Combination of isotretinoin and Contractubex Anti-Red in acne therapy

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BACKGROUND: Acne vulgaris (acne vulgaris) is an urgent interdisciplinary problem. Analyzing modern scientific data on the development of acne vulgaris, it is necessary to focus on the role of inflammation that accompanies dermatosis at all its stages of development, sometimes preceding the formation of clinical symptoms. Prolonged chronic recurrent course, difficulties in choosing the correct therapy tactics, sometimes unreasonable medical interventions, exacerbation, improper skin care lead to the formation of a number of complications.

AIMS: To optimize and improve the effectiveness of therapy in patients with moderate and severe degrees acne using isotretinoin and the combined innovative gel Contractubex Anti-Red.

MATERIALS AND METHODS: The study included 60 patients aged 18 to 45 years with moderate to severe acne. Isotretinoin was prescribed in standard dosages. To study the effect of Contraktubex Anti-Red on the dynamics of post-acne, patients with atrophic post-acne scars were divided into 3 subgroups, depending on the regimen of drug use.

RESULTS: Almost complete relief of the inflammatory process, regression of elements was noted 12 months after the use of complex therapy, the value of the dermanologic index of acne (DIA) index was more than 70% noted in 62% of patients, significant improvement in 38%. The severity of post-acne scars on the SCAR-S scale changed significantly during treatment and in 53.3% this indicator was 1. The Cadi index decreased by 70% compared to the baseline.

CONCLUSION: Good cosmetic effect, safety, absence of side effects, comfort and ease of use make it possible to recommend Contractubex Anti-Red together with basic acne therapy.


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Olga A. Katkhanova

Rostov State Medical University

Author for correspondence.
ORCID iD: 0000-0002-4537-401X
SPIN-code: 8935-3537

MD, Dr. Sci. (Med.), Professor

Russian Federation, 119 Suvorova st., Rostovskaya obl, 344022, Rostov-on-Don

Svetlana A. Grigoryants

Kuban State Medical University

ORCID iD: 0000-0002-7625-0503

Graduate Student

Russian Federation, Krasnodar

Irina I. Glazko

Burnasyan Federal Medical Biophysical Center

ORCID iD: 0000-0001-8512-3736

MD, Cand. Sci. (Med.), Associate Professor

Russian Federation, Moscow


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Supplementary files

Supplementary Files
1. Fig. 1. Varieties of atrophic scars according to C.I. Jacob et al. [9].

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2. Fig. 2. Classification of acne European Evidence-based (S3) Guidelines for the Treatment of Acne (2016, EADV); B. Dreno et al. (2013, EADV).

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3. Fig. 3. The system for assessing the severity of post-acne scars (Acne Scar Severity Score, SCAR-S).

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4. Fig. 4. DIA dynamics in the course of complex therapy of acne with isotretinoin and Kontraktubex Anti-Red gel.

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5. Fig. 5. The severity of acne scars SCAR-S during treatment.

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6. Fig. 6. Patient A., clinical manifestations of acne at the beginning of therapy, after 6 and 12 months.

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7. Fig. 7. Patient S., clinical manifestations of acne at the beginning of therapy, after 6 and 12 months.

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8. Fig. 8. Patient S., clinical manifestations of acne at the beginning of therapy, after 6 and 12 months.

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 80653 от 15.03.2021 г

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