Combination of isotretinoin and Contractubex Anti-Red in acne therapy

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

BACKGROUND: Acne vulgaris (acne vulgaris) is an urgent interdisciplinary problem. Analyzing modern scientific data on the development of acne vulgaris, it is necessary to focus on the role of inflammation that accompanies dermatosis at all its stages of development, sometimes preceding the formation of clinical symptoms. Prolonged chronic recurrent course, difficulties in choosing the correct therapy tactics, sometimes unreasonable medical interventions, exacerbation, improper skin care lead to the formation of a number of complications.

AIMS: To optimize and improve the effectiveness of therapy in patients with moderate and severe degrees acne using isotretinoin and the combined innovative gel Contractubex Anti-Red.

MATERIALS AND METHODS: The study included 60 patients aged 18 to 45 years with moderate to severe acne. Isotretinoin was prescribed in standard dosages. To study the effect of Contraktubex Anti-Red on the dynamics of post-acne, patients with atrophic post-acne scars were divided into 3 subgroups, depending on the regimen of drug use.

RESULTS: Almost complete relief of the inflammatory process, regression of elements was noted 12 months after the use of complex therapy, the value of the dermanologic index of acne (DIA) index was more than 70% noted in 62% of patients, significant improvement in 38%. The severity of post-acne scars on the SCAR-S scale changed significantly during treatment and in 53.3% this indicator was 1. The Cadi index decreased by 70% compared to the baseline.

CONCLUSION: Good cosmetic effect, safety, absence of side effects, comfort and ease of use make it possible to recommend Contractubex Anti-Red together with basic acne therapy.

Keywords

Full Text

Restricted Access

About the authors

Olga A. Katkhanova

Rostov State Medical University

Author for correspondence.
Email: okathanova@mail.ru
ORCID iD: 0000-0002-4537-401X
SPIN-code: 8935-3537

MD, Dr. Sci. (Med.), Professor

Russian Federation, 119 Suvorova st., Rostovskaya obl, 344022, Rostov-on-Don

Svetlana A. Grigoryants

Kuban State Medical University

Email: svetulya2597@mail.ru
ORCID iD: 0000-0002-7625-0503

Graduate Student

Russian Federation, Krasnodar

Irina I. Glazko

Burnasyan Federal Medical Biophysical Center

Email: irinap17@yandex.ru
ORCID iD: 0000-0001-8512-3736

MD, Cand. Sci. (Med.), Associate Professor

Russian Federation, Moscow

References

  1. Dreno B, Layton A, Zouboulis C, et al. Adult female acne:a new paradigm. J Eur Acad Dermatol Venereol. 2013;27(9):1063–1070. doi: 10.1111/jdv.12061
  2. Thiboutot DM, Dreno B, Abanmi A, et al. Practical management of acne for clinicians: an international consensus from Global Alliance to improve outcomes in acne. J Am Acad Dermatol. 2018;78(2 Suppl 1):S1–S23. doi: 10.1016/j.jaad.2017.09.078
  3. Demina OM, Potekaev NN, Kartelishev AV. Clinical and pathogenetic features and methods of therapy of late forms of acne in women. Clinical Dermatology and Venereology. 2015;14(6):133–137. (In Russ). doi: 10.17116/klinderma2015146133-137
  4. Lvov AN, Kornyat MS, Igoshina AV, Nazarenko AR. Perspectives in acne therapy: an analytical review. Klinicheskaya Dermatologiya i Venerologiya. 2019;18(2):115–128. doi: 10.17116/klinderma201918021115
  5. Nast A, Dréno B, Bettoli V, et al. European evidence-based (S3) guideline for the treatment of acne-update 2016: short version. J Eur Acad Dermatol Venereol. 2016;30(8):1261–1268. doi: 10.1111/jdv.13776
  6. Carlavan I, Bertino B, Rivier M, et al. Atrophic scar formation in patients with acne involves long-acting immune responses with plasma cells and alteration of sebaceous glands. Br J Dermatol. 2018;179(4):906–917. doi: 10.1111/bjd.16680
  7. Hayashi N, Miyachi Y, Kawashima M. Prevalence of scars and “Mini-Scars”, and their impact on quality of life in Japanese patients with acne. J Dermatol. 2015;42(7):690–696. doi: 10.1111/1346-8138.12885
  8. Ufimtseva MA, Simonova NV, Bochkarev YM, et al. Methods of clinical assessment and treatment of post-acne atrophic scars. Modern Problems of Science and Education. 2020;(2):166. (In Russ). doi: 10.17513/spno.29704
  9. Jacob CI, Dover JS, Kaminer MS. Acne scarring: a classification system and review of treatment options. J Am Acad Dermatol. 2001;45(1):109–117. doi: 10.1067/mjd.2001.113451
  10. Clark AK, Saric S, Sivamani RK. Acne scars: how do we grade them? Am J Clin Dermatol. 2018;19(2):139–144. doi: 10.1007/s40257-017-0321-x
  11. Kang S, Lozada VT, Bettoli V, et al. New atrophic acne scar classification: reliability of assessments based on size, shape, and number. J Drugs Dermatol. 2016;15(6):693–702.
  12. Sanakoeva EG. Multifactorial analysis of the features of the course, diagnosis and treatment of acne of moderate and severe severity as a basis for improving the quality of medical care [dissertation abstract]. Moscow; 2019. 27 p. (In Russ).
  13. Tolstaya AI, Zilberberg NV. The effectiveness of ablative fractional photothermolysis in the complex therapy of inflammatory acne and atrophic post-acne scars. Modern Problems of Dermatovenerology, Immunology and Medical Cosmetology. 2013;(4):41–49. (In Russ).
  14. Goodman GJ, Baron JA. Postacne scarring: a qualitative global scarring grading system. Dermatol Surg. 2006;32(12):1458–1466. doi: 10.1111/j.1524-4725.2006.32354.x
  15. Katkhanova OA, Katkhanov AM. Acne from the position of a dermatologist and cosmetologist. Bulletin of Dermatology and Venereology. 2014;90(4):75–82. (In Russ).
  16. Katkhanova ОА, Katkhanov АM. The experience in the use of topical retinoids and azelaic acid in therapy of acne. Klinicheskaya Dermatologia i Venerologia. 2015;(6):120–125. doi: 10.17116/klinderma2015146120-125
  17. Kochergin NA, Samgin MA, Monakhov SA, Ignatiev D. Dermatological index of acne. Aesthetic Medicine. 2004;3(1):62–65.
  18. Tan JK, Tang J, Fung K, et al. Development and validation of a Scale for Acne Scar Severity (SCAR-S) of the face and trunk. J Cutan Med Surg. 2010;14(4):156–160. doi: 10.2310/7750.2010.09037

Supplementary files

Supplementary Files
Action
1. Fig. 1. Varieties of atrophic scars according to C.I. Jacob et al. [9].

Download (345KB)
Indexing metadata
2. Fig. 2. Classification of acne European Evidence-based (S3) Guidelines for the Treatment of Acne (2016, EADV); B. Dreno et al. (2013, EADV).

Download (245KB)
Indexing metadata
3. Fig. 3. The system for assessing the severity of post-acne scars (Acne Scar Severity Score, SCAR-S).

Download (227KB)
Indexing metadata
4. Fig. 4. DIA dynamics in the course of complex therapy of acne with isotretinoin and Kontraktubex Anti-Red gel.

Download (145KB)
Indexing metadata
5. Fig. 5. The severity of acne scars SCAR-S during treatment.

Download (115KB)
Indexing metadata
6. Fig. 6. Patient A., clinical manifestations of acne at the beginning of therapy, after 6 and 12 months.

Download (238KB)
Indexing metadata
7. Fig. 7. Patient S., clinical manifestations of acne at the beginning of therapy, after 6 and 12 months.

Download (143KB)
Indexing metadata
8. Fig. 8. Patient S., clinical manifestations of acne at the beginning of therapy, after 6 and 12 months.

Download (151KB)
Indexing metadata

Copyright (c) 2021 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 015912 от 28.03.1997 г. 
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 80653 от 15.03.2021 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies