 36003490
  27. Benenson I, Porter S. Sickle Cell Disease. Orthop Nurs 2018; 37(4): 221-7. doi: 10.1097/NOR.0000000000000464 PMID: 30028422
  28. Aprato A, Conti A, Bertolo F, Massè A. Slipped capital femoral epiphysis: Current management strategies. Orthop Res Rev 2019; 11: 47-54. doi: 10.2147/ORR.S166735 PMID: 31040725
  29. Abosalem AA, Sakr SAH, Mesregah MK, Zayda AI. Mid-term results of subcapital realignment of chronic slipped capital femoral epiphy-sis using surgical hip dislocation: A prospective case series. J Orthop Traumatol 2022; 23(1): 57. doi: 10.1186/s10195-022-00676-1 PMID: 36484908
  30. Krul M, van der Wouden JC, Schellevis FG, van Suijlekom-Smit LWA, Koes BW. Acute non-traumatic hip pathology in children: Inci-dence and presentation in family practice. Fam Pract 2010; 27(2): 166-70. doi: 10.1093/fampra/cmp092 PMID: 20026553
  31. Taekema HC, Landham PR, Maconochie I. Towards evidence based medicine for paediatricians. Distinguishing between transient synovi-tis and septic arthritis in the limping child: How useful are clinical prediction tools? Arch Dis Child 2009; 94(2): 167-8. doi: 10.1136/adc.2008.152264 PMID: 19158141
  32. Syed R. Evaluating the limping child: A rheumatology perspective. Mo Med 2016; 113(2): 131-5. PMID: 27311224
  33. Uziel Y, Butbul-Aviel Y, Barash J, et al. Recurrent transient synovitis of the hip in childhood. Longterm outcome among 39 patients. J Rheumatol 2006; 33(4): 810-1. PMID: 16583482
  34. de Borja C, Watkins R, Woolridge T. Common ultrasound applications for pediatric musculoskeletal conditions. Curr Rev Musculoskelet Med 2022; 15(6): 447-55. doi: 10.1007/s12178-022-09788-x PMID: 35932426
  35. Donders CM, Spaans AJ, van Wering H, van Bergen CJA. Developments in diagnosis and treatment of paediatric septic arthritis. World J Orthop 2022; 13(2): 122-30. doi: 10.5312/wjo.v13.i2.122 PMID: 35317401
  36. Tu J, Gowdie P, Cassar J, Craig S. Test characteristics of history, examination and investigations in the evaluation for septic arthritis in the child presenting with acute non-traumatic limp. A systematic review. BMJ Open 2020; 10(12): e038088. doi: 10.1136/bmjopen-2020-038088 PMID: 33380476
  37. Thomas CS, Schiffman CJ, Faino A, Bompadre V, Schmale GA. Diagnostic criteria for the painful swollen pediatric knee: Distinguishing septic arthritis from aseptic effusion in a non-lyme endemic area. Front Surg 2021; 8: 740285. doi: 10.3389/fsurg.2021.740285 PMID: 34790694
  38. Nord KD, Dore DD, Deeney VF, et al. Evaluation of treatment modalities for septic arthritis with histological grading and analysis of lev-els of uronic acid, neutral protease, and interleukin-1. J Bone Joint Surg Am 1995; 77(2): 258-65. doi: 10.2106/00004623-199502000-00013 PMID: 7844133
  39. Wong M, Williams N, Cooper C. Systematic review of kingella kingae musculoskeletal infection in children: Epidemiology, impact and management strategies. Pediatric Health Med Ther 2020; 11: 73-84. doi: 10.2147/PHMT.S217475
  40. Dong Y, Glaser K, Speer CP. New Threats from an Old Foe: Methicillin-Resistant Staphylococcus aureus Infections in Neonates. Neonatology 2018; 114(2): 127-34. doi: 10.1159/000488582 PMID: 29804104
  41. Nickel N, Brooks S, Mize C, Messina A. Reducing Staphylococcus aureus infections in the neonatal intensive care unit. J Perinatol 2022; 42(11): 1540-5. doi: 10.1038/s41372-022-01407-4 PMID: 35487977
  42. Al Farii H, Zhou S, Albers A. Management of osteomyelitis in sickle cell disease: Review article. J Am Acad Orthop Surg Glob Res Rev 2020; 4(9): e20.00002. doi: 10.5435/JAAOSGlobal-D-20-00002
  43. Kocher MS, Mandiga R, Zurakowski D, Barnewolt C, Kasser JR. Validation of a clinical prediction rule for the differentiation between septic arthritis and transient synovitis of the hip in children. J Bone Joint Surg Am 2004; 86(8): 1629-35. doi: 10.2106/00004623-200408000-00005 PMID: 15292409
  44. Hunter S, Kennedy J, Baker JF. External validation of an algorithm to predict adjacent musculoskeletal infection in pediatric patients with septic arthritis. J Pediatr Orthop 2020; 40(10): e999-e1004. doi: 10.1097/BPO.0000000000001618 PMID: 32740178
  45. Gigante A, Coppa V, Marinelli M, Giampaolini N, Falcioni D, Specchia N. Acute osteomyelitis and septic arthritis in children: A systematic review of systematic reviews. Eur Rev Med Pharmacol Sci 2019; 23(2) (Suppl.): 145-58. doi: 10.26355/eurrev_201904_17484 PMID: 30977881
  46. Özkan EA, Göret CC, Özdemir ZT, et al. Pattern of primary tumors and tumor-like lesions of bone in children: Retrospective survey of biopsy results. Int J Clin Exp Pathol 2015; 8(9): 11543-8. PMID: 26617888
  47. Parmar R, Wadia F, Yassa R, Zenios M. Neuroblastoma. J Pediatr Orthop 2013; 33(4): e45-51. doi: 10.1097/BPO.0b013e318279c636 PMID: 23653041
  48. Gkoudina A, Gekas C, Polydorides M, Graikos G, Papakonstantinou E, Saloupis P. Pediatric leukemia from an orthopedic perspective: A case of acute lymphoblastic leukemia initially managed as septic hip with osteomyelitis. Cureus 2022; 14(4): e24103. doi: 10.7759/cureus.24103 PMID: 35573545
  49. Mongini T. Diagnostic algorithm and case conundrums: Patients presenting with proximal muscle weakness. BMC Musculoskelet Disord 2013; 14(S2) (Suppl. 2): O4. doi: 10.1186/1471-2474-14-S2-O4
  50. Cancarini P, Nozawa T, Whitney K, et al. The clinical features of juvenile dermatomyositis: A single-centre inception cohort. Semin Arthritis Rheum 2022; 57: 152104. doi: 10.1016/j.semarthrit.2022.152104 PMID: 36183479
  51. Gorczyca D, Iwańczyk P, Staś K, Postępski J. Knee pain as a reason for referral to a paediatric rheumatologist: A retrospective study. J Paediatr Child Health 2023; 59(3): 439-44. doi: 10.1111/jpc.16309 PMID: 36627832
  52. Wallny T, Brackmann HH, Seuser A, Diedrich O, Kraft CN. Haemophilic arthropathy of the hip in children - prognosis and long-term follow-up. Haemophilia 2003; 9(2): 197-201. doi: 10.1046/j.1365-2516.2003.00728.x PMID: 12614372
  53. Bakeer N, Dover S, Babyn P, et al. Musculoskeletal ultrasound in hemophilia: Results and recommendations from a global survey and consensus meeting. Res Pract Thromb Haemost 2021; 5(5): e12531. doi: 10.1002/rth2.12531 PMID: 34268464
  54. Merlet AN, Chatel B, Hourdé C, et al. How sickle cell disease impairs skeletal muscle function: Implications in daily life. Med Sci Sports Exerc 2019; 51(1): 4-11. doi: 10.1249/MSS.0000000000001757 PMID: 30095751
  55. Millan J, Karrs J, Helou M, Dunbar EE. The case of an adolescent male with sickle cell disease and atypical leg pain. Clin Pediatr 2020; 59(11): 1025-7. doi: 10.1177/0009922820920020 PMID: 32456455
  56. Iversen PO, Hankin A, Horn J, Pedersen TH, Borgersen R, Frøen HM. Deep compartment syndrome without myonecrosis: A case report on a rare complication of sickle cell disease. Cureus 2022; 14(9): e29164. doi: 10.7759/cureus.29164 PMID: 36258983
  57. Cochrane E, Young S, Shariff Z. Acute compartment syndrome in a patient with sickle cell disease. Ann R Coll Surg Engl 2020; 102(9): e1-2. doi: 10.1308/rcsann.2020.0160 PMID: 32777927
  58. Weiss PF. Evaluation and treatment of enthesitis-related arthritis. Curr Med Lit Rheumatol 2013; 32(2): 33-41. PMID: 24403667
  59. Malek S, Reinhold EJ, Pearce GS. The Beighton Score as a measure of generalised joint hypermobility. Rheumatol Int 2021; 41(10): 1707-16. doi: 10.1007/s00296-021-04832-4 PMID: 33738549
  60. van Leeuwen GJ, de Schepper EIT, Rathleff MS, Bindels PJE, Bierma-Zeinstra SMA, van Middelkoop M. Incidence and management of Osgood-Schlatter disease in general practice: Retrospective cohort study. Br J Gen Pract 2022; 72(717): e301-6. doi: 10.3399/BJGP.2021.0386 PMID: 34990396
  61. Foster HE, Jandial S. pGALS - paediatric gait arms legs and spine: A simple examination of the musculoskeletal system. Pediatr Rheumatol Online J 2013; 11(1): 44. doi: 10.1186/1546-0096-11-44 PMID: 24219838
  62. Foster H, Kay L, May C, Rapley T. Pediatric regional examination of the musculoskeletal system: A practice- and consensus-based ap-proach. Arthritis Care Res 2011; 63(11): 1503-10. doi: 10.1002/acr.20569 PMID: 21954040
  63. Sproston NR, Ashworth JJ. Role of C-reactive protein at sites of inflammation and infection. Front Immunol 2018; 9: 754. doi: 10.3389/fimmu.2018.00754 PMID: 29706967
  64. Singhal R, Perry DC, Khan FN, et al. The use of CRP within a clinical prediction algorithm for the differentiation of septic arthritis and transient synovitis in children. J Bone Joint Surg Br 2011; 93-B(11): 1556-61. doi: 10.1302/0301-620X.93B11.26857 PMID: 22058311
  65. Saltzman HM, Hobson WL, Stern SM. Interpreting rheumatology laboratory tests. Pediatr Rev 2022; 43(5): 294-6. doi: 10.1542/pir.2021-004981
  66. Lamot L, Miler M, Vukojević R, et al. The increased levels of fecal calprotectin in children with active enthesitis related arthritis and mri signs of sacroiliitis: The results of a single center cross-sectional exploratory study in juvenile idiopathic arthritis patients. Front Med 2021; 8: 650619. doi: 10.3389/fmed.2021.650619 PMID: 33763437
  67. Jaramillo D, Dormans JP, Delgado J, Laor T, St Geme JW III. Hematogenous osteomyelitis in infants and children: Imaging of a changing disease. Radiology 2017; 283(3): 629-43. doi: 10.1148/radiol.2017151929 PMID: 28514223
  68. DiPoce J, Jbara ME, Brenner AI. Pediatric osteomyelitis: A scintigraphic case-based review. Radiographics 2012; 32(3): 865-78. doi: 10.1148/rg.323115110 PMID: 22582364
  69. Lee YJ, Sadigh S, Mankad K, Kapse N, Rajeswaran G. The imaging of osteomyelitis. Quant Imaging Med Surg 2016; 6(2): 184-98. doi: 10.21037/qims.2016.04.01 PMID: 27190771
  70. Riquelme VS, García CB. Imaging studies in early diagnosis of childhood leukemia. Rev Chil Radiol 2012; 18(1): 24-9.
  71. Salom M, Chiari C, Alessandri JMG, Willegger M, Windhager R, Sanpera I. Diagnosis and staging of malignant bone tumours in children: What is due and what is new? J Child Orthop 2021; 15(4): 312-21. doi: 10.1302/1863-2548.15.210107 PMID: 34476020
  72. Hemke R, Kuijpers TW, Nusman CM, et al. Contrast-enhanced MRI features in the early diagnosis of Juvenile Idiopathic Arthritis. Eur Radiol 2015; 25(11): 3222-9. doi: 10.1007/s00330-015-3752-x PMID: 26002127
  73. Malartre S, Bachasson D, Mercy G, et al. MRI and muscle imaging for idiopathic inflammatory myopathies. Brain Pathol 2021; 31(3): e12954. doi: 10.1111/bpa.12954 PMID: 34043260
  74. Malattia C, Tolend M, Mazzoni M, et al. Current status of MR imaging of juvenile idiopathic arthritis. Best Pract Res Clin Rheumatol 2020; 34(6): 101629. doi: 10.1016/j.berh.2020.101629 PMID: 33281052
  75. Huang Z, Gao B, Chen H, et al. An efficacy analysis of whole-body magnetic resonance imaging in the diagnosis and follow-up of poly-myositis and dermatomyositis. PLoS One 2017; 12(7): e0181069. doi: 10.1371/journal.pone.0181069 PMID: 28715432
  76. Lamot M, Lamot L, Vidovic M, Paleka Bosak E, Rados I, Harjacek M. Thermal point of care diagnostic tool for measurement of joint inflammation. Pediatric Rheumatology 2017; 15 (Suppl. 1): 53.
  77. Lasanen R, Piippo-Savolainen E, Remes-Pakarinen T, et al. Thermal imaging in screening of joint inflammation and rheumatoid arthritis in children. Physiol Meas 2015; 36(2): 273-82. doi: 10.1088/0967-3334/36/2/273 PMID: 25582734
  78. Nwaizu H, Saatchi R, Hawley DP, Ward O. Thermal and visual imaging to assist with juvenile idiopathic arthritis examination of the knees. Technologies 2020; 8(2): 30. doi: 10.3390/technologies8020030
  79. Balay-Dustrude E, Bhide N, Scheck J, et al. Validating within-limb calibrated algorithm using a smartphone attached infrared thermal cam-era for detection of arthritis in children. J Therm Biol 2023; 111: 103437. doi: 10.1016/j.jtherbio.2022.103437 PMID: 36585071
  80. Tok F, Demirkaya E, Özçakar L. Musculoskeletal ultrasound in pediatric rheumatology. Pediatr Rheumatol Online J 2011; 9(1): 25. doi: 10.1186/1546-0096-9-25 PMID: 21910870
  81. Vega-Fernandez P, Ting TV, Pratt L, Bacha CM, Oberle EJ. Ultrasonography in pediatric rheumatology. Rheum Dis Clin North Am 2022; 48(1): 217-31. doi: 10.1016/j.rdc.2021.09.009 PMID: 34798948
  82. Quesada-Masachs E, Lopez-Corbeto M, Moreno-Ruzafa E. Ultrasound in pediatric rheumatology: Highlighting the differences with adults. Eur J Rheumatol 2022. doi: 10.5152/eujrheum.2022.21119 PMID: 35943455
  83. Poboży T, Konarski W, Piotrowska-Lis K, Domańska J, Poboży K, Kielar M. Basic differences and most common findings in ultrasound examinations of musculoskeletal system in children: A narrative literature review. Healthcare 2022; 10(10): 2010. doi: 10.3390/healthcare10102010 PMID: 36292459
  84. Gau CC, Yao TC, Gan ST, et al. Age, gender, height and weight in relation to joint cartilage thickness among school-aged children from ultrasonographic measurement. Pediatr Rheumatol Online J 2021; 19(1): 71. doi: 10.1186/s12969-021-00554-w PMID: 33980256
  85. Collado P, Vojinovic J, Nieto JC, et al. Toward standardized musculoskeletal ultrasound in pediatric rheumatology: Normal age-related ultrasound findings. Arthritis Care Res 2016; 68(3): 348-56. doi: 10.1002/acr.22670 PMID: 26216627
  86. Windschall D, Collado P, Vojinovic J, et al. Age‐related vascularization and ossification of joints in children: An international pilot study to test multiobserver ultrasound reliability. Arthritis Care Res 2020; 72(4): 498-506. doi: 10.1002/acr.23335 PMID: 28777893
  87. Vidovic M, Lamot L, Lamot M, Harjacek M. Intraarticular infliximab therapy in patients with juvenile idiopathic arthritis: The role of musculoskeletal ultrasound and disease activity scores in monitoring therapy response. Clin Exp Rheumatol 2018; 36(4): 676-82. PMID: 29600948
  88. Plumb J, Mallin M, Bolte RG. The role of ultrasound in the emergency department evaluation of the acutely painful pediatric hip. Pediatr Emerg Care 2015; 31(1): 54-8. doi: 10.1097/PEC.0000000000000332 PMID: 25560622
  89. Zoabi M, Kvatinsky N, Shavit I. Evaluation of a point-of-care ultrasonography decision-support algorithm for the diagnosis of transient synovitis in the pediatric emergency department. JAMA Netw Open 2021; 4(7): e2116915. doi: 10.1001/jamanetworkopen.2021.16915 PMID: 34255053
  90. Shahid M, Holton C, O’Riordan S, Kraft JK. Sonography of musculoskeletal infection in children. Ultrasound 2020; 28(2): 103-17. doi: 10.1177/1742271X20901736 PMID: 32528546
  91. Hosokawa T, Tanami Y, Sato Y, Deguchi K, Takei H, Oguma E. Role of ultrasound in the treatment of pediatric infectious diseases: Case series and narrative review. World J Pediatr 2023; 19(1): 20-34. doi: 10.1007/s12519-022-00606-5 PMID: 36129633
  92. Vidovic M, Perica M, Lamot L, Bukovac L, Harjacek M. Musculoskeletal ultrasound as complementary tool in assessing and monitoring children with reactive arthirits REA - Single Center Experience AB0993 74(Suppl 2):1230.3-1231. Annials of the Rheumatic Diseases 2015; 74 (Suppl. 2): 1230-1. doi: 10.1136/annrheumdis-2015-eular.6309
  93. Borocco C, Anselmi F, Rossi-Semerano L. Contribution of ultrasound in current practice for managing juvenile idiopathic arthritis. J Clin Med 2022; 12(1): 91. doi: 10.3390/jcm12010091 PMID: 36614888
  94. Zwir LF, Terreri MT. do Amaral e Castro A, Rodrigues WDR, Fernandes ARC. Is power Doppler ultrasound useful to evaluate temporo-mandibular joint inflammatory activity in juvenile idiopathic arthritis? Clin Rheumatol 2020; 39(4): 1237-40. doi: 10.1007/s10067-019-04731-x PMID: 31396836
  95. Demirkaya E, Özçakar L, Türker T, et al. Musculoskeletal sonography in juvenile systemic lupus erythematosus. Arthritis Rheum 2009; 61(1): 58-60. doi: 10.1002/art.24090 PMID: 19116978
  96. Shenoy S, Aggarwal A. Sonologic enthesitis in children with enthesitis-related arthritis. Clin Exp Rheumatol 2016; 34(1): 143-7. PMID: 26812448
  97. Habers GEA, Van Brussel M, Bhansing KJ, et al. Quantitative muscle ultrasonography in the follow-up of juvenile dermatomyositis. Muscle Nerve 2015; 52(4): 540-6. doi: 10.1002/mus.24564 PMID: 25557638
  98. Sudoł-Szopińska I, Jacques T, Gietka P, Cotten A. Imaging in dermatomyositis in adults and children. J Ultrason 2020; 20(80): e36-42. doi: 10.15557/JoU.2020.0007 PMID: 32320164
  99. Song Y, Lee S, Yoo DH, Jang KS, Bae J. Strain sonoelastography of inflammatory myopathies: Comparison with clinical examination, magnetic resonance imaging and pathologic findings. Br J Radiol 2016; 89(1065): 20160283. doi: 10.1259/bjr.20160283 PMID: 27401595
  100. Sridharan A, Eisenbrey JR, Forsberg F, Lorenz N, Steffgen L, Ntoulia A. Ultrasound contrast agents: Microbubbles made simple for the pediatric radiologist. Pediatr Radiol 2021; 51(12): 2117-27. doi: 10.1007/s00247-021-05080-1 PMID: 34117892

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2024 Bentham Science Publishers