Atypical keratoacanthoma: a case report

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Abstract

In this article we summarized etiopathogenesis and clinical data, presented classification and described diagnosis challenges. One of the most common epithelial tumors, keratoacanthoma (KA) is characterized by rapid growth, histopathological features of squamous cell skin cancer and spontaneous regression tendency. Differential diagnosis of typical and atypical KA can be challenging since an early stage atypical KA may present similar to typical KA. Immunomorphological and immunohistochemical methods are particularly relevant for detecting atypical KA, making it possible to reliably differentiate it from squamous cell skin cancer. Years of experience in the management of KA patients, as well as foreign researchers’ data, suggest that the treatment approach should be based on the differentiation of clinical features of a typical KA from an atypical one.
This report describes a clinical case of a giant keratoacanthoma.

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About the authors

Elena S. Snarskaya

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: snarskaya-dok@mail.ru
ORCID iD: 0000-0002-7968-7663
Scopus Author ID: 8714450500

MD, PhD, DSc., professor of the Department of skin and venereal diseases of I.M. Sechenov First Moscow State Medical University (Sechenov University)

Russian Federation, Moscow

L. M. Shnakhova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: Lika-slm@mail.ru
ORCID iD: 0000-0003-3000-0987

Assistant of the department of skin and venereal diseases named after V.A. Rakhmanova

Russian Federation, Moscow

D. A. Gomich

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: gomich28@icloud.com
ORCID iD: 0000-0002-4624-3046

Ordinator of the department of skin and venereal diseases named after V.A. Rakhmanova

Russian Federation, Moscow

K. D. Vasileva

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: kseniya07101988@mail.ru
ORCID iD: 0000-0001-8693-9622

Ordinator of the department of skin and venereal diseases named after V.A. Rakhmanova

Russian Federation, Moscow

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