Severity of COVID-19 in Pregnant Women: A Review on the Potential Role of Regulatory T Cells


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As a physiological condition, pregnancy may cause temporary alterations in the hematological, cardiopulmonary, and immune responses, affecting the maternal susceptibility to viral infections. Pregnant women are vulnerable to infection with the influenza A virus, hepatitis E virus, MERS CoV, and SARS CoV. The agent of Coronavirus disease (COVID-19) is the SARS coronavirus (SARS CoV-2), which affects the cells upon binding to the angiotensin-converting enzyme-2 (ACE2). However, ACE2 expression is elevated in the placental tissue. However, surprisingly, COVID-19 infection in pregnant women tends to have a lower severity and mortality. Therefore, it is interesting to find the immunological mechanisms related to the severity of COVID-19 in pregnancy. Regulatory T cells (Tregs) are a subset of CD4+T cells that may play a central role in maintaining maternal tolerance by regulating immune responses. Pregnancy-induced Tregs are developed to control immune responses against paternal antigens expressed by the semi-allograft fetus. The role of uncontrolled immune responses in COVID-19 pathogenesis has already been identified. This review provides insight into whether pregnancy- induced regulatory T-cell functions could influence the severity of COVID-19 infection during pregnancy.

Sobre autores

Nafiseh Saghafi

Department of Obstetrics and Gynecology, Faculty of Medicine,, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Mahmoud Mahmoudi

Department of Immunology and Allergy, School of Medicine,, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Amir Momtazi-Borojeni

Department of Advanced Technologies in Medicine, School of Medicine, Neyshabur University of Medical Sciences

Email: info@benthamscience.net

Sara Mirzaeian

Department of Obstetrics and Gynecology, Faculty of Medicine,, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Fataneh Tavasolian

, Toronto Western Hospital

Email: info@benthamscience.net

Thozhukat Sathyapalan

Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull

Email: info@benthamscience.net

Elham Abdollahi

Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences

Autor responsável pela correspondência
Email: info@benthamscience.net

Amirhossein Sahebkar

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences

Autor responsável pela correspondência
Email: info@benthamscience.net

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