The initial of Autonomic Tone Determines the Development of Irreversible Myocardial Ischemia in Rats

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

The method of HRV analysis in rats was used to evaluate the relationship between the initial level of total HRV and regulatory changes in the work of the heart before and on days 1, 3, and 28 after the modeling of irreversible ischemia (II). According to the level of total HRV, rats were divided into two groups: with initially “low” and “high” levels of HRV, the LV (SDRR = 5.0 ms) and HV (SDRR = 8.2 ms) groups. LV and HV rats reacted differently to the cold test before and after II. Three days after II, LV rats had a better preservation of the autonomic regulation of the heart, and 28 days later, a smaller size of myocardial damage and mortality. In HV rats, the number of mast cells in the ischemic focus was higher, and in the zone unaffected by ischemia, the proportion of degranulated cells was higher than in LV rats.

Авторлар туралы

M. Morozova

Faculty of Fundamental Medicine, Lomonosov Moscow University

Email: mormasha@gmail.com
119991 Russia, Moscow

A. Kurenkova

Institute of Regenerative Medicine, Sechenov Moscow Medical University

Email: mormasha@gmail.com
119991 Russia, Moscow

Ju. Volkova

University of Zurich, Institute of Physiology

Email: mormasha@gmail.com
Switzerland, 8057, Zürich, Winterthurerstrasse 190

A. Berdalin

Federal State Budgetary Institution “Federal center of brain research and neurotechnologies” of the Federal Medical Biological Agency

Email: mormasha@gmail.com
117513 Russia, Moscow

E. Banzeluk

Faculty of Fundamental Medicine, Lomonosov Moscow University

Email: mormasha@gmail.com
119991 Russia, Moscow

B. Umarova

Faculty of Biology, Lomonosov Moscow University

Email: mormasha@gmail.com
119234 Russia, Moscow

E. Lukoshkova

Federal State Budgetary Institution National medical research center of cardiology Ministry of Health of the Russian Federation

Email: mormasha@gmail.com
121552 Russia, Moscow

S. Gavrilova

Faculty of Fundamental Medicine, Lomonosov Moscow University

Email: mormasha@gmail.com
119991 Russia, Moscow

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© М.П. Морозова, А.Д. Куренкова, Ю.Л. Волкова, А.Б. Бердалин, Е.Н. Банзелюк, Б.А. Умарова, Е.В. Лукошкова, С.А. Гаврилова, 2023