About the threshold concentration of nickel oxide nanoparticles in long-term inhalation exposure of rats

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Introduction. Nickel oxide nanoparticles are of interest for toxicological science, not only as engineered nanoparticles, producing for industrial and scientific needs, but also as spontaneous pollutants of the atmosphere and the working area in industrial processes related to metallurgy and welding.

Materials and methods. Rats were exposed to nickel-oxide aerosol at a concentration of 2.4 ± 0.4 µg/m3 in a “nose only” inhalation setup for 4 hours at a time, 5 times a week, during an overall period of 2 weeks to 6 months. 

Results. Of the several dozen examined parameters, only a few statistically significant manifestations associated with the reaction of the deep airways to inhaled nanoparticles were noted. However, in the biochemical and morphometric parameters of the lungs, even at the longest periods of exposure, the intergroup differences were insignificant. At the same time, even from the first weeks of the exposure period, genotoxic and allergic indices shifts are detected.

Conclusion. For most of the evaluated effects, this level of exposure to nickel oxide nanoparticles may be considered as close to LOAEL, or even to NOAEL. However, according to some indicators, there are effects that suggest a non-threshold nature.

Sobre autores

Boris Katsnelson

FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor

Autor responsável pela correspondência
Email: bkaznelson@ymrc.ru
ORCID ID: 0000-0001-8750-9624

MD, professor, scientific consultant FBRI YMRC PHPIW of Rospotrebnadzor, 620014, Yekaterinburg, Russia.

e-mail: bkaznelson@ymrc.ru

Rússia

Ivan Chernyshov

FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor

Email: chernishov@ymrc.ru
ORCID ID: 0000-0002-2018-5386

Младший научный сотрудник отдела токсикологии и биопрофилактики ФБУН ЕМНЦ ПОЗРПП
Роспотребнадзора, г. Екатеринбург, Российская Федерация.

e-mail: chernishov@ymrc.ru

Rússia

Svetlana Solovyeva

FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor

Email: solovyevasn@ymrc.ru
ORCID ID: 0000-0001-8580-403X

Заведующая клиникой экспериментальных животных ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора, г. Екатеринбург, Российская Федерация.

e-mail: solovyevasn@ymrc.ru

Rússia

Ilzira Minigalieva

FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor

Email: ilzira-minigalieva@yandex.ru
ORCID ID: 0000-0002-0097-7845

Доктор биологических наук, заведующий отделом токсикологии и биопрофилкатики, заведующий лабораторией промышленной токсикологии ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора, г. Екатеринбург, Российская Федерация.

e-mail: ilzira-minigalieva@yandex.ru

Rússia

Vladimir Gurvich

FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor

Email: gurvich@ymrc.ru
ORCID ID: 0000-0002-6475-7753

Доктор медицинских наук, профессор, научный руководитель ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора, г. Екатеринбург, Российская Федерация.

e-mail: gurvich@ymrc.ru

Rússia

Irene Valamina

The Ural State Medical University

Email: ivalamina@mail.ru
ORCID ID: 0000-0001-7387-5287

Кандидат медицинских наук, старший научный сотрудник, заведующая лабораторией ЦНИЛ ГБОУ ВПО УГМУ, г. Екатеринбург, Российская Федерация.

e-mail: ivalamina@mail.ru

Rússia

Oleg Makeyev

The Ural State Medical University

Email: oomt305@maii.ru
ORCID ID: 0000-0001-6819-3185

Доктор медицинских наук, профессор, заведующий лабораторией технологий клеточной и генной терапии Института медицинских клеточных технологий, ГБОУ ВПО УГМУ, г. Екатеринбург, Российская Федерация.

e-mail: oomt305@maii.ru

Rússia

Renata Sahautdinova

FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor

Email: sahautdinova@ymrc.ru
ORCID ID: 0000-0002-2726-9259

Кандидат медицинских наук, заведующий диагностическим лабораторным отделением НПО «Диагностических лабораторных технологий» ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора, г. Екатеринбург, Российская Федерация.

e-mail: sahautdinova@ymrc.ru

Rússia

Larisa Privalova

FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor

Email: privalovali@yahoo.com
ORCID ID: 0000-0002-1442-6737

Доктор медицинских наук, профессор, заведующий лабораторией научных основ биопрофилактики ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора, г. Екатеринбург, Российская Федерация.

e-mail: privalovali@yahoo.com

Rússia

Anastasia Tsaregorodtseva

The Ural State Medical University

Email: aisha12_95@mail.ru
ORCID ID: 0000-0001-9444-8399

Младший научный сотрудник лаборатории ЦНИЛ ГБОУ ВПО УГМУ, г. Екатеринбург, Российская Федерация.

e-mail: aisha12_95@mail.ru

Rússia

Artem Korotkov

The Ural State Medical University

Email: oomt305@maii.ru
ORCID ID: 0000-0001-5114-6104

Кандидат медицинских наук, ведущий научный сотрудник лаборатории технологий клеточной и генной терапии Института медицинских клеточных технологий, ГБОУ ВПО УГМУ, г. Екатеринбург, Российская Федерация.

e-mail: oomt305@maii.ru

Rússia

Evgeny Shuman

The Ural State Medical University

Email: oomt305@maii.ru
ORCID ID: 0000-0003-1981-4330

Мадший научный сотрудник лаборатории технологий клеточной и генной терапии Института медицинских клеточных технологий, ГБОУ ВПО УГМУ, г. Екатеринбург, Российская Федерация.

e-mail: oomt305@maii.ru

Rússia

Vladimir Panov

FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor; Institute of Industrial Ecology, the Urals Branch of the Russian Academy of Sciences

Email: vpanov@ecko.uran.ru
ORCID ID: 0000-0001-6718-3217

Кандидат физико-математических наук, старший научный сотрудник лаборатории математического моделирования в экологии и медицине Института промышленной экологии УрО РАН, г. Екатеринбург, Российская Федерация.

e-mail: vpanov@ecko.uran.ru

Rússia

Marina Sutunkova

FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor

Email: sutunkova@ymrc.ru
ORCID ID: 0000-0002-1743-7642

Доктор медицинских наук, директор ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора, г. Екатеринбург, Российская Федерация.

e-mail: sutunkova@ymrc.ru

Rússia

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Declaração de direitos autorais © Katsnelson B.A., Chernyshov I.N., Solovyeva S.N., Minigalieva I.A., Gurvich V.B., Valamina I.E., Makeyev O.H., Sahautdinova R.R., Privalova L.I., Tsaregorodtseva A.E., Korotkov A.V., Shuman E.A., Panov V.G., Sutunkova M.P., 2021



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