编号 2 (2021)

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Articles

Formation, development and activities of the Department of Clinical Toxicology of the Russian Medical Academy of Continuous Professional Education

Gol′dfarb Y., Kabanova S., Lezhenina N., Potskhveriya M., Ostapenko Y., Sleptsov V.

摘要

The creation of an emergency clinical toxicology service in our country led to the need to train clinical toxicologists and to create a specialized Department for this purpose, which was opened in 1985 at the Central Institute of Advanced Medical Training. The staff of the Department carried out a lot of methodological, educational and scientific work, which allowed to achieve a high level of teaching. Successful activity of the Department was promoted by: work on the clinical basis of a multidisciplinary research medical institution – N.V. Sklifosovsky Research Institute for Emergency Medicine; admission to the Institute a large number of patients with various intoxications ensuring thematic completeness of teaching; the unity of command in the leadership of the Toxicological Department of the N.V. Sklifosovsky Research Institute for Emergency Medicine and the Department of Clinical Toxicology of the Russian Medical Academy of Continuous Professional Education in the person of E.A. Luzhnikov, who used his experience in scientific, practical and teaching activities of the Department; due to the existence of the scientific school of academician E.A. Luzhnikov – the development of new technologies for screening, treatment and rehabilitation of acute poisonings; the use of modern teaching methods, including field cycles and distance learning technologies; close interaction with scientific societies, contributing to a significant expansion of the possibilities of new teaching methods.

Toxicological Review. 2021;(2):2-13
pages 2-13 views

Optimization of statistical processing of clinical and laboratory data in acute poisoning

El’kov A., Gol’dfarb Y., Potskhveriya M., Badalyan A.

摘要

The article describes a specialized software application developed by the authors that summarizes the long-term experience of analyzing clinical and laboratory data in clinical toxicology using Microsoft’s Visual Basic for Applications object-oriented programming tools in Excel. The main purpose of the application is a significant (5-10 times) acceleration of the implementation of the complex of the most commonly used statistical algorithms. The application calculates descriptive sample characteristics, identifies deviations of sample distributions from the normal law by several generally accepted criteria, performs statistical comparison of data matrices by several criteria, and automatically generates a number of tables ready for placement in scientific texts for various purposes in Microsoft Word format. The presentation of the output data makes it easy to verify the results of calculations by comparing them with the output forms of the Statistica application software package. The acceleration of obtaining the final result is achieved: 1 – due to the absence of the need to move data from Excel to the package of applied statistical programs; 2 – as a result of automating the determination of task parameters by means of special color markup; 3 – by combining a limited number of the most commonly used statistical methods into one immutable complex; 4 – as a result of the software implementation of statistical comparison of all possible combinations of data matrices involved in the study for a set of indicators as a single operation that does not require user intervention; 5 – due to the application’s use of syntactic transformations of output data and automatic table formation by filling in ready-made templates with calculation results.

Toxicological Review. 2021;(2):14-22
pages 14-22 views

Features of disturbance of oxidative stress markers and venous blood cells apoptosis in the early stage of acute poisoning by corrosive substances

Il′yashenko K., Evseev A., Borovkova N., Klychnikova E., Goroncharovskaya I., Simonova A., Tazina E., El′kov A., Potskhveriya M., Shabanov A., Andreev Y.

摘要

The character of disturbance of oxidative stress markers and venous blood cells apoptosis in patients with corrosive substances poisoning in early stage was studied. In the first 5 days for the estimation of the oxidative stress severity the lipid peroxidation (LPO) products, antioxidant system (AOS) state and value of the platinum electrode open circuit potential (OCP) were determined. Apoptosis was studied by measuring of apoptotic lymphocytes and dead leukocytes concentration. It was found that in patients younger than 60 years in response to the intake of corrosive substance, peroxidation processes are the first to activate, as evidenced by the oxidative stress development and its increase in dynamics. The apoptosis processes are activated only as oxidative stress severity increase which indicates the development of an adequate reaction to the acute chemical trauma in persons of working age. Contrariwise, in patients older than 60 years apoptosis of venous blood lymphocytes is first activated followed by peroxidation processes activation. Moreover, the low activity of LPO/AOS system is noted in the whole. This fact indicates the absence of an adequate reaction to the intake of corrosive substance in this category of patients.

Toxicological Review. 2021;(2):23-32
pages 23-32 views

Epidemiology of acute poisonings with gammahydroxybutyric acid in Saint Petersburg (according to data of a multidisciplinary hospital)

Sinenchenko A., Lodyagin A., Batotsyrenov B., Balabanova O.

摘要

It was found that for the period from X.2017 to III.2020 among patients admitted to a multidisciplinary hospital with acute poisoning with narcotic drugs (NV) and psychoactive substances (PAS), persons in whose biological environment GHB was detected ranged from 20,1 to 40,1%. The prevalence of acute poisoning of the studied class in male patients (86%) of working age (the average age was 34,2 ± 2,9 year) was proved. The patients used 1,4-butanediol (1,4-BD) as a toxicant (GHB) in 95% of cases. The dynamics of the incidence of acute GHB poisoning over a three-year period was uneven, with peaks of maximum values in August (Me = 168), March (Me = 90), and September (Me = 103) and low rates - in June (Me = 71) and total upward trend - y = 6,6573x = 343,23, R2 = 0,053. The severity of acute GHB poisoning at the time of admission on the PSS scale was 2,2 ± 0,57 points, PSSSP – 22,7 ± 2,17 points. Acute GHB poisoning was characterized by signs of toxic-hypoxic encephalopathy, clinically manifested in the form of depression of consciousness to the level of deep stunning - coma. The duration of inpatient treatment of patients was (1,76 ± 3,7, min = 1, max = 35) days, the period of stay in the intensive care unit (ICU) was 4,2 ± 0,4 hours. The increase in hospitalization (more than a day) was due to somatic complications of acute poisoning (nasocomial pneumonia, systemic rhabdomyolysis, acute renal failure) - in 14% of cases, severe withdrawal syndrome with delirious confusion - in 3,5% of cases. The post-intoxication period was characterized by moderate withdrawal symptoms – 13,7 ± 2,1 points, according to the CIWA-Ar scale. The delirious syndrome was characterized by a protracted course (9,5 ± 1,2 days), an atypical clinical picture, and metabolic disorders. The mortality rate due to acute GHB poisoning increased from 0,09 to 0,22%, in 2019 the cause of death was pronounced degenerative changes in internal organs and varying degrees of severity of microcirculation disorders.

Toxicological Review. 2021;(2):33-40
pages 33-40 views

Health of workers with occupational diseases who contacted with chemical harmful production factors

Gurev A., Tukov A., Kretov A.

摘要

For persons with occupational diseases who worked at enterprises and organizations served by medical institutions of the FMBA of the Russian Federation, it is relevant to assess their health, taking into account the impact of harmful chemical production factors that have become the causes of their occupational diseases. About 2/3 of cases of occupational diseases caused by chemical hazards are organophosphorus compounds (pesticides), beryllium and its compounds. Of the diseases of non-professional genesis, this group of persons has the highest prevalence of diseases of the circulatory system, musculoskeletal system, digestive and respiratory organs. Of the diseases of the circulatory system, the most commonly diagnosed diseases are those characterized by high blood pressure and coronary heart disease. The structure of diseases of the digestive system is dominated by diseases of the esophagus, stomach and duodenum, diseases of the gall bladder, biliary tract and pancreas. Dorsopathies are the most common within the musculoskeletal disorders; chronic diseases of the upper and lower respiratory tract – within the respiratory diseases.

Toxicological Review. 2021;(2):41-45
pages 41-45 views

New information on toxicity and hazard of chemical and biological substances

Study of the state of laboratory animals after subchronic oral exposure to solid rocket fuels component

Maslennikov A., Bocharova L., Khodykina N., Pocheptsov A., Grishina M., Antonov V.

摘要

The toxic effect of poly[3,3-bis(azidomethyl)oxetane] of high molecular weight in subchronic oral intake of white mongrel rats was investigated. It has been found that in a one month experiment the compound at doses of 90,0 mg/kg, 30,0 mg/kg, and 10,0 mg/kg caused a change in the complex of physiological, behavioral, hematological, biochemical, immunological, and pathomorphological parameters in animals. At the same time, the cumulative properties of the toxicant were not registered.
The deviations revealed were dose-dependent. Thus, during the entire period of intragastric administration of the substance, 15 significant changes were noted in the males of the first group, two of which went beyond the 2 sigma deviations in relations to the control values. The same ratio for the second experimental group was 10/1. The oral intake of the substance under investigation at minimum dose was accompanied by 5 violations in the homeostasis of the experimental animals, which did not go beyond the 2 sigma values in relations to the control values.
Taking into account the insignificant number of changes detected and based on the current diagnostic criteria, the dose of 10,0 mg/kg has been accepted as a threshold of subacute general toxic effect for poly[3,3-bis(azidomethyl) oxetane] of high molecular weight.
The obtained data was used when developing the maximum permissible concentration of the estimated component of solid rocket fuels in the water of water bodies.

Toxicological Review. 2021;(2):46-50
pages 46-50 views

Nephro- and hepatotoxicity of uranyl acetate in 18-week chronic administration to rats

Sivak K., Stosman K., Savateeva-Lubimova T.

摘要

The paper presents the results of an experimental study of the hepato- and nephrotoxicity of uranyl acetate dihydrate (UA) in 18-week chronic intragastric administration in doses of 0,5 and 5,0 mg/kg of the element. The study was performed on 45 male mongrel rats. A dose-dependent change in laboratory biochemical parameters of blood and urine of rats treated with the toxicant was revealed. Nephrotoxicity is characterized by multiple disorders of the functions of the proximal and distal tubules and glomeruli of nephrons. A pathoanatomic study revealed gross violations in the liver and kidney cytoarchitectonics of rats treated with UA in a dose of 5,0 mg/ kg. In liver, there were uneven regenerative phenomena in the form of nucleomegaly, the development of granular protein dystrophy of various degrees (up to necrosis), periportal lymphohistiocytic infiltration and periportal fibrosis. In kidneys, there were the development of chronic diffuse tubulointerstitial nephrofibrosis with significant lymphoplasmocytic infiltration, atrophy of the epithelium of the proximal and distal tubules, cystic transformation of the renal parenchyma.

Toxicological Review. 2021;(2):51-58
pages 51-58 views

Acute toxicity of nanoscale form of 20-hydroxyecdysone in intragastric administration

Erimbetov K., Fedorova A., Goncharova A., Obvintseva O.

摘要

The nanoscale 20-hydroxyecdysone was first proposed and obtained in the form of a clathrate complex with arabinogalactan with an average particle size of 35,3 nm. The study of its acute toxicity has revealed that the product belongs to class VI of relatively harmless drugs according to Hodge and to class 5th in accordance with GOST 32644-2014.

Toxicological Review. 2021;(2):59-63
pages 59-63 views

Anniversary

Savateev Nikolai Vasil’evich (to the 100th birthday )

Editorial a.

摘要

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Toxicological Review. 2021;(2):63-64
pages 63-64 views