Email this article EVALUATION OF CYTOTOXICITY AND GENOTOXICITY OF NEW SUBSTITUTED PIRYDO [1,2-A] BENZIMIDAZOLES USING THE ALLIUM TEST
- Authors: Begunov R.S.1, Sokolov A.A.1, Shebunina T.V.1, Kalina S.A.1, Bashkirova A.A.1
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Affiliations:
- Federal State Budgetary Educational Institution of Additional Higher Education «P.G. Demidov Yaroslavl State University»
- Issue: No 2 (2015)
- Pages: 35-39
- Section: Articles
- Published: 06.04.2015
- URL: https://rjsvd.com/0869-7922/article/view/641316
- DOI: https://doi.org/10.15690/vramn447
- ID: 641316
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Abstract
Investigations were carried out into mutagenic and mitosis modifying action (Allium test) of imidazole new polycyclic condensed derivatives having a high ability to embed into DNA molecules: 7-trifluor methyl pyrido [1,2- a] benzimidazole, 7- nitropyrido[1,2-a] benzimidazole, 7- amino pyrido [1,2- a] benzimidazole, 8-nitro- 7-trifluor methyl pyrido[1,2-a]benzimidazole, 8-amino- 7-trifluor methyl pyrido[1,2-a] benzimidazole. The evaluation of cytotoxic effect of compounds under investigation was performed by comparing with toxicological characteristics of a widely used DNA –intercalator 9-amino acridine. All azagetero cycles induced reduction of the prophase index evidencing their impact on the process of DNA replication. The most wide spread mutations were “bridge” type pathologies as a result of reunion of different daughter cells chromosomes and obliteration and losses of entire chromosomes at cells division. All mono- and di-substituted pirido[1,2-a] benzimidazoles produced a lesser mitodepressive and mutagenic action than 9-amino acridine. Monosubstituted pirido[1,2-a]benzimidazoles had lesser cytotoxicity and mutagenicity in the A cepa test-system.
About the authors
Roman Sergeevich Begunov
Federal State Budgetary Educational Institution of Additional Higher Education «P.G. Demidov Yaroslavl State University»
Author for correspondence.
Email: noemail@neicon.ru
Кандидат химических наук, доцент, кафедра органической и биологической химии факультета биологии и экологии ФГБОУ ВПО «Ярославский государственный университет им. П.Г. Демидова», г. Ярославль
e-mail: begunov@bio.uniyar.ac.ru
Russian FederationAlexander Andreevich Sokolov
Federal State Budgetary Educational Institution of Additional Higher Education «P.G. Demidov Yaroslavl State University»
Email: noemail@neicon.ru
Аспирант второго года обучения, специальности 02.00.03, факультет биологии и экологии ФГБОУ ВПО «Ярославский государственный университет им. П.Г. Демидова», г. Ярославль
e-mail: morose@mail.ru
Russian FederationTatyana Viktorovna Shebunina
Federal State Budgetary Educational Institution of Additional Higher Education «P.G. Demidov Yaroslavl State University»
Email: noemail@neicon.ru
Магистрант первого года обучения, специальность Химия, факультет биологии и экологии ФГБОУ ВПО «Ярославский государственный университет им. П.Г. Демидова», г. Ярославль
e-mail: tan4ik2107@mail.ru
Russian FederationSvetlana Alexandrovna Kalina
Federal State Budgetary Educational Institution of Additional Higher Education «P.G. Demidov Yaroslavl State University»
Email: noemail@neicon.ru
Студентка 3 курса, специальность Химия, факультет биологии и экологии ФГБОУ ВПО «Ярославский государственный университет им. П.Г. Демидова», г. Ярославль
e-mail: svetlana_kalina1993@mail.ru
Russian FederationAlexandra Alexandrovna Bashkirova
Federal State Budgetary Educational Institution of Additional Higher Education «P.G. Demidov Yaroslavl State University»
Email: noemail@neicon.ru
Студентка 3 курса, специальность Химия, факультет биологии и экологии ФГБОУ ВПО «Ярославский государственный университет им. П.Г. Демидова», г. Ярославль
e-mail: yarchemlab@gmail.com
Russian FederationReferences
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