CHEMICAL SAFETY AS TOXICOLOGICAL AND EPIDEMIOLOGICAL ISSUE IN MEDICAL SCIENCE AND PRACTICE

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Abstract

The paper deals with factors of the current chemical burden of human population, including food and epidemiological disinfectants, and their potential toxicological impact. Methods of chemical exposure assessment in animal experiments are discussed on the basis of establishing thresholds of its severity. It was suggested that at the sub-threshold exposure, temporarily hidden health effects can also occur, which may only manifest in the form of relevant pathologies at population level. Not only individual but also collective (population) toxic exposure doses should be taken into account when evaluating chemical burden of human population; therefore it is reasonable to develop medical population toxicology as a special area within the toxicology science based both on epidemiological principles in general and on prognosticated advances in epidemiology of non-communicable diseases, in particular.

About the authors

Viktor Aleksandrovich Tutelian

Federal State Budgetary Science Institution «Institute of Nutrition», Russian Academy of Sciences;State Budgetary Educational Institution of Higher Professional Education «I.M. Sechenov Moscow State Medical University»

Author for correspondence.
Email: noemail@neicon.ru

Доктор медицинских наук, профессор, академик РАН, директор ФГБУ «НИИ питания» РАН, профессор ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» МЗ РФ, 109240, г. Москва

e-mail: tutelyan@ion.ru

Russian Federation

Mikhail Georgiyevich Shandala

Federal Budgetary Science Institution «Institute of Discinfectology», Rospotrebnadzor;State Budgetary Educational Institution of Higher Professional Education «I.M. Sechenov Moscow State Medical University»

Email: noemail@neicon.ru

Доктор медицинских наук, профессор, академик РАН, главный научный сотрудник ФБУН «Научно-исследовательский институт дезинфектологии» Роспотребнадзора, профессор ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» МЗ РФ, 117246, г. Москва

e-mail: info@niid.ru

Russian Federation

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