Determination of the Microelement Composition of Biopsy Material of Red Bone Marrow in Patients with Hemoblastoses by the SR–XRF Method

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Abstract

Personalized medicine is a modern concept aimed at individualization of patient therapy. The relevance of the search and identification of new highly sensitive and specific prognostic markers in patients with hemoblastoses is due to the leading positions in the incidence and mortality rate among young working-age population, which gives the problem special socio-economic significance. The study is aimed at studying the content of trace elements in biopsy material (red bone marrow) of patients with hemoblastoses at the onset of the disease and after chemoradiation therapy. Using the method of X-ray fluorescence analysis and synchrotron radiation, it is possible to simultaneously determine more than 25 chemical elements in a low-mass sample with non-destructive sample preparation. Difference in the concentrations of 10 elements (S, K, Ca, Cu, Zn, Fe, Se, Br, Rb, Cd) in patients with two pathologies, lymphoma and leukemia, is considered.

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About the authors

V. A. Trunova

Nikolaev Institute of Inorganic Chemistry of the Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University

Author for correspondence.
Email: valna-t@mail.ru
Russian Federation, Novosibirsk; Novosibirsk

T. I. Pospelova

Novosibirsk State Medical University

Email: valna-t@mail.ru
Russian Federation, Novosibirsk

M. S. Voytko

Novosibirsk State Medical University

Email: valna-t@mail.ru
Russian Federation, Novosibirsk

E. S. Krupovich

Nikolaev Institute of Inorganic Chemistry of the Siberian Branch of the Russian Academy of Sciences; Institute of Catalysis of the Siberian Branch of the Russian Academy of Sciences

Email: valna-t@mail.ru
Russian Federation, Novosibirsk; Koltsovo

G. S. Soldatova

Novosibirsk State Medical University; Novosibirsk State University

Email: valna-t@mail.ru
Russian Federation, Novosibirsk; Novosibirsk

R. O. Kuzmin

Novosibirsk State Medical University

Email: valna-t@mail.ru
Russian Federation, Novosibirsk

K. S. Tsigulyov

Novosibirsk State Medical University

Email: valna-t@mail.ru
Russian Federation, Novosibirsk

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Supplementary files

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2. Fig. 1. Incidence and mortality rates of patients with haemoblastosis from 2018 to 2023.

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3. Fig. 2. Study design. NHL - non-Hodgkin's lymphoma, PCT - polychemotherapy.

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4. Fig. 3. Results of elemental analysis of red bone marrow of leukaemia patients: 1 - before polychemotherapy; 2 - after the first course; 3 - after the second course.

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5. Fig. 4. Results of elemental analysis of red bone marrow of patients with lymphoma: 1 - before polychemotherapy; 2 - after the first course; 3 - after the second course.

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