STRATEGY AND TACTICS OF TNE PESTICIDE MUTAGENECITY ASSESSMENT

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Abstract

Toxicological and hygienic risk assessment of pesticides widespread use to human health includes the analysis of their mutagenic activity as a compulsory part. A risk assessment strategy of pesticides mutagenic impacts based on their hygiene classification by mutagenicity criterion is presented. Changes in tactical approaches having occurred recently are considered. A set of methods harmonized with international requirements for assessment of mutagenic activity of pesticides, main metabolites and components of their preparative forms is recommended. It allows to determine a hazard class by a given harmful index. Issues are considered in respect to the usage of short-time testing for assessment of generic pesticides mutagenicity, determination of preparative forms potential genotoxicity and forecasting carcinogenic properties of substances under consideration.

About the authors

Valery Nikolaevich Rakitskii

The Federal Budgetary Science Institution «F.F. Erisman Federal Scientific Centre of Hygiene», Federal Service for Surveillance on Consumer Rights and Human Well-being (Rospotrebnadzor)

Author for correspondence.
Email: noemail@neicon.ru

Академик РАН, профессор, и.о. директора ФБУН «Федеральный научный центр гигиены им.Ф.Ф.Эрисмана» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека, 141014, Московская область, г. Мытищи, Российская Федерация

e-mail: pesticide@yandex.ru

Russian Federation

Yulia Anatolevna Revazova

The Federal Budgetary Science Institution «F.F. Erisman Federal Scientific Centre of Hygiene», Federal Service for Surveillance on Consumer Rights and Human Well-being (Rospotrebnadzor)

Email: noemail@neicon.ru

Доктор биологических наук, профессор, заслуженный деятель науки РФ, ведущий научный сотрудник отдела генетической токсикологии ФБУН Федерального бюджетное учреждение науки «Федеральный научный центр гигиены им.Ф.Ф.Эрисмана» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека, 141014, Московская область, г. Мытищи, Российская Федерация

e-mail: Revazova013@gmail.com

Russian Federation

Natalia Alexeevna Ilyushina

The Federal Budgetary Science Institution «F.F. Erisman Federal Scientific Centre of Hygiene», Federal Service for Surveillance on Consumer Rights and Human Well-being (Rospotrebnadzor)

Email: noemail@neicon.ru

 Кандидат биологических наук, заведующий отделом генетической токсикологии ФБУН «Федеральный научный центр гигиены им.Ф.Ф.Эрисмана» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека, 141014, Московская область, г. Мытищи, Российская Федерация

e-mail: Ilyushina-na@mail.ru

Russian Federation

References

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Copyright (c) 2015 Rakitskii V.N., Revazova Y.A., Ilyushina N.A.


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