About the threshold concentration of nickel oxide nanoparticles in long-term inhalation exposure of rats
- Autores: Katsnelson B.A.1, Chernyshov I.N.1, Solovyeva S.N.1, Minigalieva I.A.1, Gurvich V.B.1, Valamina I.E.2, Makeyev O.H.2, Sahautdinova R.R.1, Privalova L.I.1, Tsaregorodtseva A.E.2, Korotkov A.V.2, Shuman E.A.2, Panov V.G.1,3, Sutunkova M.P.1
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Afiliações:
- FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor
- The Ural State Medical University
- Institute of Industrial Ecology, the Urals Branch of the Russian Academy of Sciences
- Edição: Nº 5 (2021)
- Páginas: 34-42
- Seção: Original articles
- ##submission.datePublished##: 14.10.2021
- URL: https://rjsvd.com/0869-7922/article/view/641377
- DOI: https://doi.org/10.36946/0869-7922-2021-29-5-34-42
- ID: 641377
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Texto integral
Resumo
Introduction. Nickel oxide nanoparticles are of interest for toxicological science, not only as engineered nanoparticles, producing for industrial and scientific needs, but also as spontaneous pollutants of the atmosphere and the working area in industrial processes related to metallurgy and welding.
Materials and methods. Rats were exposed to nickel-oxide aerosol at a concentration of 2.4 ± 0.4 µg/m3 in a “nose only” inhalation setup for 4 hours at a time, 5 times a week, during an overall period of 2 weeks to 6 months.
Results. Of the several dozen examined parameters, only a few statistically significant manifestations associated with the reaction of the deep airways to inhaled nanoparticles were noted. However, in the biochemical and morphometric parameters of the lungs, even at the longest periods of exposure, the intergroup differences were insignificant. At the same time, even from the first weeks of the exposure period, genotoxic and allergic indices shifts are detected.
Conclusion. For most of the evaluated effects, this level of exposure to nickel oxide nanoparticles may be considered as close to LOAEL, or even to NOAEL. However, according to some indicators, there are effects that suggest a non-threshold nature.
Sobre autores
Boris Katsnelson
FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor
Autor responsável pela correspondência
Email: bkaznelson@ymrc.ru
ORCID ID: 0000-0001-8750-9624
MD, professor, scientific consultant FBRI YMRC PHPIW of Rospotrebnadzor, 620014, Yekaterinburg, Russia.
e-mail: bkaznelson@ymrc.ru
RússiaIvan Chernyshov
FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor
Email: chernishov@ymrc.ru
ORCID ID: 0000-0002-2018-5386
Младший научный сотрудник отдела токсикологии и биопрофилактики ФБУН ЕМНЦ ПОЗРПП
Роспотребнадзора, г. Екатеринбург, Российская Федерация.
e-mail: chernishov@ymrc.ru
RússiaSvetlana Solovyeva
FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor
Email: solovyevasn@ymrc.ru
ORCID ID: 0000-0001-8580-403X
Заведующая клиникой экспериментальных животных ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора, г. Екатеринбург, Российская Федерация.
e-mail: solovyevasn@ymrc.ru
RússiaIlzira Minigalieva
FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor
Email: ilzira-minigalieva@yandex.ru
ORCID ID: 0000-0002-0097-7845
Доктор биологических наук, заведующий отделом токсикологии и биопрофилкатики, заведующий лабораторией промышленной токсикологии ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора, г. Екатеринбург, Российская Федерация.
e-mail: ilzira-minigalieva@yandex.ru
RússiaVladimir Gurvich
FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor
Email: gurvich@ymrc.ru
ORCID ID: 0000-0002-6475-7753
Доктор медицинских наук, профессор, научный руководитель ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора, г. Екатеринбург, Российская Федерация.
e-mail: gurvich@ymrc.ru
RússiaIrene Valamina
The Ural State Medical University
Email: ivalamina@mail.ru
ORCID ID: 0000-0001-7387-5287
Кандидат медицинских наук, старший научный сотрудник, заведующая лабораторией ЦНИЛ ГБОУ ВПО УГМУ, г. Екатеринбург, Российская Федерация.
e-mail: ivalamina@mail.ru
RússiaOleg Makeyev
The Ural State Medical University
Email: oomt305@maii.ru
ORCID ID: 0000-0001-6819-3185
Доктор медицинских наук, профессор, заведующий лабораторией технологий клеточной и генной терапии Института медицинских клеточных технологий, ГБОУ ВПО УГМУ, г. Екатеринбург, Российская Федерация.
e-mail: oomt305@maii.ru
RússiaRenata Sahautdinova
FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor
Email: sahautdinova@ymrc.ru
ORCID ID: 0000-0002-2726-9259
Кандидат медицинских наук, заведующий диагностическим лабораторным отделением НПО «Диагностических лабораторных технологий» ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора, г. Екатеринбург, Российская Федерация.
e-mail: sahautdinova@ymrc.ru
RússiaLarisa Privalova
FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor
Email: privalovali@yahoo.com
ORCID ID: 0000-0002-1442-6737
Доктор медицинских наук, профессор, заведующий лабораторией научных основ биопрофилактики ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора, г. Екатеринбург, Российская Федерация.
e-mail: privalovali@yahoo.com
RússiaAnastasia Tsaregorodtseva
The Ural State Medical University
Email: aisha12_95@mail.ru
ORCID ID: 0000-0001-9444-8399
Младший научный сотрудник лаборатории ЦНИЛ ГБОУ ВПО УГМУ, г. Екатеринбург, Российская Федерация.
e-mail: aisha12_95@mail.ru
RússiaArtem Korotkov
The Ural State Medical University
Email: oomt305@maii.ru
ORCID ID: 0000-0001-5114-6104
Кандидат медицинских наук, ведущий научный сотрудник лаборатории технологий клеточной и генной терапии Института медицинских клеточных технологий, ГБОУ ВПО УГМУ, г. Екатеринбург, Российская Федерация.
e-mail: oomt305@maii.ru
RússiaEvgeny Shuman
The Ural State Medical University
Email: oomt305@maii.ru
ORCID ID: 0000-0003-1981-4330
Мадший научный сотрудник лаборатории технологий клеточной и генной терапии Института медицинских клеточных технологий, ГБОУ ВПО УГМУ, г. Екатеринбург, Российская Федерация.
e-mail: oomt305@maii.ru
RússiaVladimir Panov
FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor; Institute of Industrial Ecology, the Urals Branch of the Russian Academy of Sciences
Email: vpanov@ecko.uran.ru
ORCID ID: 0000-0001-6718-3217
Кандидат физико-математических наук, старший научный сотрудник лаборатории математического моделирования в экологии и медицине Института промышленной экологии УрО РАН, г. Екатеринбург, Российская Федерация.
e-mail: vpanov@ecko.uran.ru
RússiaMarina Sutunkova
FBRI “The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers” of Rospotrebnadzor
Email: sutunkova@ymrc.ru
ORCID ID: 0000-0002-1743-7642
Доктор медицинских наук, директор ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора, г. Екатеринбург, Российская Федерация.
e-mail: sutunkova@ymrc.ru
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