Email this article STUDY OF THE EFFECTIVENESS OF RECOMBINANT PLASMIDS IN A NEUROPATHY MODEL AT POISONING WITH MALATHION
- Authors: Shilov V.V.1, Judin M.A.2, Shherbakov T.V.1, Belichenko O.A.1
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Affiliations:
- Northwest Scientific Center of Hygiene and Public Health
- Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy
- Issue: No 4 (2015)
- Pages: 26-30
- Section: Articles
- Published: 30.08.2015
- URL: https://rjsvd.com/0869-7922/article/view/641342
- DOI: https://doi.org/10.15690/vramn499
- ID: 641342
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Abstract
The effectiveness of gene therapy agents application, i.e.: recombinant plasmid DNA (RPD) coding body growth factor production (nerve growth factor (NGF), vascular endothelial growth factor (VEGF) and somatoliberin-1) was shown using a model of peripheral neuropathy caused by a thrice-repeated 0.5 LD50 malathion injection to rats. RPD NGF and RPD VEGF were found to have the strongest nerve tissue protective effect. According to electrophysiological studies findings, the preparations based on these plasmid constructions exerted a positive effect as early as a week after the damage and completely removed neuropathy manifestations by the 21 day.
About the authors
Viktor Vasil’evich Shilov
Northwest Scientific Center of Hygiene and Public Health
Author for correspondence.
Email: noemail@neicon.ru
Доктор медицинских наук, профессор, директор ФБУН «Северо-Западный научный центр гигиены и общественного здоровья» Роспотребнадзора, 191036, г. Санкт-Петербург, Российская Федерация
e-mail: vshilov@inbox.ru
Russian FederationMikhail Anatol’evich Judin
Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy
Email: noemail@neicon.ru
Доцент кандидат медицинских наук заместитель начальника отдела Научно-исследовательского испытательного института военной медицины Военно-медицинской академии имени С.М. Кирова, 195043, г. Санкт-Петербург, Российская Федерация,
e-mail: mikhail.judin@gmail.com
Russian FederationTaras Vladimirovich Shherbakov
Northwest Scientific Center of Hygiene and Public Health
Email: noemail@neicon.ru
Аспирант ФБУН «Северо-Западный научный центр гигиены и общественного здоровья» Роспотребнадзора, 191036, г. Санкт-Петербург, Российская Федерация
e-mail: taraskbr@yandex.ru
Russian FederationOlga Alexandrovna Belichenko
Northwest Scientific Center of Hygiene and Public Health
Email: noemail@neicon.ru
Лаборант-исследователь лаборатории токсикологии ФБУН «Северо-Западный научный центр гигиены и общественного здоровья» Роспотребнадзора, 191036, г. Санкт-Петербург, Российская Федерация
e-mail: sznc.viv@gmail.com
Russian FederationReferences
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